A pharmaceutical composition for treating psoriasis

A composition and technology for psoriasis, applied in the field of medicine, can solve the problems of large toxic and side effects of chemical drugs, allergic symptoms of surrounding skin, unfavorable treatment of psoriasis, etc., and achieve the effects of no toxic and side effects, simple and unique formula, and synergistic therapeutic effect.

Inactive Publication Date: 2019-01-11
JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Judging from the existing technology, there are many kinds of medicines for the treatment of psoriasis on the market, all of which have different degrees of therapeutic effect on psoriasis, but most of the chemical medicines have problems such as large toxic and side effects, long course of treatment, easy recurrence, and easy drug resistance. , while traditional Chinese medicine compound prescriptions are mostly large prescriptions with complex ingredients and weak curative effects.
In addition, due to the irritation of the drug and the long course of treatment, allergic symptoms often appear on the surrounding skin, forcing the phenomenon of drug withdrawal during treatment, which is not conducive to the treatment of psoriasis

Method used

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  • A pharmaceutical composition for treating psoriasis
  • A pharmaceutical composition for treating psoriasis

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1 The preparation of the pharmaceutical composition for the treatment of psoriasis according to the present invention

[0023] External ointment 1: take 80% fig and 20% psoralen medicinal materials, coarsely crush the above two medicinal materials, add 10 times the amount of 70% ethanol for reflux extraction; filter the obtained extract, concentrate the filtrate and pass it through D101 macroporous resin Adsorption, 5 column volumes were eluted with distilled water, and then 5 column volumes were eluted with 80% ethanol; the eluent was recovered under reduced pressure, dried under reduced pressure and ground into powder. Weigh 98% of the drug powder in the mass percentage of the pharmaceutical composition to make a paste, add 2% hydrocortisone in the mass percentage of the pharmaceutical composition and mix evenly to obtain the product.

[0024] External ointment 2: take 50% fig and 50% psoralen medicinal materials, coarsely crush the above two medicinal mate...

Embodiment 2

[0027] Embodiment 2 The drug effect research of psoriasis pharmaceutical composition of the present invention to psoriasis model mice

[0028] 1. Experimental drugs and experimental animals:

[0029] Sample Example 1 of the present invention 1 external ointment 1, crude extract external ointment 1, external ointment 1 without antiallergic drug combination, psoriasis ointment (Hua Yao Tang); Kunming mice.

[0030] 2. Sample preparation:

[0031] Preparation of crude extract topical ointment 1: Take 80% fig and 20% psoralen medicinal material, coarsely pulverize the above two medicinal materials, add 10 times the amount of 70% ethanol for reflux extraction; filter the obtained extract, and concentrate the filtrate Dry and grind into powder. Weigh 98% of the drug powder in the mass percentage of the pharmaceutical composition to make a paste, add 2% hydrocortisone in the mass percentage of the pharmaceutical composition and mix evenly to obtain the product.

[0032] Preparatio...

Embodiment 3

[0040] Embodiment 3 The clinical pharmacodynamics research of the pharmaceutical composition for the treatment of psoriasis according to the present invention

[0041] 1. Clinical symptoms

[0042] Psoriasis vulgaris (red papules on the skin of the scalp, limbs, and trunk, with silvery white phosphorous scales on the surface, appearing as stars all over the body, and itching), erythrodermic psoriasis (diffuse red to dark red infiltrating lesions on the skin all over the body, There are a lot of dandruff on the surface, itching), pustular psoriasis (pustules spread out, often accompanied by high fever, joint swelling and pain, skin itching), arthropathic psoriasis (wrists, fingers and small joints such as toes have redness and swelling, Pain, accompanied by swelling of the skin near the joint, limited movement, joint stiffness), etc.

[0043] 2. Application results

[0044] Sample of the present invention (external application ointment 1) and reference medicine psoriasis oint...

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Abstract

The invention relates to a pharmaceutical composition for treating psoriasis and a preparation method thereof, the composition comprising an anti-allergic drug and an effective part of a Chinese medicinal composition for removing psoriasis, wherein the content of the anti-allergic drug is 0.5%-2.0%, the effective fraction content of Chinese herbal prescription for removing psoriasis is 98%-99.5%.At that same time of treat psoriasis, the invention also effectively prevents and treats the allergy of the skin around the patient through the combination of an antiallergic drug and a psoriasis removing drug. It is a good curative effect, high cure rate, not easy to relapse treatment of psoriasis composition, effectively solve the patient's suffering.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to a pharmaceutical composition for treating psoriasis, and also relates to a preparation method of the medicine. Background technique [0002] Psoriasis, as a common chronic and easily relapsing inflammatory skin disease with characteristic skin lesions, has been seriously endangering the health of our people for many years and greatly affecting people's quality of life. Judging from the existing technology, there are many kinds of medicines for the treatment of psoriasis on the market, all of which have different degrees of therapeutic effect on psoriasis, but most of the chemical medicines have problems such as large toxic and side effects, long course of treatment, easy recurrence, and easy drug resistance. , while traditional Chinese medicine compound prescriptions are mostly large prescriptions with complex ingredients and weak curative effects. In addition, because the d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/60A61P17/06A61K31/573
CPCA61K31/573A61K36/487A61K36/60A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2236/55A61P17/06A61K2300/00
Inventor 舒积成黄慧莲彭财英刘建群杨明
Owner JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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