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Modified carbon nanomaterial, nanocluster, substance delivery carrier and pharmaceutical composition

A technology of carbon nanomaterials and nanoclusters, which is applied in the field of modified carbon nanomaterials, material delivery carriers and pharmaceutical compositions, and nanoclusters. It can solve the problems of lack of CND self-assembly ability and achieve excellent solubility.

Pending Publication Date: 2021-10-26
NAT INST OF ADVANCED IND SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the prior art, it is basically focused on improving the dispersibility of CNDs, and there is no evaluation related to the self-assembly ability of CNDs after surface chemical modification, and nanometers for the purpose of loading drugs. Research related to structural control

Method used

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  • Modified carbon nanomaterial, nanocluster, substance delivery carrier and pharmaceutical composition
  • Modified carbon nanomaterial, nanocluster, substance delivery carrier and pharmaceutical composition
  • Modified carbon nanomaterial, nanocluster, substance delivery carrier and pharmaceutical composition

Examples

Experimental program
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Effect test

Embodiment 1

[0099]

[0100] 1. Synthesis of superparticle complexes that make full use of carboxylated nanodiamonds

[0101] Carboxylated nanodiamond (NDc) (particle size: 4-5nm) was prepared by detonation method according to the description of JP-A-2017-202940 or JP-A-2016-113333. The synthesized NDc was purified by nitric acid and fired under hydrogen atmosphere. The elemental analysis of NDc was carried out using an organic elemental analysis device (Micro Corder JM10; J-Science Lab Co., Ltd, Kyoto, Japan). As a result, C (86.92%), H (0.44%), and N (2.29%) were found. The purified NDc was dispersed in distilled water using a bead mill (Sand Grinder LSG-4U; Aimex Co., Ltd, Tokyo, Japan). Next, the NDc-dispersed aqueous solution is centrifuged to remove water-insoluble NDs. The resulting supernatant solution (NDc-ori) was used in subsequent experiments. Dissolve 1ml of NDc-ori in aqueous solution (ND concentration = 56mg ml -1 ), arbitrary terminal aminated alkyl molecules (50 μl o...

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Abstract

The present invention provides a nanocluster which is composed of self-assembled carbon nanomaterials that are modified with higher alkyl groups or higher alkenyl groups.

Description

technical field [0001] The invention relates to modified carbon nanomaterials, nanoclusters, substance delivery carriers and pharmaceutical compositions. [0002] The following symbols are used in this manual: [0003] NDc: carboxylated nano diamond [0004] ND: nano diamond (nano diamond) [0005] NDc-ori: unmodified carboxylated nanodiamond raw material [0006] SP: super particle [0007] NDc-SP: nanoclusters of carboxylated nanodiamonds modified with alkyl groups [0008] PEG: polyethylene glycol [0009] PEGMEM: Polyethylene glycol methyl ether methacrylate [0010] DSPE: Distearoylphosphatidylethanolamine [0011] F127: Pluronic F127 [0012] CPT: camptothecin [0013] PTX: Paclitaxel Background technique [0014] In addition to the inherent properties of diamond, carbon nanodiamond (hereinafter referred to as "CND") also has the characteristics of small average particle size and large specific surface area, and has the advantages of being relatively cheap an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B82Y5/00B82Y30/00B82Y40/00A61K9/51A61K47/04C01B32/15C01B32/28
CPCB82Y30/00C01B32/15C01B32/28A61K9/143A61K9/146A61K47/10A61K9/0019A61K9/51B82Y5/00B82Y40/00A61K9/5115C01B32/26
Inventor 都英次郎于跃西川正浩刘明郑贵宽
Owner NAT INST OF ADVANCED IND SCI & TECH