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Pharmaceutical composition for improving and treating leukotrichia and/or alopecia and preparation method thereof

A composition and drug technology, applied in the pharmaceutical composition for improving and treating gray hair and/or hair loss, the preparation field of the pharmaceutical composition can solve side effects, unreported glucosinolate biological activity, poor effect, etc. problems, to promote hair growth, improve and treat gray hair and/or hair loss, and stop progression

Pending Publication Date: 2021-11-26
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this document has not done in-depth research on the effect of the composition on melanocytes and tyrosinase, and its effect on preventing black hair from turning white is not good, and there may be potential side effects
[0007] Non-Patent Document 1 also introduced that glucoraphanin, as a kind of glucosinolate, can be extracted from natural products such as Chinese medicine radish seed and radish seed, but the biological activity of glucosinolate on human body has not been reported so far. The biological activity of a substance is often reflected in its degradation products

Method used

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  • Pharmaceutical composition for improving and treating leukotrichia and/or alopecia and preparation method thereof
  • Pharmaceutical composition for improving and treating leukotrichia and/or alopecia and preparation method thereof
  • Pharmaceutical composition for improving and treating leukotrichia and/or alopecia and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0054]

[0055] A. Crushing the raw materials

[0056] Using a pulverizer to pulverize one or more of the seeds, flowers, stems and leaves of cruciferous plants as raw materials, and collect the pulverized matter.

[0057] B. Extraction of glucoraphanin

[0058] After heating the deionized water to boiling, add the pulverized product obtained in step A according to the solid-to-liquid ratio of 1:5 to 1:50, extract with boiling water for 10 to 30 minutes, and filter with filter cloth to obtain the water extract. Repeat the extraction once, and collect the obtained glucoraphanin water extract.

[0059] Determine the amount of activated carbon according to the mass ratio of activated carbon to glucoraphanin water extract of 10:1 to 10:5, add the water extract to activated carbon, stir and adsorb at a temperature of 0 to 50°C for 10 to 60 minutes, and filter An activated carbon filter cake adsorbed with glucoraphanin is obtained. The activated carbon filter cake is mixed with...

Embodiment 1

[0097] Example 1 Preparation of Granule 1 Containing Glucoraphanin and Myrosinase

[0098] Take 200g of the glucoraphanin extract prepared by the above method I. (the purity of glucoraphanin is 95%) and 19.8kg of dextrin are mixed and dissolved in 100L of deionized water, and then spray-dried. The air inlet temperature of the spray drying was set to 180°C, the outlet air temperature was adjusted to 80°C, the liquid inlet speed was 5L / h, the product was collected, and the glucoraphanin spray-dried powder was prepared. Take 200mg of the myrosinase extract prepared by the above-mentioned method II. and 19.8kg of dextrin are mixed and dissolved in 100L of deionized water, and then spray-dried. The air inlet temperature of spray drying was set to 180°C, the outlet air temperature was adjusted to 80°C, and the liquid inlet speed was 5L / h. The product was collected to prepare myrosinase spray-dried powder. The glucoraphanin spray-dried powder and the myrosinase spray-dried powder ...

Embodiment 2

[0099] Example 2 Preparation of Granule 2 Containing Glucoraphanin and Myrosinase

[0100] Take 300g of the glucoraphanin extract prepared according to the above method I. (the purity of glucoraphanin is 92%) and 4.7kg of dextrin are mixed and dissolved in 2.5L of deionized water, and then spray-dried. The air inlet temperature of the spray drying was set to 180°C, the outlet air temperature was adjusted to 80°C, the liquid inlet speed was 5L / h, the product was collected, and the glucoraphanin spray-dried powder was prepared. Take 300 mg of the myrosinase extract prepared by the above method II. and 4.7 kg of dextrin, mix and dissolve in 2.5 L of deionized water, and then spray dry. The air inlet temperature of spray drying was set to 180°C, the outlet air temperature was adjusted to 80°C, and the liquid inlet speed was 5L / h. The product was collected to prepare myrosinase spray-dried powder. The spray-dried powder of glucoraphanin and the spray-dried powder of myrosinase w...

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Abstract

The invention relates to a pharmaceutical composition for improving and treating leukotrichia and / or alopecia and a preparation method thereof. The pharmaceutical composition comprises glucoraphanin and myrosinase as effective components, based on the total weight of the pharmaceutical composition, the content of glucoraphanin is 0.1-50%, and the total enzyme activity of myrosinase is 0.1 mU to 10U. The pharmaceutical composition provided by the invention has the characteristics of safety, rapidness, effective improvement and treatment of leukotrichia and / or alopecia, wide subject application range and the like.

Description

technical field [0001] The present invention relates to a pharmaceutical composition for improving and treating gray hair and / or alopecia, which contains glucoraphanin and myrosinase as active ingredients. The invention also relates to a preparation method of the pharmaceutical composition. Background technique [0002] White hair can be divided into physiological white hair and pathological white hair. Physiological white hair is aging white hair, and pathological white hair can be divided into nutritional and metabolic white hair, chemical white hair, hereditary white hair and so on. [0003] Alopecia is divided into normal physiological alopecia and pathological alopecia. Normal hair loss can keep the hair entering the catagen phase and the hair newly entering the growth phase in a dynamic balance, so it can maintain a normal amount of hair, but pathological hair loss can cause abnormal or excessive hair loss. The causes of pathological alopecia are more complicated, i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/47A61K31/7028A61P17/14A61P17/00
CPCA61K38/47A61K31/7028A61P17/14A61P17/00C12Y302/01147A61K2300/00
Inventor 袁其朋程立刘朋涛
Owner BEIJING UNIV OF CHEM TECH
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