Intestinal juice collecting device, intestinal juice capsule preparation method and intestinal juice capsule
A collection device and capsule preparation technology, which is applied in the field of microbiology, can solve the problems of small amount of viable bacteria in small intestinal fluid, low proportion of viable bacteria, cumbersome collection steps, etc., achieve the effect of reducing macromolecular substances, reducing processing steps, and improving drainage efficiency
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Embodiment 1
[0062] This embodiment relates to the small intestinal fluid collection device of the present invention.
[0063] Such as figure 1 As shown, a small intestinal fluid collection device includes a collection unit 100, a negative pressure unit 200 and a catheter unit 300, wherein one end of the collection unit 100 is placed in the distal jejunum of the human body, and the negative pressure unit 200 is directly connected to the collection unit 100 or The catheter unit 300 is connected to the collection unit 100 , wherein the collection unit 100 sucks the small intestinal fluid of the jejunum under the negative pressure provided by the negative pressure unit 200 , and the negative pressure unit 200 filters the small intestinal fluid.
[0064] Such as Figure 2~4 As shown, the collection unit 100 includes a first tube 101, a second tube 102, several through holes 103, and a cover element 104, wherein the first tube 101 is used to suck the jejunum under the negative pressure provide...
Embodiment 2
[0108] This embodiment relates to the preparation method of the small intestine juice capsule and the small intestine juice capsule of the present invention.
[0109] A method for preparing small intestine liquid capsules, comprising the following steps:
[0110] Step S402, using the small intestinal fluid collection device in Example 1 to collect small intestinal fluid;
[0111] Step S404, adding glycerin to the small intestinal fluid to form the small intestinal fluid to be treated;
[0112] Step S406, prefreezing the small intestinal fluid to be treated at -4°C to form frozen small intestinal fluid;
[0113] Step S408, freeze-drying the frozen small intestinal fluid to obtain small intestinal fluid bacterial powder;
[0114] Step S410, using the capsule shell to include the small intestine juice bacteria powder to form a small intestine juice capsule.
[0115] Wherein, in step S408, the water content of the bacteria powder of small intestine juice is lower than 5%. The ...
Embodiment 3
[0136] This example is a specific application example of the preparation method of Xiaochangye capsules.
[0137] The various parameters of small intestine juice and small intestine juice bacterial powder prepared by the small intestine juice capsule preparation method of embodiment 2 are shown in the following table:
[0138] sample sample type Total number of colonies (unit / mL) Total number of colonies (pcs / g) Live bacteria ratio sample 1 Intestinal fluid 6.03×10 8
- 85.89％ sample 2 Intestinal fluid 5.70×10 8
- 89.47％ sample 3 Intestinal fluid 1.12×10 9
- 83.93％ Sample 4 Intestinal fluid 5.73×10 8
- 83.21％ Sample 5 Intestinal fluid 5.93×10 8
- 86.92％ Sample 6 Intestinal fluid 6.50×10 8
- 83.31％ Sample 7 Small Intestinal Liquid Bacteria Powder - 7.70×10 6
82.05％ Sample 8 Small Intestinal Liquid Bacteria Powder - 2.11×10 6
83.88％
[0139] Among them, the...
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