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Functional recovery from cerebral infarction

A technology of cerebral infarction and cell population, applied in the direction of medical preparations containing active ingredients, bone/connective tissue cells, drug combinations, etc., can solve problems such as cerebral infarction that has not been approved, and achieve the effect of reducing the risk of cerebral infarction

Pending Publication Date: 2021-12-28
MESOBLAST INT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] There are no approved treatments for cerebral infarction other than tissue plasminogen activator (TPA) if administered within three hours of onset of symptoms

Method used

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  • Functional recovery from cerebral infarction
  • Functional recovery from cerebral infarction
  • Functional recovery from cerebral infarction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0149] Example 1: Treatment with human MPCs improves motor function in a rodent model of infarction.

[0150] Animals, Habitation and Diet

[0151] Eighty-four male nude mice (RNU mice, Taconic, IBU051001C) of 250 g to 275 g arrived 7-10 days before surgery. They were allowed free access to food and water throughout the study. Animals are assigned consecutive identification numbers using a permanent marker on the tail. The animals were observed the day before surgery and those that appeared to be in poor health were excluded from the study.

[0152] Animals were housed in an air-filtered room with a temperature of 21 ± 2°C and a relative humidity of 50% ± 20%. There is an automatic timer in the room with a light / dark cycle of 12 hours on, 12 hours off, no shimmer. 1 / 4" good quality corn cob for bedding, 1 in each cage (3.5”, Dura bones Petite). Animals were fed Lab 5001 food. Water is provided ad libitum.

[0153] Two animals were housed in each cage before and af...

Embodiment 2

[0180] Example 2: Effect of Intravenous Injection of hMPC or Vehicle on Functional Imaging of a Rat Cerebral Infarction Model

[0181] Infarction model

[0182] Use the animals in the induction chamber for N 2 O:O 2 Anesthetized in 2-3% isoflurane in (2:1) and maintained with 1-1.5% isoflurane by face mask. Once anesthetized, animals received cefazolin sodium (40 mg / kg, i.p.) and buprenorphine (0.1 mg / kg, s.c.). Apply veterinary ophthalmic ointment Lacrilube to the eyes to prevent eye dryness. During the operation, all animals were maintained at 37.0±1°C. In all animals, a small focal stroke (infarct) was created on the right side of the brain surface (cerebral cortex) by middle cerebral artery occlusion (MCAO). Using an aseptic procedure, an incision is made between the eye and the eardrum tube. The temporalis muscle is separated, bisected and visualized.

[0183]A small piece of bone was removed via a burr hole and rongeurs (infratemporal craniectomy), exposing the ...

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Abstract

The present disclosure provides methods of treating a subject who has suffered a cerebral infarction, the method comprising administering systemically to the subject a population of cells enriched for mesenchymal lineage precursor or stem cells (MLPSCs) such as STRO-1+ cells or progeny thereof to increase stimulus-induced cortical activation or reduce infarct volume.

Description

technical field [0001] The present disclosure relates to methods of treating cerebral infarction in a human subject. Background technique [0002] Cerebral infarction remains the leading cause of morbidity and mortality in the industrialized world. Cerebral infarction is the third leading cause of death. Cerebral infarction is the rapid loss of one or more brain functions due to impaired blood supply to the brain. There are two common types of cerebral infarction: (i) ischemic cerebral infarction, which is caused by temporary or permanent blockage of blood flow to the brain and accounts for 85% of cerebral infarction cases, and (ii) hemorrhagic cerebral infarction, which is caused by vascular rupture, which accounts for the majority of remaining cases. Cerebral infarction often results in neuronal cell death and can lead to death. The most common cause of ischemic cerebral infarction is occlusion of the middle cerebral artery (the intracranial artery downstream of the in...

Claims

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Application Information

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IPC IPC(8): A61K35/28A61K35/545A61K45/06A61K31/047A61K31/4188A61P25/00A61P9/10
CPCA61K35/28A61P9/10C12N5/0662A61K31/495A61K31/047
Inventor S·伊茨库
Owner MESOBLAST INT