Fluorescent/PET bimodal image probe and preparation method and application thereof
A dual-modality, imaging technology, applied in the field of biomedicine, can solve problems such as poor diagnosis of suspicious lesions
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[0076] As a preferred embodiment of the present invention, hollow mesoporous organosilicon supports fluorescein FITC and nuclide 64 Cu, can be abbreviated as HMON-FITC / 64 Cu.
[0077] HMON-FITC / 64 The " / " in Cu means "and", which means that the HMON is loaded with FITC and 64 Cu.
[0078] Fluorescein FITC can be used for fluorescence imaging, while nuclides 64 Cu can be used for PET imaging, fluorescein FITC and radionuclides 64 Cu is simultaneously loaded on HMON, which enables the probe to have both fluorescence imaging and PET imaging modalities.
[0079] It should be noted that fluorescein FITC and nuclide 64 Cu can be loaded on the surface and / or in the pores of HMON.
[0080] As an optional embodiment of the present invention, fluorescein FITC and radionuclide 64 Cu is grafted on hollow mesoporous silicone.
[0081] As an optional embodiment of the present invention, HMON is a hollow mesoporous organosilicon containing disulfide bonds.
[0082] The disulfide-...
Embodiment 1
[0143] This example provides a fluorescence / PET dual-modal imaging probe, which uses degradable hollow mesoporous silicone as a carrier, and the hollow mesoporous silicone supports fluorescein FITC and nuclide 64 Cu.
[0144] The preparation method of the fluorescence / PET dual-modality image probe in this embodiment includes the following steps:
[0145] (a) use The preparation of solid silica SN by the method includes the following steps: in a mixed solution consisting of 74 mL of ethanol, 10 mL of ultrapure water and 3.14 mL of ammonia water, 6 mL of TEOS was rapidly added dropwise, and then stirred and reacted in a water bath at 30 °C for 1 h, and the product was collected by centrifugation. And washed with ethanol three times to obtain solid silica SN, and the solid silica SN was dispersed in 60 mL of ultrapure water to obtain an aqueous silica solution;
[0146] The preparation of mesoporous silicone-coated solid silica SN@MON includes the following steps: dissolve 2 g...
Embodiment 2
[0153] This embodiment provides a fluorescence / PET dual-modality imaging probe, except that the aminosilane coupling agent used in step (a) of the preparation method of the fluorescence / PET dual-modality imaging probe is replaced by APTES with (3- aminopropyl) trimethoxysilane APTMS, and other preparation steps are the same as those in Example 1.
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