6-flourine-3a-(trifluoromethyl)-2,3,3a,4-tetrahydro-1h-benzo[d]pyrrole[1,2-a]imidazole-1-ketone and method for synthesizing same

Abstract

The invention relates to a 6-flourine-3a-(trifluoromethyl)-2,3,3a,4-tetrahydro-1H-benzo[d]pyrrole[1,2-a]imidazole-1-ketone and a method for synthesizing the same. The structural formula of the compound is shown as a right formula. The method comprises the following steps that: trifluoro gamma-keto acid methyl ester and toluene sulfonic acid are dissolved in toluene and added with anhydrous magnesium sulfate in catalyst amount, and the mixture is subjected to refluxing reaction for 20 to 60 minutes in stirring, and then added with fluorine o-phenylendiamine; the mixture is continuously reacted for 10 to 15 hours and then added with toluene sulfonic acid in catalyst amount; the mixture is subjected to refluxing reaction for 10 to 15 hours; after the reaction, the mixture is separated and purified to obtain a white solid which is the 6-flourine-3a-(trifluoromethyl)-2,3,3a,4-tetrahydro-1H-benzo[d]pyrrole[1,2-a]imidazole-1-ketone; and the molar ratio of the trifluoro gamma-keto acid methyl ester to the fluorine o-phenylendiamine is 1-1.2:1. The 6-flourine-3a-(trifluoromethyl)-2,3,3a,4-tetrahydro-1H-benzo[d]pyrrole[1,2-a]imidazole-1-ketone has stronger activity and is absorbed more easily. Moreover, the method has the advantages of easily bought raw materials, quite simple operation, synthesis by a one-pot method, 58 percent of yield and suitability for mass production.

Description

Technical field:

[0001] The present invention relates to a 3'-trifluoromethyl-1-fluorobenzimidazole pyrrolone derivative and its synthesis method, especially a 6-fluoro-3a-(trifluoromethyl)-2,3, 3a,4-Tetrahydro-1H-benzo[d]pyrrole[1,2-a]imidazol-1-one and its synthesis method. Background technique:

[0002] Nitrogen-containing heterocyclic compounds are widely used not only in pesticides but also in medicine, so they are a very important class of organic compounds. In recent decades, scientists have continuously explored its new synthesis process, and conducted a lot of research on its structure and properties.

[0003] As an important nitrogen-containing heterocyclic compound, benzimidazoles have been widely used and studied in recent years. Not only can it be used as a drug with low toxicity and high efficiency, but its polymer can also be used as a high temperature resistant composite material. Pyrrolidone compounds are also a class of compounds with high application va...

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