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Atropine separated and purified from alkaloid extract and preparation method thereof

A technology of separation and purification and alkaloids, applied in the direction of organic chemistry, can solve the problems of sewage treatment pressure, inability to pass chemical synthesis, waste of resources, etc., to reduce waste, promote industrial development, and save resources.

Pending Publication Date: 2021-10-29
锦州拾正生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Scopolamine hydrobromide is optically active and cannot be chemically synthesized. At present, it can only be extracted from medicinal materials
However, after extracting scopolamine hydrobromide from medicinal materials, the remaining solution contains more scopolamine (atropine can be obtained after racemization), if it is directly discarded, it will not only cause waste of resources, but also bring pressure to sewage treatment

Method used

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preparation example Construction

[0014] On the one hand, the present invention provides a preparation method for separating and purifying atropine from alkaloid extract, comprising the following steps: obtaining alkaloid extract from Huashan ginseng by leaching, extracting alkaloid extract with chloroform, and recovering under reduced pressure Chloroform is used to obtain intermediate 1, and intermediate 1 uses the mixed solution of ethyl acetate / methanol / concentrated ammonia water as a developer to separate out the stock solution, and the stock solution is refluxed at a temperature of 90-100°C for 3-6 hours to obtain intermediate 2, and intermediate Body double crystallization to obtain the crude product, crude product decolorization to obtain atropine.

[0015] Impregnating Huashan ginseng with the extracting solution to extract the effective components in the extracting solution, and then filtering and concentrating to obtain the alkaloid extract. Hyoscyamine is easily soluble in chloroform, so the alkaloi...

Embodiment 1

[0027] The embodiment of the present invention proposes a preparation method for separating and purifying atropine from alkaloid extract, comprising the following steps:

[0028] Extraction of alkaloids: use ethanol with a volume fraction of 80% vol to impregnate Huashan ginseng at a temperature of 40°C, then filter to obtain the filtrate and filter residue, then add the above-mentioned ethanol to the filter residue for impregnation and filter again. Perform extraction.

[0029] Preparation of alkaloid extract: use the above method to extract Huashan ginseng 4 times, then combine the filtrates, concentrate the mixed filtrate under reduced pressure to obtain extracts, adjust the pH of the extracts to 3, let stand for 6 hours, and then adjust After the pH was set to 10 and left to stand for 6 hours, the original solution was obtained, and the original solution was extracted with chloroform, then concentrated under reduced pressure, and the chloroform was recovered to obtain an a...

Embodiment 2

[0034] The embodiment of the present invention proposes a preparation method for separating and purifying atropine from alkaloid extract, comprising the following steps:

[0035] Extraction of alkaloids: use ethanol with a volume fraction of 70% vol to impregnate Huashan ginseng at a temperature of 35°C, then filter to obtain the filtrate and filter residue, then add the above-mentioned ethanol to the filter residue for impregnation and filter again, such a cycle operation is effective for Huashan ginseng Perform extraction.

[0036] Preparation of alkaloid extract: use the above method to leach Huashan ginseng 3 times, then combine the filtrates, concentrate the mixed filtrate under reduced pressure to obtain extracts, adjust the pH of the extracts to 1, let stand for 5 hours, and then adjust The original solution was obtained after the pH reached 9 and left to stand for 5 hours, and the original solution was extracted with chloroform, then concentrated under reduced pressure...

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PUM

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Abstract

The invention provides atropine separated and purified from alkaloid extract and a preparation method of the atropine, and relates to the technical field of pharmaceutical preparations. According to the preparation method for separating and purifying the atropine from the alkaloid extract, scopolamine remained in the alkaloid extract is secondarily utilized, and the purity of the atropine is improved, so that on one hand, the economic benefit can be improved, the industrial development can be promoted, and the waste of raw medicinal materials can be reduced; on the other hand, compared with a synthesis method, damage to the environment is reduced. The invention further relates to atropine, and the atropine is good in quality and physiological activity, high in purity, good in medicinal effect and high in medical value.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to atropine separated and purified from alkaloid extract and a preparation method thereof. Background technique [0002] Atropine is an anticholinergic drug that acts on M-choline receptors, blocks it, and has a wide range of pharmacological effects, for example, on smooth muscle: Atropine has a relaxing effect on smooth muscle. The functional state of visceral smooth muscle has a great influence on the dosage and intensity of atropine, and smooth muscle with normal activity is less affected by atropine; but in the state of smooth muscle spasm or contraction, atropine has a significant effect. The effects of atropine on gastrointestinal smooth muscle, bladder detrusor smooth muscle, bile duct and bronchial smooth muscle were weakened sequentially. The effect of atropine on glands: it can inhibit the secretion of major glands in animals, and patients often feel t...

Claims

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Application Information

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IPC IPC(8): C07D451/10
CPCC07D451/10
Inventor 刘千驰于喜洋刘东滨
Owner 锦州拾正生物科技有限公司
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