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Polyethyleneimine modified quantum dot nanoparticle, preparation method thereof and application of polyethyleneimine modified quantum dot nanoparticle as nano-drug carrie

A nano-drug carrier, polyethyleneimine technology, applied in the field of chemical biology, can solve the problems of dose toxicity limitation, poor solubility, etc., and achieve the effects of simple and easy preparation method, low cost and good optical characteristics

Pending Publication Date: 2022-01-11
HENAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the poor solubility and dosage toxicity of these drugs in water greatly limit their clinical application, but nano drug delivery system can well solve these problems

Method used

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  • Polyethyleneimine modified quantum dot nanoparticle, preparation method thereof and application of polyethyleneimine modified quantum dot nanoparticle as nano-drug carrie
  • Polyethyleneimine modified quantum dot nanoparticle, preparation method thereof and application of polyethyleneimine modified quantum dot nanoparticle as nano-drug carrie
  • Polyethyleneimine modified quantum dot nanoparticle, preparation method thereof and application of polyethyleneimine modified quantum dot nanoparticle as nano-drug carrie

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] When the quantum dot 2 is CdSe, the synthesis steps for preparing the polyethyleneimine-modified quantum dot nano drug carrier are as follows:

[0036] .

[0037] 1) Preparation of compound 3: Add 0.20 g of polyethyleneimine 1 (PEI, 1.8 kDa)) into 10 mL of chloroform in a 100 mL round bottom flask, and dissolve completely by ultrasonication. Then add quantum dots 2 (CdSe, 10.0 mg) into the flask. 0.2 mL of ammonia water was added to adjust the pH to 10, the resulting solution was stirred at room temperature (25°C) for 12 h, and the chloroform in the mixture was removed by rotary evaporation. Re-dissolved with ethanol and centrifuged for further purification. This operation was repeated three times, and then vacuum-dried to obtain polyethyleneimine-modified quantum dot nanoparticles 3 (CdSe@PEI).

[0038] 2) Preparation of compound 5: Add a mixture of 104.3 mg of compound 4 10-hydroxycamptothecin (cHCPT, 0.29 mmol), 35.0 mg (0.29 mmol) of 4-dimethylaminopyridine and ...

Embodiment 2

[0044] When the quantum dot 2 is CdSe / ZnSe, the synthesis steps for preparing polyethyleneimine-modified quantum dot nano drug carrier are as follows:

[0045] .

[0046] 1) Preparation of compound 3: Add 0.20 g of polyethyleneimine 1 (PEI, 1.8 kDa)) into 10 mL of chloroform in a 100 mL round-bottom flask, and dissolve completely by ultrasonication. Then add quantum dots 2 (CdSe / ZnS, 10.0 mg) into the flask. 0.2 mL of ammonia water was added to adjust the pH to 10, and the resulting solution was stirred at room temperature for 12 h. The chloroform in the mixture was removed by rotary evaporation. Re-dissolved with ethanol and centrifuged for further purification. This operation was repeated three times, and then vacuum-dried to obtain polyethyleneimine-modified quantum dot nanoparticles 3 (CdSe / ZnS@PEI).

[0047] 2) Preparation of Compound 5: Refer to Example 1.

[0048] 3) Preparation of product 6: Dissolve 46.8 mg of compound 5 (cHCPT) in 5 mL of anhydrous dimethylsulf...

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Abstract

The invention belongs to the field of chemical biology, and particularly relates to a polyethyleneimine modified quantum dot particle, a preparation method thereof and an application of the polyethyleneimine modified quantum dot particle as a nano-drug carrier. The polyethyleneimine modified quantum dot nanoparticle drug carrier has a structure as shown in the following formula, in the formula, QDs refer to quantum dots CdSe or CdSe / ZnS. According to polyethyleneimine modified quantum dot nanoparticles, the particle size is small, the water solubility is, uniform dispersion is achieved, the stability is good, low cytotoxicity to various cells is achieved, so the polyethyleneimine modified quantum dot nanoparticles can be used as a good nano-drug carrier to be applied to the field of the chemical biology, and a foundation can be laid for better design of the nano-drug carrier.

Description

technical field [0001] The invention belongs to the technical field of chemical biology, and in particular relates to a polyethyleneimine-modified quantum dot nanoparticle, a preparation method thereof and an application as a nanometer drug carrier. Background technique [0002] Quantum dots (QDs) play an important role in monitoring and imaging cancer cells due to their unique photochemical properties. At the same time, due to their large specific surface area, QDs can be used as carriers of anticancer drugs to achieve drug delivery. Weng et al. designed and synthesized the targeting ligands conjugated hydrophilic QDs and PEG phospholipids, which were bound to the lipid membrane layer of liposomes during liposome hydration, loaded with anticancer drug doxorubicin, and obtained Targeted and traceable drug delivery carrier. Although the design is relatively simple, both external and internal QDs loading degrade the drug loading capacity and fluorescence intensity. Therefor...

Claims

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Application Information

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IPC IPC(8): A61K47/34A61K47/02A61K31/4745A61K9/51A61P35/00A61K49/00
CPCA61K47/34A61K47/02A61K31/4745A61K9/5146A61P35/00A61K49/0019A61K49/0054
Inventor 赵美霞任斌甘莹李景华张志强
Owner HENAN UNIVERSITY
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