35 results about "Benzopyrrole" patented technology

Disclosed are compounds of formulae I and II, and pharmaceutically acceptable salts and prodrugs thereof, which are inhibitors of the complement system. Also provided are pharmaceutical compositions comprising such a compound, and methods of using the compounds and compositions in the treatment or prevention of a disease or condition characterized by aberrant complement system activity.

The application discloses a kind of side group containing halogen diphenol compound and its preparation method and application.The preparation method includes the following steps: step 1, phenothiazine and aromatic primary amine derivative hydrochloride are dissolved in aromatic primary amine derivative, ammonolysis reaction, quenching separation, obtain halogen-containing 2-aryl-3,3-bis (hydroxyaryl) benzopyrrolone derivative crude product;Step 2, the halogen-containing 2-aryl-3,3-bis (hydroxyaryl) benzopyrrolone derivative crude product is purified to obtain the halogen-containing 2-aryl-3,3-bis (hydroxyaryl) benzopyrrolone derivative.The halogen-containing 2-aryl-3,3-bis (hydroxyaryl) benzopyrrolone derivative obtained by the above preparation method is higher than 60%, the purity after purification is higher than 98%, raw material is easy to obtain, process is simple, and it is suitable for industrial production.