A probiotic composition and its application in the preparation of comorbid constipation and depression medicine

A technology of probiotics and composition, applied in the field of probiotics, can solve problems such as large differences in effects, and achieve the effect of relieving depression symptoms

Active Publication Date: 2021-12-07
CHINA AGRI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the problem that the probiotics in the prior art have large differences in the effect of improving the depressive symptoms of patients, and provide a probiotic composition and its application in the preparation of comorbid constipation and depression drugs. Bacterial composition can effectively relieve depressive symptoms in depressed people with comorbid constipation

Method used

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  • A probiotic composition and its application in the preparation of comorbid constipation and depression medicine
  • A probiotic composition and its application in the preparation of comorbid constipation and depression medicine
  • A probiotic composition and its application in the preparation of comorbid constipation and depression medicine

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Embodiment 1

[0034] The present embodiment provides a kind of probiotic composition, and described composition is made of Bifidobacterium animalis subsp. lactis ( Bifidobacterium animalis subsp. lactis ) U9, Lactobacillus paracasei ( Lactobacillus paracasei ) L55, Lactobacillus rhamnosus ( Lactobacillus rhamnosus ) LL23, Bifidobacterium adolescentis ( Bifidobacterium adolescentis ) BQ23, and Lactobacillus acidophilus ( Lactococcus acidophilus ) RA15 composition, each bacterial powder weighs 2g, and each bacterial content is 3×10 10 CFU;

[0035] The animal Bifidobacterium lactis subspecies U9 was deposited in the General Microorganism Center of China Microbiological Culture Collection Management Committee on November 04, 2015, and the preservation number is CGMCC NO. 11560;

[0036] The Lactobacillus paracasei L55 was deposited in the General Microorganism Center of China Microbiological Culture Collection Management Committee on April 07, 2017, and the preservation number is CG...

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Abstract

The invention provides a probiotic composition and its application in the preparation of comorbid constipation and depression medicines, said composition comprising Bifidobacterium animalis subspecies U9, Lactobacillus paracasei L55, Lactobacillus rhamnosus LL23 , Bifidobacterium adolescentis BQ23 and Lactobacillus acidophilus RA15. The present invention has carried out a randomized double-blind test to perform probiotic intervention on depressed patients. A total of 63 depressed patients were recruited, 31 of whom had comorbid constipation. The results showed that after 8 weeks of intervention, the Hamilton depression (HAMD) score of the probiotic group decreased to 14.2±8.0 in the depressed group with comorbid constipation, which was significantly lower than that in the placebo group (22.9±9.9, P<0.05). There was no significant difference in HAMD scores between the population probiotic group and the placebo group. The probiotic composition of the invention can effectively alleviate the depression symptoms of depressed people with comorbid constipation.

Description

technical field [0001] The invention belongs to the technical field of probiotics, and in particular relates to a probiotic composition and its application in preparing medicines for comorbid constipation and depression. Background technique [0002] Depression is a common and dangerous mental illness. According to the report of the World Health Organization, patients with depression accounted for about 4.4% of the total population in 2015, and the total number of patients was as high as 322 million. Although both depression and constipation can occur independently, studies have shown a high rate of comorbidity between the two. It is reported that 57.7% of depressed patients are accompanied by constipation symptoms, and their probability of suffering from constipation is 1.8 times that of ordinary people. Patients with gastrointestinal disorders were also more likely to suffer from depression, with a prevalence as high as 33 percent among chronic constipation patients. It...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N1/20A23L33/135A61K35/745A61K35/747A61P1/10A61P25/24C12R1/01C12R1/225C12R1/23
CPCC12N1/20A23L33/135A61K35/745A61K35/747A61P1/10A61P25/24A23V2002/00A23V2400/165A23V2400/513A23V2400/515A23V2400/175A23V2400/113A23V2200/3204A23V2200/322A61K2300/00
Inventor 任发政陈善斌王然李依璇任怡镁
Owner CHINA AGRI UNIV
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