Synthesis method of indole derivative
A technology of indole derivatives and synthesis methods, applied in chemical instruments and methods, chemical/physical processes, physical/chemical process catalysts, etc., can solve the problems of complex structure, high price and harsh conditions of main catalysts
Pending Publication Date: 2021-12-31
TAIYUAN UNIV OF TECH +2
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[0005] The present invention provides a synthesis method of indole derivatives in order to solve the problems of relatively harsh conditions, complicated structure and high price of the main catalyst in the current reaction of synthesizing indole and its derivatives with ethylene glycol as raw material
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[0036] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are part of the embodiments of the present invention, rather than All the embodiments; based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts all belong to the protection scope of the present invention.
[0037] 1. Experimental reagents and instruments: See Table 1 for experimental instruments and Table 2 for reagents.
[0038] Table 1: Experimental Instruments
[0039]
[0040] Table 2: Experimental Reagents
[0041]
[0042]
[0043]
[0044] 2. Synthesis of Indole Derivatives
[0045] 1. Experimental method:
[0046]Preparation of supported catalysts: first acid-supported Al 2 o 3 Placed...
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Abstract
The invention belongs to the technical field of indole synthesis, and provides a synthesis method of an indole derivative in order to solve the problems of relatively harsh reaction conditions, complex structure and high price of a main catalyst, and the like in synthesis of indole and derivatives thereof by taking ethylene glycol as a raw material at present. The method comprises the following steps: preparing a Pt-loaded Pt / Al2O3 catalyst by taking acidic Al2O3 as a carrier and using an impregnation method; carrying out a catalytic reaction on an aniline compound, ethylene glycol and the prepared Pt / Al2O3 catalyst, controlling the reaction temperature to be 190 DEG C, and reacting for 24 hours; and after the reaction is finished, firstly adding water and stirring well, then extracting by using dichloromethane, carrying out rotary evaporation concentration on an organic phase to remove a solvent, and then carrying out column chromatography separation by taking petroleum ether and ethyl acetate as eluents to obtain a target product. A catalytic system of a Pt / Al2O3 supported catalyst with a good catalytic effect in ethylene glycol aniline reaction is subjected to broad-spectrum research, and the substrate range of substituted aniline is mainly expanded.
Description
technical field [0001] The invention belongs to the technical field of indole synthesis, and in particular relates to a synthesis method of indole derivatives. Background technique [0002] Indole, also known as benzopyrrole, consists of a benzene ring and a pyrrole ring. Indole and its derivatives are widely found in various organisms and were originally discovered by the degradation of indigo. Coal tar, spices, amino acids, and hormones all contain indole and indole derivatives, and the odor of feces has a lot to do with the 3-methylindole contained therein. In addition, indole and its derivatives, as very important intermediates or characteristic structures, are widely used in the field of medicine. [0003] The catalytic systems in the existing methods for synthesizing indole and its derivatives are all multi-component catalysis, and the main catalysts are noble metals with complex structures and expensive prices. The one-step catalytic synthesis of indole and its der...
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IPC IPC(8): C07D209/60C07D209/08B01J23/42
CPCC07D209/60C07D209/08B01J23/42B01J35/23Y02P20/584
Inventor 常宏宏延秀银李学金张娟高文超任凡闫庆芳
Owner TAIYUAN UNIV OF TECH