Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of C-JNK (JUN N terminal kinase) inhibitor SU3327

A C-JUNN, 1.C-JUNN technology, used in antifungal agents, resistance to vector-borne diseases, medical preparations containing active ingredients, etc., can solve problems such as affecting transcription

Inactive Publication Date: 2020-10-16
陈洪亮
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Microvasc Res journal (2012 Sep), titled Post-transcriptional regulation of placenta growth factor mRNA by hydrogen peroxide, main content: Oxidative stressors such as hydrogen peroxide can activate multiple kinase pathways, thereby affecting transcription, RNA stability and the translation process

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of C-JNK (JUN N terminal kinase) inhibitor SU3327
  • Application of C-JNK (JUN N terminal kinase) inhibitor SU3327

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0014] Based on the deep learning technology, the present invention automatically finds potential new antibiotics from the existing or safe drug database in the clinical trial stage. The susceptibility test of bacteria confirmed that SU3327 has broad-spectrum antibiotic activity. The invention provides a novel antibiotic, which further brings important influence to the field of medicine.

[0015] Bacterial susceptibility tests were used to determine the susceptibility of SU3327 to Escherichia coli ATCC25922, Staphylococcus aureus CMCC (B) 26003, Staphylococcus aureus MRSA ATCC43300, Acinetobacter baumannii ATCC19606, Clostridium sporogenes CMCC (B) 64941, Bacillus subtilis CMCC (B) Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of 63501, Candida albicans ATCC10231. It can be seen from the experimental results that SU3327 has good antibacterial ability and can be used as a broad-spectrum antibiotic to effectively reduce the mortality rate o...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to an application of a C-JNK (JUN N terminal kinase) inhibitor SU3327. The C-JNK inhibitor SU3327 is used for bacteriostasis of different animal and human species. The C-JNK inhibitor SU3327 acts on strains isolated from humans or / and animals or clinically isolated from infected persons and then cultured to kill and inhibit bacteria.

Description

technical field [0001] The invention relates to the use of SU3327, a C-JUN N-terminal kinase (JNK) inhibitor. Background technique [0002] Antibiotics are the most effective drugs that humans have discovered from soil and metabolites of various microorganisms to treat bacterial infections. With the abuse of antibiotics, some bacteria have begun to develop resistance to antibiotics and become drug-resistant bacteria, which has increased the difficulty of treating human and animal diseases. In 2019, my country issued the "Antibiotic Ban" order for feed (Announcement No. 194), which clearly prohibits the use of feed additives containing growth-promoting drugs in the aquaculture industry, and actively promotes the aquaculture industry to achieve "antibiotic ban" in feed and "antibiotic reduction" in breeding. , The development direction of "antibiotic-free" products, encourage the development of safe and efficient new antibacterial drugs to replace traditional antibiotics. As ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/433A61P31/04A61P31/10A61P3/10
CPCA61K31/433A61P31/04A61P31/10A61P3/10Y02A50/30
Inventor 陈洪亮
Owner 陈洪亮
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com