Unlock instant, AI-driven research and patent intelligence for your innovation.

Perampanel tablet and preparation method therefor

A technology of perampanel tablets and polyethylene glycol, which is applied in the field of medicine, can solve the problems that patients cannot be effectively controlled, and achieve the effects of easy industrialized large-scale production, high stability, and simple preparation process

Pending Publication Date: 2021-09-28
BEIJING VENTUREPHARM BIOTECH
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Perampanel is a popular antiepileptic drug because many patients with partial seizures cannot be effectively controlled by other treatments; current first-line antiepileptic drugs work by inhibiting postsynaptic glutamate AMPA receptors function, and postsynaptic glutamate AMPA receptors are now thought to be involved in seizures

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Perampanel tablet and preparation method therefor
  • Perampanel tablet and preparation method therefor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Prescription for 1000 tablets:

[0027] Perampanel 50g

[0028] Polyethylene glycol 50g

[0029] Copovidone 350g

[0030] Microcrystalline Cellulose 350g

[0031] Crospovidone 25g

[0032] Magnesium Stearate 5g

[0033] Ethanol 1000g

[0034] Preparation process: (1) Heat perampanel and polyethylene glycol to melt at 80°C, add the molten liquid to the ethanol solution of copovidone in the prescribed amount, stir well and set aside

[0035] (2) crospovidone and microcrystalline cellulose are passed through 80 mesh sieves respectively, and set aside;

[0036] (3) Add the prescription amount of excipients in step (2) into step (1), stir evenly, dry below 50°C, add magnesium stearate, mix evenly, and press into tablets.

Embodiment 2

[0038] Prescription for 1000 tablets:

[0039] Perampanel 50g

[0040] Polyethylene glycol 50g

[0041] Copovidone 300g

[0042] Sorbitol 350g

[0043] Crospovidone 25g

[0044] Magnesium Stearate 5g

[0045] Ethanol 1000g

[0046] The preparation process is the same as in Example 1.

Embodiment 3

[0048] Prescription for 1000 tablets:

[0049] Perampanel 50g

[0050] Polyethylene glycol 50g

[0051] Copovidone 450g

[0052] Microcrystalline Cellulose 350g

[0053] Sodium carboxymethyl starch 25g

[0054] Magnesium Stearate 5g

[0055] Ethanol 1000g

[0056] The preparation process is the same as in Example 1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a perampanel tablet and a preparation method therefor. Prescription comprises perampanel, polyethylene glycol, copovidone, a filling agent, a disintegrating agent and a lubricating agent. According to the perampanel tablet and the method, the perampanel and the polyethylene glycol are firstly fused and then added into an ethanol solution of the copovidone, and then the corresponding filling agent, disintegrating agent and lubricating agent are added for tabletting; and the dissolution effect of the prepared perampanel tablet is remarkably improved, the dissolution amount can reach 80% or above within 10 min, the long-term storage is achieved, the stability is good, the preparation process is simple, complex equipment is not needed, and the industrial mass production is facilitated.

Description

technical field [0001] The invention relates to a perampanel tablet and a preparation method thereof. The preparation process of the method is simple and controllable, and the prepared tablet has high dissolution rate, quick onset and stable curative effect, and belongs to the technical field of medicine. Background technique [0002] Perampanel is an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist that reduces neuronal overexcited. Perampanel is a popular antiepileptic drug because many patients with partial seizures cannot be effectively controlled by other treatments; current first-line antiepileptic drugs work by inhibiting postsynaptic glutamate AMPA receptors play a role, while postsynaptic glutamate AMPA receptors are currently thought to be involved in seizures. Results of clinical trials showed that patients who took perampanel had better seizure control than those who took a placebo. This is the first antiepileptic drug with this ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/20A61K47/10A61K47/32A61K47/38A61K31/444A61P25/08
CPCA61K9/2054A61K9/2027A61K9/2031A61K31/444A61P25/08
Inventor 赵宇巍王宇杰
Owner BEIJING VENTUREPHARM BIOTECH