Symmetrical bow-shaped flexible metasurface sensor for biological cancer cell detection and application

Abstract

The invention discloses a symmetrical bow-shaped flexible metasurface sensor for biological cancer cell detection and application, the sensor comprises a substrate, symmetrical metal bow-shaped rings are etched on the substrate, and the substrate and the surface symmetrical metal bow-shaped rings form the metasurface sensor. Terahertz time-domain spectroscopy is used for testing a time-domain signal of the metasurface sensor, inner product operation is carried out on a Moire wavelet function and the time-domain signal obtained through testing through matlab programming, the Moire wavelet function is transversely translated to obtain time-domain information, the Moire wavelet function is longitudinally stretched to obtain frequency-domain information, and wavelet coefficients are extracted to obtain extinction spectrum intensity. And two-dimensional visual output of different concentrations and different biological samples which change in the time domain and the frequency domain at the same time is achieved by using a wavelet coefficient obtained by the inner product of the Moire wavelet function and the time domain signal. According to the invention, two-dimensional visual output of different biological samples with different concentrations is realized at the same time, multi-performance detection of the metasurface sensor is realized, and the limitation that the resolution of a flow cytometer is zero is broken through.

Description

technical field [0001] The invention relates to the application of metasurfaces in the field of biosensing, in particular to sensors based on symmetrical bow-shaped flexible metasurfaces. Background technique [0002] Terahertz (THz) waves refer to electromagnetic waves with a frequency in the range of 0.1-10 THz (wavelength 0.03mm-3mm), which overlaps with millimeter waves (submillimeter waves) in the long wave band, and can just cover organisms and biological macromolecules, etc. The characteristic spectrum of a substance. Therefore, THz has great application value in biomedical detection. [0003] Traditional human fluoroscopy and radiography both use X-rays, but X-rays will cause side effects on the human body due to the ionization brought about when they penetrate. In addition, X-rays are very penetrating and cannot distinguish between normal cells and cancer cells. The penetration of ultrasound is slightly weaker, and it cannot irradiate the inside of cells, and can ...

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to propose a symmetrical bow-shaped flexible metasurface sensor for the detection of biological cancer cells, which can effectively solve the problem of single sensing performance and parameters of the current metasurface biosensor, and realize multi-performance detection of concentration and type at the same time

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