Cation defect type ZIF porous material as well as preparation method and application thereof

Abstract

The invention provides a cation defect type ZIF porous material as well as a preparation method and application thereof, and belongs to the technical field of functional adsorption materials. The preparation method of the cation defect type ZIF porous material comprises the following steps: in an organic solvent, mixing an imidazole compound with iodomethane to react to obtain an imidazolyl cation ligand; and dissolving the obtained imidazolyl cation ligand and an imidazole compound in water, adding a metal salt, uniformly mixing, and standing for reaction to obtain the cation defect type ZIF porous material. The obtained cation defect type ZIF porous material is applied to iodine adsorption. The synthesis method is simple, low in cost and high in iodine adsorption efficiency.

Description

technical field [0001] The invention belongs to the technical field of functional adsorption materials, in particular to a cation-deficient ZIF porous material and its preparation method and application. Background technique [0002] Nuclear energy, as a green and reliable energy source, has become more and more important as the world's energy demand increases. However, the hazard of radioactive nuclear waste released into the environment is also one of the important issues to be considered in drug management in the nuclear energy industry. Among the many radioactive elements, radioactive iodine presents unique exposure concerns. Elemental iodine (I 2 ) has high fluidity due to its easy sublimation (45°C), and its isotope 129 I and 131 I also had unique exposure problems. 129 I is an extremely long-lived isotope with a half-life of 1.57×10 7 years, must be captured and reliably stored during its decay, and 131 I has a half-life of only 8.02 days, but it needs to be ca...

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Problems solved by technology

[0009] Existing Materials for Radioactive I 2 There are many problems or deficiencies in the adsorption and storage of the following aspects: (1) low storage capacity (such as activated carbon); (2) large pores of the material, which is not conducive to long-term storage (such as Zn 3 (DL-lac) 2 (pybz) 2 ); (3) the organic ligand cost of the synthetic MOF material used is higher, the synthesis condition is harsh (as MFM-300 series); (4) I 2 Only in simple substance (I 2 ) form storage, not conducive to long-term preservation (such as ZIF-8); (5) due to the non-polar I 2 The binding effect with the adsorbent is weak, and the binding site is unstable, which can lead to the further release of iodine. It is difficult for the existing capture methods to firmly fix I 2

[0012] Most of the existing nanoparticle carriers transport drugs through simple physical embedding or adsorption. Before reaching the tumor site, the drug will fall off from the carrier, so the drug load will be reduced.

In addition, most nanoparticles have poor biocompatibility and cannot easily pass through the cell membrane of tumor cells, resulting in low tumor cell internalization rate.

In addition, the vast majority of nanoparticles are not targeted to tumor cells or organelles, and need to be modified with targeting functional groups, which makes the synthesis difficult

At the same time, since a single treatment mode has a low lethality to tumor cells, a combination of multiple treatment modes, such as chemotherapy and photodynamic therapy, is required to have a high lethality to tumor cells, which leads to synthetic cost too high

[0013] Aiming at the technical problems in the existing technology: including tumor cell targeting, tumor toxicity, carrying of SiRNA, transportation of anticancer drugs and synthesis cost of nanoparticles, etc., a new technical solution is urgently needed to solve this problem

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