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Preparation method of medicine porous sustained-release body and medicine porous sustained-release body

A slow-release, drug-based technology, applied in drug combinations, pharmaceutical formulations, medical preparations with non-active ingredients, etc., can solve the problems that the position of drug diffusion cannot be effectively displayed, and the drug's action time can be reduced.

Pending Publication Date: 2021-11-26
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, in the process of ultrasound guidance, although the accuracy of puncture can be improved by displaying the position of the puncture needle, the position of drug diffusion during and after injection cannot be effectively displayed.
In addition, the injection of large doses of local anesthetic drugs may cause uncontrollable nerve damage, and excessive drug metabolism will also reduce the drug's action time

Method used

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  • Preparation method of medicine porous sustained-release body and medicine porous sustained-release body
  • Preparation method of medicine porous sustained-release body and medicine porous sustained-release body
  • Preparation method of medicine porous sustained-release body and medicine porous sustained-release body

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preparation example Construction

[0056] see figure 1 , the present invention claims to protect a preparation method of a drug porous sustained-release body, the method comprising:

[0057] In step S101, a micron-scale porous spherical structure is prepared. Because the molecular structure of the sphere is loose, there will be some small pores, and these small pores make the air inside the porous sphere with a relatively large difference in acoustic resistance from the surrounding tissue, which is conducive to enhancing the scattering effect of ultrasonic waves. One of polylactic acid-glycolic acid copolymer, silk fibroin or chitosan is used as the spherical material in the porous spherical structure.

[0058] Preferably, in the porous sphere structure, the diameter of the sphere is between 1 μm and 50 μm, for example: 1 μm, 25 μm or 50 μm.

[0059] In addition, according to the size and uniformity of the pore size in the porous spherical structure, the porous spherical structure in the present invention inc...

Embodiment 1

[0065] When the porous spherical structure is a uniform mesoporous spherical structure based on polylactic acid-glycolic acid copolymer material, the preparation method includes the following steps:

[0066] a1) Preparation of polylactic acid-glycolic acid porous spherical structure: add 0.3g of polylactic acid-glycolic acid and Pluronic nonionic surfactant (F127) into 6ml of dichloromethane solvent, and add 50ml of 1% polyethylene after mixing evenly The alcohol solution was stirred at low speed overnight to obtain polylactic acid-glycolic acid hollow microspheres containing surfactant.

[0067] The polylactic acid-glycolic acid hollow microspheres were processed by centrifugation. Preferably, the centrifugal speed is 3000 rpm, and the centrifugal treatment is performed for 5 min.

[0068] The polylactic-glycolic acid hollow microspheres were rinsed three times with absolute ethanol and subjected to critical point drying. The dried hollow microspheres were stored at 4°C for...

Embodiment 2

[0073] When the porous sphere structure is a uniform macroporous sphere structure based on silk fibroin material, the preparation method includes the following steps:

[0074] a2) Preparation of silk fibroin porous sphere structure:

[0075] To prepare silica microspheres:

[0076] ① Preparation of monodisperse silica nanoparticles:

[0077] Water, ethyl orthosilicate, arginine, and cyclohexane are uniformly mixed to prepare silicon dioxide nanoparticles with monodispersity and a size of 10 nm to 20 nm; the silicon dioxide nanoparticle solution is dispersed in In the seed growth reaction system constructed by ethanol and ammonia water; while stirring uniformly, slowly drop the silica precursor solution to obtain monodisperse silica particles of the desired size (such as 200 nm);

[0078] ②Preparation of silica microspheres:

[0079] The monodispersed 200nm silica nanoparticles were centrifuged and purified, and the proportion of the colloidal nanoparticles in the nanopartic...

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Abstract

The invention discloses a preparation method of a medicine porous sustained-release body. The method comprises the following steps of a) preparing a micron-sized porous sphere structure; b) combining the porous sphere structure with medicine molecules; and c) drying the combination of the porous sphere structure and the medicine molecules to obtain the medicine porous sustained-release body, wherein the porous sphere structure comprises a uniform macroporous sphere structure, a uniform mesoporous sphere structure and a non-uniform porous sphere structure. Correspondingly, the invention further provides the medicine porous sustained-release body prepared by using the preparation method. After entering the body, the medicine porous sustained-release body effectively realizes development under ultrasound by utilizing the scattering effect of the medicine porous sustained-release body on mechanical waves; and the action position of the medicine can be accurately positioned through ultrasonic development of the medicine porous sustained-release body, the action time of the medicine can be prolonged through the sustained-release effect of the medicine porous sustained-release body, and the accuracy of nerve block treatment and the bioavailability of the medicine are improved.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a preparation method of a drug porous sustained-release body and the drug porous sustained-release body. Background technique [0002] Nerve blocks are a major means of effective treatment of a variety of acute and chronic pain. Inject local anesthetics around nerve trunks, plexuses, and nodes to block their impulse conduction and anesthetize the innervated area, which is called nerve block. Nerve blocks require only one injection to obtain a larger area of ​​anesthesia. However, this operation may cause serious complications. Therefore, it is necessary to be familiar with the local anatomy, understand the tissues that the puncture needle will pass through, and nearby blood vessels, organs, and body cavities. Ultrasound-guided nerve block uses real-time ultrasound to clearly display most of the peripheral nerves and their surrounding anatomical structur...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K47/34A61K47/36A61K47/42A61K47/04A61K31/445A61P23/02A61K31/167
CPCA61K9/146A61K47/34A61K47/42A61K47/36A61K9/143A61K31/445A61P23/02A61K31/167
Inventor 杨建军刘盼苗叶皓天尚会杰
Owner THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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