Fluorescent/PET bimodal image probe and preparation method and application thereof

A dual-modality, imaging technology, applied in the field of biomedicine, can solve problems such as poor diagnosis of suspicious lesions

Pending Publication Date: 2021-09-14
NANJING NUOYUAN MEDICAL DEVICES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The first purpose of the present invention is to provide a fluorescence / PET dual-mode imaging probe to alleviate the technical problems in the prior art, such as the poor diagnostic effect of using a single imaging mode to find suspicious lesions

Method used

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  • Fluorescent/PET bimodal image probe and preparation method and application thereof
  • Fluorescent/PET bimodal image probe and preparation method and application thereof
  • Fluorescent/PET bimodal image probe and preparation method and application thereof

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Embodiment approach

[0076] As a preferred embodiment of the present invention, hollow mesoporous organosilicon supports fluorescein FITC and nuclide 64 Cu, can be abbreviated as HMON-FITC / 64 Cu.

[0077] HMON-FITC / 64 The " / " in Cu means "and", which means that the HMON is loaded with FITC and 64 Cu.

[0078] Fluorescein FITC can be used for fluorescence imaging, while nuclides 64 Cu can be used for PET imaging, fluorescein FITC and radionuclides 64 Cu is simultaneously loaded on HMON, which enables the probe to have both fluorescence imaging and PET imaging modalities.

[0079] It should be noted that fluorescein FITC and nuclide 64 Cu can be loaded on the surface and / or in the pores of HMON.

[0080] As an optional embodiment of the present invention, fluorescein FITC and radionuclide 64 Cu is grafted on hollow mesoporous silicone.

[0081] As an optional embodiment of the present invention, HMON is a hollow mesoporous organosilicon containing disulfide bonds.

[0082] The disulfide-...

Embodiment 1

[0143] This example provides a fluorescence / PET dual-modal imaging probe, which uses degradable hollow mesoporous silicone as a carrier, and the hollow mesoporous silicone supports fluorescein FITC and nuclide 64 Cu.

[0144] The preparation method of the fluorescence / PET dual-modality image probe in this embodiment includes the following steps:

[0145] (a) use The preparation of solid silica SN by the method includes the following steps: in a mixed solution consisting of 74 mL of ethanol, 10 mL of ultrapure water and 3.14 mL of ammonia water, 6 mL of TEOS was rapidly added dropwise, and then stirred and reacted in a water bath at 30 °C for 1 h, and the product was collected by centrifugation. And washed with ethanol three times to obtain solid silica SN, and the solid silica SN was dispersed in 60 mL of ultrapure water to obtain an aqueous silica solution;

[0146] The preparation of mesoporous silicone-coated solid silica SN@MON includes the following steps: dissolve 2 g...

Embodiment 2

[0153] This embodiment provides a fluorescence / PET dual-modality imaging probe, except that the aminosilane coupling agent used in step (a) of the preparation method of the fluorescence / PET dual-modality imaging probe is replaced by APTES with (3- aminopropyl) trimethoxysilane APTMS, and other preparation steps are the same as those in Example 1.

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Abstract

The invention provides a fluorescent/PET bimodal image probe and a preparation method and application thereof, and relates to the technical field of biomedicine. According to the fluorescent/PET bimodal image probe, fluorescein and nuclide are loaded on hollow mesoporous organic silicon at the same time, so that the probe has two imaging modes of fluorescent imaging and PET imaging, by integrating the advantages of the different imaging modes, the distribution of the positioning probe can be observed at the cell level and the living body level at the same time, early accurate diagnosis of tumors is also facilitated, and efficient treatment can be implemented as soon as possible. The invention further provides the preparation method of the fluorescent/PET bimodal image probe, the process is simple and easy to implement, the cost is low, the efficiency is high, and the fluorescent/PET bimodal image probe has important research significance and wide application prospects in the field of biomedical imaging. The invention also provides an application of the fluorescence/PET bimodal image probe in preparation of a tumor accurate diagnosis preparation or a tumor treatment preparation.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a fluorescence / PET dual-mode image probe and a preparation method and application thereof. Background technique [0002] Cancer has become a major killer of human health. The first step in effectively curing cancer is to use precise imaging technology to locate the tumor's location before treatment can be administered. Imaging techniques for early diagnosis of cancer include magnetic resonance (MRI), fluorescence, PET, and CT scans. Unfortunately, most of the current clinical practice is to use a single imaging mode to find suspicious lesions, which undoubtedly has many defects, resulting in poor diagnosis. [0003] In view of this, the present invention is proposed to solve at least one of the above technical problems. SUMMARY OF THE INVENTION [0004] The first objective of the present invention is to provide a fluorescence / PET dual-modality imaging probe, so as to all...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00A61K51/04A61K45/00A61K47/24A61P35/00A61K103/00A61K103/32
CPCA61K49/0043A61K49/0052A61K51/04A61K45/00A61K47/24A61P35/00
Inventor 蔡惠明倪轲娜卢露
Owner NANJING NUOYUAN MEDICAL DEVICES CO LTD
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