A temperature/ph dual response type triblock polymer and its preparation method and application

A dual-response, polymer technology, applied in the field of polymers, can solve the problems of low immobilized enzyme immobilization rate and recycling rate, low response sensitivity, and limited functional monomers, etc., to achieve significant response effect, high sensitivity, high The effect of recovery

Active Publication Date: 2022-07-22
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, the temperature-responsive polymer can only respond to a single temperature, and has the disadvantages of limited functional monomers, low response sensitivity, and poor response effect. It is used for the immobilization of enzymes, which will lead to the immobilization rate of immobilized enzymes. And the problem of low recycling rate, it is difficult to meet the needs of practical applications

Method used

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  • A temperature/ph dual response type triblock polymer and its preparation method and application
  • A temperature/ph dual response type triblock polymer and its preparation method and application
  • A temperature/ph dual response type triblock polymer and its preparation method and application

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Embodiment 1

[0039] figure 1 It is the temperature / pH dual response type triblock polymer PEG according to the present invention 45 -b-PAAm 176 -b-P(GMA 21 -co-AAc 140 ), wherein a is a schematic diagram of the synthesis process of RAFT reagent (CTA), b is a schematic diagram of the synthesis process of a macromolecular chain transfer agent based on polyethylene glycol monomethyl ether, and c is polyethylene glycol-b-poly( Glycidyl methacrylate-co-acrylic acid) two-block polymer PEG 45 -b-P(GMA 21 -co-AAc 140 ) schematic diagram of the synthesis process, d is the temperature / pH dual-responsive triblock polymer PEG 45 -b-PAAm 176 -b-P(GMA 21 -co-AAc 140 ) schematic diagram of the synthesis process, and the specific preparation method is shown below.

[0040] (1) Preparation of RAFT reagent (CTA):

[0041] After dissolving 3.25g potassium hydroxide KOH in 32mL deionized water, add 2.5mL 3-mercaptopropionic acid C dropwise 3 H 6 O 2 S, followed by dropwise addition of 4 mL of ca...

Embodiment 2

[0051] The preparation process in steps (1) to (2) is the same as that in Example 1.

[0052] (3) Polyethylene glycol-b-poly(glycidyl methacrylate-co-acrylic acid) two-block polymer PEG 45 -b-P(GMA 21 -co-AAc 140 ) preparation:

[0053] 0.47g PEG 45 - CTA, acrylic acid (AAc, 1.38 g, 20 mmol), 1 mmol glycidyl methacrylate (GMA) and 0.0146 g initiator azobisisobutyronitrile (AIBN) dissolved in 10 mL of 1,4-dioxane , transferred to a single-necked round-bottomed flask with a magnet, bubbled with nitrogen for 30 min to remove the oxygen in the reaction solution, and sealed under a nitrogen atmosphere. Then the flask was placed in an oil bath at 75°C and stirred for 24 hours. After the reaction was completed, the reaction was quenched with an ice-water bath, diluted with 1,4-dioxane and added to excess anhydrous ether for precipitation. The product was redissolved in 1,4-dioxane, and the product was precipitated with anhydrous ether. After repeating the dissolution-precipitati...

Embodiment 3

[0060] The preparation process in steps (1) to (2) is the same as that in Example 1.

[0061] (3) Polyethylene glycol-b-poly(glycidyl methacrylate-co-acrylic acid) two-block polymer PEG 45 -b-P(GMA 21 -co-AAc 140 ) preparation:

[0062] 0.48g PEG 45 -CTA, acrylic acid (AAc, 1.41 g, 20 mmol), 1 mmol glycidyl methacrylate (GMA) and 0.0148 g initiator azobisisobutyronitrile (AIBN) dissolved in 11 mL of 1,4-dioxane , transferred to a single-necked round-bottomed flask with a magnet, bubbled with nitrogen for 30 min to remove the oxygen in the reaction solution, and sealed under a nitrogen atmosphere. Then the flask was placed in an oil bath at 78 °C to stir the reaction for 24 h. After the reaction was completed, the reaction was quenched with an ice-water bath, diluted with 1,4-dioxane and added to excess anhydrous ether for precipitation. The product was redissolved in 1,4-dioxane, and the product was precipitated with anhydrous ether. After repeating the dissolution-precip...

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Abstract

The invention belongs to the technical field of polymers, and relates to a temperature / pH dual-responsive triblock polymer and a preparation method and application thereof. The polymer consists of a water-soluble PEG block and a thermosensitive AAm block, a pH-responsive AAc block and a hydrophobic GMA block. The temperature / pH dual-responsive triblock polymer is prepared by first preparing a trithioester containing a carboxyl group, and then performing an esterification reaction with polyethylene glycol monomethyl ether to prepare a polyethylene glycol macromolecular chain transfer. A temperature / pH dual-responsive block polymer PEG-b-PAAm-b-P (GMA-co-AAc) was prepared by RAFT polymerization. The purpose of the present invention is to provide a dual stimuli-responsive polymer obtained by integrating two different stimuli-responsive units on one polymer molecular chain, which can respond to two stimuli in the environment and has a more "intelligent performance" change".

Description

technical field [0001] The invention belongs to the technical field of polymers, and in particular relates to a temperature / pH dual-responsive triblock polymer and a preparation method and application thereof. Background technique [0002] Stimuli-responsive polymers are a class of macromolecular materials that can accept stimuli from external factors to change their structure and properties (such as molecular chain structure, solubility, charged state, and polymer chain interactions, etc.). Common stimuli-responsive polymers mainly include temperature-responsive polymers, pH-responsive polymers, light-responsive polymers, redox-responsive polymers, and polymers that respond to other factors. After the temperature-responsive polymer feels the external temperature stimulus, the polymer chains will aggregate with each other in the aqueous solution, and macroscopically, it appears as a high-molecular polymer precipitated from the aqueous solution. Due to the easy realization o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F293/00C07D487/22
CPCC08F293/005C07D487/22C08F2438/03
Inventor 顾林彦王蕾兰会玲韩娟王赟刘园园刘怡涵
Owner JIANGSU UNIV
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