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Glioma sorting device for collecting tumor nucleic acid based on mononuclear cells

A technology for mononuclear cells, gliomas, applied in the field of medical devices

Pending Publication Date: 2021-09-14
NANJING MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to provide a glioma sorting device based on mononuclear cells to collect tumor nucleic acid, aiming to solve various shortcomings in the existing early detection and postoperative monitoring methods of glioma-specific markers

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  • Glioma sorting device for collecting tumor nucleic acid based on mononuclear cells
  • Glioma sorting device for collecting tumor nucleic acid based on mononuclear cells
  • Glioma sorting device for collecting tumor nucleic acid based on mononuclear cells

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Embodiment Construction

[0028] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0029] The invention discloses a glioma sorting device for collecting tumor nucleic acid based on monocytes, such as figure 1 As shown, the device includes:

[0030] Collection module 1, used to collect tumor nucleic acid in monocytes for sequencing

[0031] Draw 10ml of peripheral blood, store in EDTA anticoagulant tube, store at 4°C or insert crushed ice for transportation; dilute whole blood with 10ml DPBS, add layering solution first and then The order of adding the diluted blood is to make the layered liquid at the bottom, and the diluted blood is stacked on the layered liquid; use a horizon...

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Abstract

The invention discloses a glioma sorting device for collecting tumor nucleic acid based on mononuclear cells; the device comprises a collection module which is used for collecting the tumor nucleic acid in the mononuclear cells; an information comparison module, which is used for processing off-computer data of high-throughput sequencing and comparing the off-computer data to a reference genome to obtain expression information; an information analysis module, which is used for counting expression of genes in the gene combination and calculating a glioma characteristic gene score; a judgment module, which is used for predicting the glioma state of the to-be-detected sample according to the calculated glioma characteristic gene score. The device can be used for early diagnosis and analysis of tumors, early discovery and early treatment are achieved, the treatment effectiveness is improved, and the situation that treatment is invalid after the tumors are advanced is avoided.

Description

technical field [0001] The invention belongs to the field of medical devices, in particular to a glioma sorting device for collecting tumor nucleic acid based on monocytes. Background technique [0002] Existing sorting devices include various imaging examinations, mainly including magnetic resonance imaging (magneticresonance imaging, MRI), X-ray computerized tomography (Computed Tomography, CT), single-photon emission computed tomography (Single-Photon Emission Computed Tomography, SPECT) and Positron Emission Tomography-Computed Tomography (PET-CT), etc. The disadvantage of conventional imaging methods is that it is difficult to find tiny lesions with a diameter of less than 1 cm. In addition, molecular imaging technology can detect tumor cell signals in a non-invasive early stage by using tumor molecular marker probes and imaging methods such as MRI. However, the design of specific molecular probes is relatively complicated (for example, it is necessary to design metab...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B30/10G16B35/20G16B40/00G16B50/00
CPCG16B30/10G16B35/20G16B40/00G16B50/00C12Q1/6886C12Q1/6869C12Q1/6806C12Q2535/122C12Q2563/143C12Q2563/149C12Q2563/131C12Q2525/191Y02A90/10
Inventor 汪强虎吴维吴玲祥王子宇
Owner NANJING MEDICAL UNIV
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