Chicoric acid inhalation aerosol as well as preparation method and application thereof
A technology of cichoric acid and aerosol, which is applied in the direction of pharmaceutical formulations, antiviral agents, medical preparations of non-active ingredients, etc., can solve the problems of being easily oxidized when exposed to light, unstable structure, and low bioavailability, and achieve Avoid the first-pass effect, easy to carry, and high local concentration
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
preparation example Construction
[0042] In another specific embodiment of the present invention, the preparation method of the above-mentioned cichoric acid inhalation aerosol is provided, and the preparation method comprises:
[0043] 1) Add the cichoric acid of the prescribed amount to 30-50% (w / w) absolute ethanol and stir to dissolve;
[0044] 2) Add the prescribed amount of propylene glycol, rinse the container of the stabilizer with the remaining absolute ethanol, add the rinse solution, and stir the materials until they are evenly mixed to obtain a clear and transparent medicinal solution;
[0045] 3) Put the liquid medicine into the pressure-resistant container for filling, insert the valve, seal, and fill the hydrofluoroalkane propellant.
[0046] In the step 3), the pressure-resistant container can be an aluminum can; further, before use, the air in the aluminum can is exhausted by vacuuming or filling with nitrogen, and it is set aside.
[0047] In yet another specific embodiment of the present inve...
Embodiment 1～6
[0055] Chichoric Acid Inhalation Aerosol:
[0056] The added amount of the active ingredient is 0-0.5% (0-3mg), the added amount of absolute ethanol is 5.67% (0.6g), and the added amount of tetrafluoroethane is 94.33% (10g). See Table 1 below for details:
[0057] Table 1. The prescription of embodiment 1~6
[0058]
[0059] Preparation method: add the prescribed amount of active ingredients into an appropriate amount of absolute ethanol, fully dissolve, make up the remaining absolute ethanol, mix well until the solution is clear and transparent, add it into a pressure-resistant container; insert the valve into the pressure-resistant container, seal it, and pour Install propellant, that is. After filling, weigh them one by one and remove unqualified samples.
[0060] Experimental results
[0061] The prepared aerosol sample was placed in a refrigerator (4° C.), and the stability of the preparation of the sample within 48 hours was investigated by a clarity tester. The r...
Embodiment 7～11
[0065] Chichoric Acid Inhalation Aerosol:
[0066] The added amount of the active ingredient is 0.02%, the added amount of absolute ethanol is 1.96%-10.71%g, and the added amount of the propellant is 89.27%-98.02%. See Table 3 below for details:
[0067] Table 3. The prescription of embodiment 7~11
[0068] Example Chichoric acid The amount of absolute ethanol amount of propellant 7 0.02％ 1.96％ 98.02％ 8 0.02％ 3.85％ 96.13％ 9 0.02％ 5.66％ 94.32％ 10 0.02％ 9.09％ 90.89％ 11 0.02％ 10.71％ 89.27％
[0069] Preparation method: add the prescribed amount of active ingredients into an appropriate amount of absolute ethanol, fully dissolve, make up the remaining absolute ethanol, mix well until the solution is clear and transparent, add it into a pressure-resistant container; insert the valve into the pressure-resistant container, seal it, and pour Install propellant, that is. After filling, weigh them one by one and remove unqualified...
PUM
Login to View More Abstract
Description
Claims
Application Information
Login to View More