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Preparation method of drug sustained-release body and drug sustained-release body

A slow-release body and drug technology, which is applied in the preparation of drug slow-release body and the field of drug slow-release body, can solve the problems of reducing the drug action time and the position of drug diffusion can not be effectively presented

Pending Publication Date: 2021-11-02
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, in the process of ultrasound guidance, although the accuracy of puncture can be improved by displaying the position of the puncture needle, the position of drug diffusion during and after injection cannot be effectively displayed.
In addition, the injection of large doses of local anesthetic drugs may cause uncontrollable nerve damage, and excessive drug metabolism will also reduce the drug's action time

Method used

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  • Preparation method of drug sustained-release body and drug sustained-release body
  • Preparation method of drug sustained-release body and drug sustained-release body
  • Preparation method of drug sustained-release body and drug sustained-release body

Examples

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preparation example Construction

[0052] see figure 1 , the present invention claims a kind of preparation method of medicine slow-release body, and described method comprises:

[0053] Step S101, preparing a micron-scale spherical structure. According to the difference of the spherical structure, preferably, the spherical structure comprises: a uniform spherical structure (see figure 2 ) and / or hollow sphere structures (see image 3 ). Wherein, the shell thickness of the hollow sphere structure is 10%-50% of the diameter of the sphere, for example: 10%, 25% or 50%.

[0054] When the molecular structure of the sphere is loose, there will be some small pores, and these small pores make the air inside the sphere have a relatively large difference in acoustic resistance from the surrounding tissue, which is conducive to enhancing the scattering of ultrasonic waves. Therefore, it is preferable to use one of polylactic acid-glycolic acid copolymer, silk fibroin or chitosan with suitable internal structure as t...

Embodiment 1

[0062] The preparation method of the ultrasonic imaging drug slow-release body based on the uniform spherical structure of silk fibroin comprises the following steps:

[0063] a1) ① Preparation of silk fibroin prepolymer solution

[0064] Silk fibroin is extracted from the cocoons of silkworms. Dissolving the freeze-dried silk fibroin in a hexafluoroisopropanol solvent to prepare a silk / hexafluoroisopropanol solution;

[0065] Afterwards, a required volume of deionized water was slowly dropped into 3ml of 15% w / v silk / hexafluoroisopropanol solution, and the two were thoroughly mixed by gently swirling to obtain a silk fibroin prepolymer solution.

[0066] ②Preparation of monodisperse silk fibroin microspheres by microfluidic technology

[0067] The silk fibroin prepolymer solution is used as the microfluidic water phase, and n-hexadecane containing a surfactant is used as the external phase to collect the generated droplets;

[0068] The droplets are stored in a glass conta...

Embodiment 2

[0074] The preparation method of the ultrasonic imaging drug sustained release body based on the hollow structure of the polylactic acid-glycolic acid material comprises the following steps:

[0075] a2) Preparation of polylactic acid-glycolic acid microspheres with hollow structure

[0076] Add 0.3g of polylactic acid-glycolic acid to 6ml of dichloromethane solvent, mix well, add 4ml of water, and stir at high speed for 1 hour;

[0077] Add 50ml of 1% polyvinyl alcohol solution and stir overnight at low speed to obtain polylactic acid-glycolic acid microspheres with hollow structure;

[0078] The polylactic acid-glycolic acid hollow microspheres are centrifuged. Preferably, the centrifugation speed is 3000 rpm for 5 minutes.

[0079] The polylactic acid-glycolic acid hollow microspheres were rinsed three times with deionized water, and then freeze-dried in a freeze dryer to sublimate and encapsulate the frozen water.

[0080] The obtained polylactic acid-glycolic acid holl...

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Abstract

The invention discloses a preparation method of a drug sustained-release body. The preparation method comprises the following steps: a) preparing a micron-sized sphere structure; b) binding the sphere structure to drug molecules; c) drying the combination of the sphere structure and the drug molecules to obtain a drug sustained-release body, wherein in the sphere structure, the diameter of the sphere is between 1 [mu]m and 50 [mu]m; the sphere structure comprises a uniform sphere structure and / or a hollow sphere structure. Correspondingly, the invention also provides a drug sustained-release body prepared by adopting the preparation method. After entering the body, the drug sustained-release body provided by the invention effectively realizes development under ultrasound by utilizing the scattering effect of the drug sustained-release body on mechanical waves; the action position of the drug can be accurately positioned through ultrasonic development of the drug sustained-release body, the action time of the drug can be prolonged through the sustained-release effect of the drug sustained-release body, and the accuracy of nerve block treatment and the bioavailability of the drug are improved.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a preparation method of a drug slow-release body and the drug slow-release body. Background technique [0002] Nerve blocks are a major means of effective treatment of a variety of acute and chronic pain. Inject local anesthetics around nerve trunks, plexuses, and nodes to block their impulse conduction and anesthetize the innervated area, which is called nerve block. Nerve blocks require only one injection to obtain a larger area of ​​anesthesia. However, this operation may cause serious complications. Therefore, it is necessary to be familiar with the local anatomy, understand the tissues that the puncture needle will pass through, and nearby blood vessels, organs, and body cavities. Ultrasound-guided nerve block uses real-time ultrasound to clearly display most of the peripheral nerves and their surrounding anatomical structures to precisely position...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/167A61K31/445A61K47/34A61K47/36A61K47/42A61K47/59A61K47/61A61K47/64A61K47/69
CPCA61K47/61A61K47/593A61K47/64A61K47/6927A61K47/6925A61K47/42A61K47/36A61K47/34A61K31/167A61K31/445A61K9/1658A61K9/1647
Inventor 杨建军刘盼苗叶皓天尚会杰
Owner THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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