Temperature/pH dual response type triblock polymer as well as preparation method and application thereof

A dual-response, polymer technology, applied in the field of polymers, can solve the problems of low immobilization rate and recycling rate of immobilized enzymes, low response sensitivity, limited functional monomers, etc., to achieve significant response effect, high sensitivity, high The effect of recovery

Active Publication Date: 2021-12-07
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the temperature-responsive polymer can only respond to a single temperature, and has the disadvantages of limited functional monomers, low response sensitivity, and poor response effect. It is used for the immobilization of enzymes, which will lead to the immobilization rate of immobilized enzymes. And the problem of low recycling rate, it is difficult to meet the needs of practical applications

Method used

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  • Temperature/pH dual response type triblock polymer as well as preparation method and application thereof
  • Temperature/pH dual response type triblock polymer as well as preparation method and application thereof
  • Temperature/pH dual response type triblock polymer as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] figure 1 The temperature / pH dual response type triblock polymer PEG described in the present invention 45 -b-PAAm 176 -b-P(GMA 21 -co-AAc 140 ), wherein a is the synthetic process schematic diagram of RAFT reagent (CTA), b is the synthetic process schematic diagram of the macromolecular chain transfer agent based on polyethylene glycol monomethyl ether, and c is polyethylene glycol-b-poly( Glycidyl methacrylate-co-acrylic acid) diblock polymer PEG 45 -b-P(GMA 21 -co-AAc 140 ) is a schematic diagram of the synthesis process, and d is a temperature / pH dual-responsive triblock polymer PEG 45 -b-PAAm 176 -b-P(GMA 21 -co-AAc 140 ) Schematic diagram of the synthesis process, and the specific preparation method is as follows.

[0040] (1) Preparation of RAFT reagent (CTA):

[0041] After dissolving 3.25g of potassium hydroxide KOH in 32mL of deionized water, add 2.5mL of 3-mercaptopropionic acid C 3 h 6 o 2 S, then add 4 mL of carbon disulfide CS dropwise under v...

Embodiment 2

[0051] The preparation process in steps (1)-(2) is the same as that in Example 1.

[0052] (3) Polyethylene glycol-b-poly(glycidyl methacrylate-co-acrylic acid) diblock polymer PEG 45 -b-P(GMA 21 -co-AAc 140 ) preparation:

[0053] 0.47g PEG 45 - CTA, acrylic acid (AAc, 1.38 g, 20 mmol), 1 mmol glycidyl methacrylate (GMA) and 0.0146 g initiator azobisisobutyronitrile (AIBN) were dissolved in 10 mL of 1,4-dioxane , transferred to a single-necked round-bottomed flask with a magnet, nitrogen bubbling for 30 min to remove oxygen in the reaction solution, and sealed under a nitrogen atmosphere. Then place the flask in an oil bath at 75°C and stir for 24 hours. After the reaction, the reaction is quenched with an ice-water bath, diluted with 1,4-dioxane and added to excess anhydrous ether for precipitation. The resulting The product was re-dissolved in 1,4-dioxane, and the product was precipitated with anhydrous ether. After the dissolution-precipitation was repeated three time...

Embodiment 3

[0060] The preparation process in steps (1)-(2) is the same as that in Example 1.

[0061] (3) Polyethylene glycol-b-poly(glycidyl methacrylate-co-acrylic acid) diblock polymer PEG 45 -b-P(GMA 21 -co-AAc 140 ) preparation:

[0062] 0.48g PEG 45 - CTA, acrylic acid (AAc, 1.41 g, 20 mmol), 1 mmol glycidyl methacrylate (GMA) and 0.0148 g initiator azobisisobutyronitrile (AIBN) were dissolved in 11 mL of 1,4-dioxane , transferred to a single-necked round-bottomed flask with a magnet, nitrogen bubbling for 30 min to remove oxygen in the reaction solution, and sealed under a nitrogen atmosphere. Then place the flask in an oil bath at 78°C and stir for 24 hours. After the reaction, the reaction is quenched with an ice-water bath, diluted with 1,4-dioxane and added to excess anhydrous ether for precipitation. The resulting The product was re-dissolved in 1,4-dioxane, and the product was precipitated with anhydrous ether. After the dissolution-precipitation was repeated three time...

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Abstract

The invention belongs to the technical field of polymers, and relates to a temperature/pH dual response type triblock polymer as well as a preparation method and application thereof. The polymer consists of a water-soluble PEG (Polyethylene Glycol) block, a thermo-sensitive AAm block, an AAc block with pH (Potential of Hydrogen) response and a hydrophobic GMA (Glycidyl Methacrylate) block. The temperature/pH dual response type triblock polymer is prepared by the following steps: firstly, preparing carboxyl-containing trithioester, then carrying out esterification reaction on the carboxyl-containing trithioester and methoxypolyethylene glycol to prepare a polyethylene glycol macromolecular chain transfer agent, and preparing the temperature/pH dual response type block polymer PEG-b-PAAm-b-P (GMA-co-AAc) by adopting an RAFT (Reversible Addition-Fragmentation Chain Transfer) polymerization method. The invention aims to provide a dual-stimulus response type polymer which is obtained by integrating two different stimulus response units on one polymer molecular chain, can respond to two stimulus factors in the environment, and is more intelligent in performance.

Description

technical field [0001] The invention belongs to the technical field of polymers, and in particular relates to a temperature / pH dual-responsive tri-block polymer and its preparation method and application. Background technique [0002] Stimuli-responsive polymers are a class of polymer materials that can be stimulated by external factors to change their own structure and properties (such as molecular chain structure, solubility, charged state, and polymer chain interaction, etc.). Common stimuli-responsive polymers mainly include temperature-responsive polymers, pH-responsive polymers, light-responsive polymers, redox-responsive polymers, and other responsive factor polymers. After the temperature-responsive polymer is stimulated by the external temperature, the polymer chains will aggregate in the aqueous solution, and macroscopically appear as a high molecular polymer precipitated from the aqueous solution. Due to the easy realization of temperature changes, temperature-re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F293/00C07D487/22
CPCC08F293/005C07D487/22C08F2438/03
Inventor 顾林彦王蕾兰会玲韩娟王赟刘园园刘怡涵
Owner JIANGSU UNIV
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