A kind of spiral polymer functionalized silica microsphere chiral stationary phase and its preparation and application

Abstract

The invention relates to the preparation of a helical polymer-functionalized silica gel microsphere chiral stationary phase (Chiral Separation Phase, CSP) and its application in chiral separation. Specifically, an alkynyl group is first introduced on the surface of the silica gel microspheres, and then a functional monomer (Fmoc-L-phenylalanine derivative) and a catalyst are added, and the monomer can undergo "alkynyl-alkynyl" addition under the action of the catalyst. A helical structure is formed through a polymerization reaction, thereby preparing a surface-modified helical polymer silica microsphere material. Since the functional monomer, Fmoc‑L‑phenylalanine derivative, itself has a chiral structure, the material can be used as a chiral Stationary phases are used for the separation of chiral compounds. The preparation process of the chiral stationary phase is simple, the reaction conditions are mild, and it can be used for large-scale preparation.

Description

Technical field [0001] The present invention involves the separation of the refinery. After modifying the surface of the silicon dioxide microspheres 3-巯 巯 炔 炔, add the function of the chemical reactive function and the catalyst. The polymer function of the polymer function of the spiral structure to the surface of the silicon ball to form a silicon -sophilic silicon microsphere of a single molecule function of the single molecular function of the single molecular function. Disassembling to refine. Background technique [0002] Hand nature is considered to be one of the key structural factors that perform a series of complex functions in nature, and exist in the biological process. Among them, spirals are one of its simplest and most important states. For example, the polypeptide chain that compose a protein and the deoxyucleotide that constitutes the DNA chain has a spiral structure. The discovery of the spiral structure has aroused the attention of scientists to synthesize the ...

AI Technical Summary

Problems solved by technology

Although chiral isomers have similar physical and chemical properties, they show great differences in distribution, metabolism, etc. in organisms

For example, in the famous "thalidomide (thalidomide)" incident, due to the backwardness of science and technology at that time, people did not fully understand the differences between chiral enantiomers, and could not separate and identify chiral compounds, which led to this huge tragedy.

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