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Application of CST polypeptide in preparation of medicine for treating femoral head necrosis

A technology for femoral head necrosis and treatment drugs, which is applied in the medical field and can solve problems such as limited curative effect

Pending Publication Date: 2021-12-17
SHANDONG UNIV QILU HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, the current use of related drugs has limited curative effect, and long-term use has certain side effects, so the use is limited to a certain extent.

Method used

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  • Application of CST polypeptide in preparation of medicine for treating femoral head necrosis
  • Application of CST polypeptide in preparation of medicine for treating femoral head necrosis
  • Application of CST polypeptide in preparation of medicine for treating femoral head necrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0027] Sources of experimental animals, reagents, culture media and buffers involved in the following examples:

[0028] Cortistatin (Cortistatin, molecular weight: 1720.03) (Gill Biochemical Co., Ltd.).

[0029] SD male rats, (Shandong University Animal Center)

[0030] PBS buffer, (Beiyuntian Biological Reagent Company)

[0031] Col2 antibody, MMP13 antibody, ADAMTS-5 antibody (Thermo Fisher, Pierce)

[0032] RIPA cell protein extraction lysate (Thermo Fisher, Pierce)

[0033] Protease Inhibitors (Beijing Solaibao Technology Co., Ltd.)

[0034] BCA protein quantification kit (Shanghai Yanxi Biotechnology Co., Ltd.)

[0035] Complete EDTA-Free (Roche Biopharmaceuticals)

[0036] Xylene (Sinopharm Chemical Reagent Co., Ltd.)

[0037] Neutral gum (Shanghai Titan Technology Co., Ltd.)

[0038] Concentrated hydrochloric acid (Sinopharm Chemical Reagent Co., Ltd.)

[0039] Yihong (Shanghai Titan Technology Co., Ltd.)

[0040] Hematoxylin (Shanghai Titan Technology Co., Lt...

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Abstract

The invention discloses application of CST polypeptide in preparation of a medicine for treating femoral head necrosis, particularly application in preparation of a medicine for treating hormone-induced femoral head necrosis, and particularly application in preparation of a medicine for relieving hormone-induced femoral head necrosis collapse. The functional polypeptide CST plays a protective role in femoral head necrosis. In-vitro cell experiments show that CST can antagonize an osteoblast apoptosis process caused by glucocorticoid. Meanwhile, an animal model shows that CST can inhibit femoral head necrosis collapse and improve the illness state, has no obvious toxic or side effect after long-term application, can be used in the fields of femoral head necrosis and the like, and has wide application value and market prospect.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of CST polypeptide in the preparation of drugs for the treatment of femoral head necrosis. Background technique [0002] At present, necrosis of the femoral head is more common clinically, and it tends to be younger at present. According to statistics, in my country alone, there are more than 5 million patients with femoral head necrosis. At present, there is no specific drug for osteonecrosis of the femoral head, and the clinically applied drugs are not effective. If the patient's condition is severe, hip joint surgery, heart medullary decompression or hip joint replacement surgery is required[1]. However, the surgery itself has associated risks and complications, and has its own limiting factors. With the increasing number of patients, the treatment of femoral head necrosis has caused a huge burden on society and families. [0003] At present, most of the therapeutic ...

Claims

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Application Information

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IPC IPC(8): A61K38/10A61P19/08
CPCA61K38/10A61P19/08
Inventor 赵云鹏李魏玮李玉华陈永坤夏燕妮张鹏飞张帅王霞
Owner SHANDONG UNIV QILU HOSPITAL
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