Pharmaceutical composition and application thereof
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A composition and drug technology, applied in the field of medicine, to achieve the effects of good safety and obvious synergistic effect
Active Publication Date: 2021-11-30
BINZHOU MEDICAL COLLEGE
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Analysis of the reason may be: under normoxic conditions, Na 2 SO 3 Metabolized H 2 Se is rapidly oxidized by oxygen to generate reactive oxygen species to promote cell death, however, under hypoxic conditions, due to insufficient oxygen, H 2 Se cannot be completely oxidized into reactive oxygen species, thus delaying cell death
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Embodiment 1
[0034] Example 1 Effects of Selenium Compounds Combined with Oxygen Therapy on Tumors in Mice
[0035] After 3 days of modeling, the treatment was given by intragastric administration of drug aqueous solution at regular intervals every day, and Na 2 SeO 3 and CysSeSeCys therapeutic concentrations of 2mg / kg and 5mg / kg, immediately after selenide gavage to 95% O 2 Oxygen inhalation in the environment for 4h.
[0036](1) sodium selenite experimental group: respectively Solvent, O 2 、Na 2 SeO 3 2mg / kg, Na 2 SeO 3 2mg / kg+O 2 、Na 2 SeO 3 5mg / kg, Na 2 SeO 3 5mg / kg+O 2 .
[0037] Experimental results such as figure 1 As shown in A and 1B, Na 2 SeO 3 2mg / kg+O 2 group with Na 2 SeO 3 Compared with the 2mg / kg treatment group, the tumor volume was reduced by 50.4%; Na 2 SeO 3 5mg / kg+O 2 group with Na 2 SeO 3 Compared with the 5mg / kg treatment group, the tumor volume was reduced by 40.6%;
[0038] (2) Selenocystine experimental group: Solvent, O 2 , CysSeS...
Embodiment 2
[0041] Example 2 Effects of Selenium Compounds Combined with Losartan on Tumors in Mice
[0042] O-based 2 The treatment can improve the therapeutic effect of selenium compounds on liver cancer, and the small molecule drug Losartan (Losartan) is used as a drug model. The concentration of losartan is 40mg / kg, and it is treated with two kinds of selenides by intragastric administration respectively. After 15 days of continuous treatment, the tumor size was measured and the mouse tumors were dissected to observe the therapeutic effect.
[0043] (1) Sodium selenite combined with losartan experimental group:
[0044] This experiment is divided into 6 groups, namely Solvent, Losartan, Na 2 SeO 3 2mg / kg, Na 2 SeO 3 2mg / kg+Losartan, Na 2 SeO 3 5mg / kg, Na 2 SeO 3 5mg / kg+Losartan. Experimental results such as figure 1 C, as shown in 1D, Na 2 SeO 3 2mg / Kg+Losartan and Na 2 SeO 3 Compared with 2mg / Kg, the tumor volume was reduced by 47.9%; Na 2 SeO 3 2mg / Kg+Losartan...
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Abstract
The invention belongs to the technical field of medicines, and particularly relates to a pharmaceutical composition containing a selenium compound and a vasodilator and application thereof. The selenium compound and the vasodilator are combined for the first time to be used for anti-tumor treatment, the vasodilator is used as an oxygen producer, the hypoxia microenvironment inside a tumor is improved, a natural barrier, caused by the hypoxia microenvironment inside the tumor, of tumor cells to selenide drug resistance is removed, and then the anti-tumor synergistic effect is achieved. Sodium selenite or selenocystine combined with losartan is used as a model drug to be used for liver cancer treatment, the two drugs are combined to show a remarkable synergistic treatment effect, meanwhile, other obvious visible side effects are not generated, safety is good, and more clinical application value and research ideas are provided for traditional drugs. The synergistic effect of combined losartan on the low-concentration selenium compound is particularly obvious, and more ideas are provided for developing low-concentration selenium compound drugs.
Description
technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition comprising a selenium compound and a vasodilator and an application thereof. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Selenium is an essential trace element for the human body, which has the function of preventing and treating cancer. A variety of selenium-containing compounds such as selenite (Selenite), selenocystine (CysSeSeCys), etc. have been proven to have anti-cancer effects. When these selenium compounds are metabolized in the body, a common intermediate metabolite hydrogen selenide (H 2 Se). h 2 Se is a highly activ...
Claims
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