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Application of C-JNK (JUN N terminal kinase) inhibitor SU3327

A C-JUNN, 1.C-JUNN technology, used in antifungal agents, resistance to vector-borne diseases, medical preparations containing active ingredients, etc., can solve problems such as affecting transcription

Active Publication Date: 2021-10-12
陈洪亮
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] Microvasc Res journal (2012Sep), titled Post-transcriptional regulation of placenta growth factor mRNA by hydrogen peroxide, main content: Oxidative stressors such as hydrogen peroxide can activate multiple kinase pathways, thereby affecting transcription, RNA stability and translation process

Method used

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  • Application of C-JNK (JUN N terminal kinase) inhibitor SU3327
  • Application of C-JNK (JUN N terminal kinase) inhibitor SU3327

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Embodiment Construction

[0017] Based on deep learning technology, the present invention automatically finds out potential new antibiotics from the existing or safe drug database in the clinical trial stage. The susceptibility test of bacteria confirmed that SU3327 has broad-spectrum antibiotic activity. The present invention provides a new type of antibiotic, which will have an important impact on the field of medicine.

[0018] 1. Using bacterial susceptibility tests to determine the susceptibility of SU3327 to Escherichia coli ATCC25922, Staphylococcus aureus CMCC (B) 26003, Staphylococcus aureus MRSA ATCC43300, Acinetobacter baumannii ATCC19606, Clostridium sporogenes CMCC (B) 64941, Bacillus subtilis The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of Bacillus CMCC (B) 63501 and Candida albicans ATCC10231. It can be seen from the experimental results that SU3327 has good antibacterial ability and can be used as a broad-spectrum antibiotic to effectively red...

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Abstract

The invention relates to an application of a C-JNK (JUN N terminal kinase) inhibitor SU3327. The C-JNK inhibitor SU3327 is used for bacteriostasis of different animal and human species. The C-JNK inhibitor SU3327 acts on strains isolated from humans or / and animals or clinically isolated from infected persons and then cultured to kill and inhibit bacteria.

Description

technical field [0001] The present invention relates to the use of a C-JUN N-terminal kinase (JNK) inhibitor SU3327. Background technique [0002] Antibiotics are the most effective drugs that humans have discovered from soil and metabolites of various microorganisms to treat bacterial infections. With the abuse of antibiotics, some bacteria have begun to develop resistance to antibiotics and become drug-resistant bacteria, which has increased the difficulty of treating human and animal diseases. In 2019, my country issued the "Antibiotic Ban" order for feed (Announcement No. 194), which clearly prohibits the use of feed additives containing growth-promoting drugs in the aquaculture industry, and actively promotes the aquaculture industry to achieve "antibiotic ban" in feed and "antibiotic reduction" in breeding. , The development direction of "antibiotic-free" products, encourage the development of safe and efficient new antibacterial drugs to replace traditional antibiotic...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/433A61P31/04A61P31/10A61P3/10
CPCA61K31/433A61P31/04Y02A50/30
Inventor 陈洪亮
Owner 陈洪亮
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