<125>I drug marking and purifying device and method thereof

Abstract

The invention discloses a <125> I drug marking and purifying device and method. The marking and purifying device comprises a pressure device, a to-be-marked medicine solution raw material bottle, a <125>I solution raw material bottle, a chloramine T solution raw material bottle, a sodium metabisulfite solution raw material bottle, a PBS solution raw material bottle, a reaction bottle, a purifying column, an automatic collecting device, a three-way valve and a one-way valve. The <125>I drug marking and purifying device provided by the invention is simple to operate, safe and convenient, and effectively reduces the ionizing radiation exposure of operators; the marking and purifying processes are carried out in the device, so that isotope pollution is not easy to occur; the marking and purification of the <125>I drug can be efficiently, quickly and accurately completed; and the marking and purifying method provided by the invention is easy to operate, marking can be efficiently and quickly completed, and the radiochemical purity of the marked drug can reach 90% or above.

Description

technical field [0001] The present invention relates to a 125 1 Drug labeling and purification device and method thereof. Background technique [0002] 125 The half-life of I particles is 59.6 days, the emitted gamma-ray energy is 27-35keV, the half-value thickness to lead is 0.025mm, and the effective radiation radius in the tissue is about 17-20mm. Therefore, 125 I-labeled drugs can act on local tumors for a long time, and continuous irradiation can more completely destroy DNA double-strand breaks, which can significantly increase the killing effect of tumor cells. [0003] Currently, in the synthesis of radiopharmaceuticals, manual methods are mainly used. In the actual operation process, it will bring greater risks to the staff and is prone to isotope contamination. Therefore, urgently need to provide a kind of marking personnel and 125 I source contact time is short, avoid ionizing radiation due to long-term contact, high safety factor 125 I drug labeling and puri...

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved in the present invention is in order to overcome in prior art 125 When labeling and purifying drugs, the manual method is mainly used, which will bring greater risks to the staff, has a low safety factor, and is prone to defects of isotope contamination, providing a 125 I The drug labeling and purification device and its method are simple, safe and convenient to operate, effectively reduce the ionizing radiation exposure of operators, and can be completed efficiently, quickly and accurately 125 I drug labeling and purification

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