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Multichannel open-tube silica gel capillary column using a metal filament as template and a preparation method thereof

A capillary column and metal filament technology, applied in the field of chromatographic columns, can solve problems such as complex preparation methods, and achieve the effects of simple preparation methods, controllable channel morphology, and high column efficiency

Active Publication Date: 2021-09-21
ANHUI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the existing preparation methods are relatively complicated

Method used

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  • Multichannel open-tube silica gel capillary column using a metal filament as template and a preparation method thereof
  • Multichannel open-tube silica gel capillary column using a metal filament as template and a preparation method thereof
  • Multichannel open-tube silica gel capillary column using a metal filament as template and a preparation method thereof

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Experimental program
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Effect test

preparation example Construction

[0035] The first aspect of the present invention provides a method for preparing a multi-channel open-tube silica gel capillary column with metal filaments as a template, comprising the following steps: (1) performing primary polymerization through the sol solution in contact with the metal filaments, to A polymerized stationary phase layer is formed on the surface of the wire to obtain a metal wire with a stationary phase layer; (2) the metal wire with a stationary phase layer is introduced into the capillary, and secondary polymerization is initiated in the sol solution, and then aged by heating, Obtain a capillary column containing a silica gel stationary phase; (3) remove the metal wire in the capillary column by an in-situ dissolution method, and then obtain a multi-channel open-tube silica gel capillary column by calcining; wherein, in step (1), step (2) The sol solutions each contained polyethylene glycol, urea, methyl orthosilicate and acetic acid solutions.

[0036]Th...

Embodiment 1

[0073] like figure 1 In the model, multiple copper wire templates are introduced into the capillary by a single metal wire pulling multiple metal wires. In a, a single metal wire is first introduced into the empty capillary, and in b and c, multiple metal wires are introduced into the capillary. Filament schematic. Preferably, the single metal filament is a 25 μm nickel-chromium wire.

Embodiment 2

[0075] like figure 2 As shown, a single metal wire is used to pull multiple metal wires, and 10-14 copper filaments are introduced into a 100 μm capillary. die according to figure 2 introduced into the capillary as shown.

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Abstract

The invention discloses a multichannel open-tube silica gel capillary column using a metal filament as a template and a preparation method thereof, and the preparation method comprises the following steps: (1) carrying out primary polymerization under the contact of a sol solution and a metal wire to form a polymerized stationary phase layer on the surface of the metal wire to obtain the metal wire with the stationary phase layer; (2) introducing the metal wire with the stationary phase layer into a capillary tube, initiating secondary polymerization in a sol solution, and heating and aging to obtain a capillary column containing a silica gel stationary phase; and (3) removing the metal wires in the capillary column by an in-situ dissolution method, and calcining to obtain a multichannel open-tube silica gel capillary column, wherein the sol solution in the step (1) and the sol solution in the step (2) respectively contain polyethylene glycol, urea, tetramethyl orthosilicate and an acetic acid solution. The silica gel capillary column has the characteristics of low column pressure, high column capacity and high column efficiency.

Description

technical field [0001] The invention relates to a chromatographic column, in particular to a multi-channel open-tube silica gel capillary column using metal filaments as a template and a preparation method thereof. Background technique [0002] Liquid chromatographic analysis occupies an important position in chromatographic analytical chemistry, and it has become an important detection technology in environmental analysis, life analytical chemistry, and scientific pharmaceutical analysis. Chromatography research is still focused on dealing with two most basic problems: one is to be controlled by the force difference between the separated components and the two phases of the chromatography to solve the problem of peak spacing, which is controlled by chromatographic thermodynamic factors; the other is to suppress various peak broadening factors Improve column efficiency to achieve separation of realistic kinetic problems. The former is the premise of separation, while the la...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06G01N30/86
CPCG01N30/02G01N30/06G01N30/8679G01N2030/062
Inventor 陆波朱昌青程东轩王亚娟李佩恒
Owner ANHUI NORMAL UNIV
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