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Symmetrical bow-shaped flexible metasurface sensor for biological cancer cell detection and application

A cancer cell and metasurface technology, applied in the direction of instruments, measuring devices, scientific instruments, etc., can solve the problems of single sensing performance and parameters, and achieve the effect of increasing the abundance of sensing and the convenience and safety of parameters and inspection methods

Pending Publication Date: 2021-09-21
NORTH CHINA UNIV OF WATER RESOURCES & ELECTRIC POWER
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Problems solved by technology

[0004] The purpose of the present invention is to propose a symmetrical bow-shaped flexible metasurface sensor for the detection of biological cancer cells, which can effectively solve the problem of single sensing performance and parameters of the current metasurface biosensor, and realize multi-performance detection of concentration and type at the same time

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  • Symmetrical bow-shaped flexible metasurface sensor for biological cancer cell detection and application
  • Symmetrical bow-shaped flexible metasurface sensor for biological cancer cell detection and application
  • Symmetrical bow-shaped flexible metasurface sensor for biological cancer cell detection and application

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Embodiment Construction

[0022] In order to make the object, technical solution and test of the present invention more clear, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific examples described here are only used to explain the present invention, not to limit the present invention.

[0023] A metasurface is a two-dimensional artificial electromagnetic material composed of periodic arrangements of unit structures, which can greatly enhance the local field strength at the subwavelength scale and effectively improve the detection ability of trace analytes, only by designing a resonant structure. Flexible control of its electromagnetic properties. The present invention designs a symmetrical bow-shaped flexible metasurface as a biosensing platform, and uses THz incident waves to detect cancer cells. When the external boundary conditions of the metasurface change, the external matter attached to the metasurface absor...

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Abstract

The invention discloses a symmetrical bow-shaped flexible metasurface sensor for biological cancer cell detection and application, the sensor comprises a substrate, symmetrical metal bow-shaped rings are etched on the substrate, and the substrate and the surface symmetrical metal bow-shaped rings form the metasurface sensor. Terahertz time-domain spectroscopy is used for testing a time-domain signal of the metasurface sensor, inner product operation is carried out on a Moire wavelet function and the time-domain signal obtained through testing through matlab programming, the Moire wavelet function is transversely translated to obtain time-domain information, the Moire wavelet function is longitudinally stretched to obtain frequency-domain information, and wavelet coefficients are extracted to obtain extinction spectrum intensity. And two-dimensional visual output of different concentrations and different biological samples which change in the time domain and the frequency domain at the same time is achieved by using a wavelet coefficient obtained by the inner product of the Moire wavelet function and the time domain signal. According to the invention, two-dimensional visual output of different biological samples with different concentrations is realized at the same time, multi-performance detection of the metasurface sensor is realized, and the limitation that the resolution of a flow cytometer is zero is broken through.

Description

technical field [0001] The invention relates to the application of metasurfaces in the field of biosensing, in particular to sensors based on symmetrical bow-shaped flexible metasurfaces. Background technique [0002] Terahertz (THz) waves refer to electromagnetic waves with a frequency in the range of 0.1-10 THz (wavelength 0.03mm-3mm), which overlaps with millimeter waves (submillimeter waves) in the long wave band, and can just cover organisms and biological macromolecules, etc. The characteristic spectrum of a substance. Therefore, THz has great application value in biomedical detection. [0003] Traditional human fluoroscopy and radiography both use X-rays, but X-rays will cause side effects on the human body due to the ionization brought about when they penetrate. In addition, X-rays are very penetrating and cannot distinguish between normal cells and cancer cells. The penetration of ultrasound is slightly weaker, and it cannot irradiate the inside of cells, and can ...

Claims

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Application Information

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IPC IPC(8): G01N15/10G01N21/3581
CPCG01N15/10G01N21/3581G01N2015/1006G01N2015/1022
Inventor 邴丕彬王花国馨月陈治良张红涛许若辰赵江飞
Owner NORTH CHINA UNIV OF WATER RESOURCES & ELECTRIC POWER
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