Double-network hydrogel film with single-side hydrophobicity and preparation method thereof

A hydrogel, hydrophobic technology, applied in the direction of human tubular structure devices, prostheses, tissue regeneration, etc., can solve the problem of restricting cell growth in the exchange of nutrients and cell waste, controlling porosity, microstructure and pore connection difficulties and other problems, to achieve the effect of preventing bacterial infection, good toughness, and promoting tissue repair.

Active Publication Date: 2022-01-21
SOUTHEAST UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] In urology, the problem of urethral repair has always been one of the thorniest problems for clinical surgeons. Congenital deformities, inflammation, trauma or tumors and other diseases cause urethral damage, stenosis or defect, which needs to be repaired and reconstructed accordingly. With the development of medical level, alternative materials such as

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  • Double-network hydrogel film with single-side hydrophobicity and preparation method thereof
  • Double-network hydrogel film with single-side hydrophobicity and preparation method thereof
  • Double-network hydrogel film with single-side hydrophobicity and preparation method thereof

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Example Embodiment

[0033] A preparation method of a double-network hydrogel film with single-sided hydrophobicity according to the present invention comprises the following steps:

[0034] Step 1. Dissolve the polymer material polyvinyl alcohol (PVA) and the natural hydrogel material chitosan (CS) into a solution, respectively, including dissolving the PVA particles in deionized water, and heating them in a water bath at 90° C. for 1h and fully stirring In a solution state, the CS powder is dissolved in 0.2% acetic acid solution to form a 5% chitosan acetic acid solution, and the PVA solution and the CS acetic acid solution are fully mixed in a ratio of 4:1, 6:1, or 8:1.

[0035]Step 2, stir and mix 70% phytic acid solution and magnesium chloride hexahydrate in a ratio of 6:1, add the configured magnesium phytate solution to the mixed sol in step 1 at room temperature, and after mixing and stirring, adjust the pH with NaOH aqueous solution After reaching 6-8, statically drop the solution into th...

Example Embodiment

[0040] Example 1

[0041] (1) Dissolve 14g of PVA particles in 40ml of deionized water, and heat in a water bath at 90°C for 1.5h to fully magnetically stir into a solution state, dissolve 3.5g of CS powder in 10ml of 0.2% acetic acid solution, and add 40ml of deionized water to After magnetic stirring at room temperature for 30 min to dissolve into a solution, the PVA and CS were fully mixed and placed under magnetic stirring at 40 °C for 1 h.

[0042] (2) 58mg phytic acid solution and 75mg magnesium chloride hexahydrate are stirred and mixed, the configured magnesium phytate solution is added to the mixed sol in step 1 at room temperature, and the 0.1mol / ml NaOH aqueous solution of 3ml is added to adjust the pH to 6 , after fully mixing, drop the solution statically into the center of the petri dish, and spin the solution at a rate of 800 r / min for 1 min using a spin coater until the solution evenly spreads the petri dish.

[0043] (3) 10ml of 30mg / ml dopamine monomer aqueo...

Example Embodiment

[0046] Example 2

[0047] (1) Dissolve 12g of PVA particles in 50ml of deionized water, and heat it in a water bath at 90°C for 1 h to fully magnetically stir it into a solution state, dissolve 2g of CS powder in 10ml of 0.2% acetic acid solution, and add 30ml of deionized water at room temperature. Magnetic stirring was conducted for 30 min to dissolve into a solution, and then PVA and CS were fully mixed and placed under magnetic stirring at 40 °C for 1 h.

[0048] (2) 116mg phytic acid solution and 150mg magnesium chloride hexahydrate are stirred and mixed, the configured magnesium phytate solution is added to the mixed sol in step 1 at room temperature, and the 0.1mol / ml NaOH aqueous solution of 5ml is added to adjust the pH to 6 , after fully mixing, drop the solution statically into the center of the petri dish, and spin the solution at a rate of 700 r / min for 1 min using a homogenizing spin coater until the solution evenly spreads the petri dish.

[0049] (3) 10ml of 5...

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Abstract

The invention discloses a double-network hydrogel film with single-side hydrophobicity and a preparation method thereof. The film comprises a hydrogel inner layer A, a fatty acid monoglyceride middle layer B and a single-side hydrophobic outer layer C. The preparation method comprises the following steps: physically cross-linking polyvinyl alcohol and a chitosan solution, adding magnesium phytate as a stimulation reactant into the polyvinyl alcohol and the chitosan solution, paving hydrogel on a culture dish by using a spin coating method, adding a dopamine solution before solidification, standing, and performing freezing and unfreezing circulation to form a dual-network hydrogel system; soaking the hydrogel in the prepared glycerol monolaurate film forming liquid to form a middle antibacterial transition layer; spin-coating a polyurethane/organic silicon modified polymer on a single surface of the middle antibacterial transition layer to form a hydrophobic outer layer, and then drying at room temperature to form a hydrogel film integrating antibacterial property, proper mechanical property, good biocompatibility and proper degradation rate.

Description

technical field [0001] The invention relates to chemical materials and a preparation method, in particular to a double-network hydrogel film with one-sided hydrophobicity and a preparation method thereof. Background technique [0002] In urology, the problem of urethral repair has always been one of the thorniest problems for clinical surgeons. Congenital deformities, inflammation, trauma or tumors and other diseases cause urethral damage, stenosis or defect, which needs to be repaired and reconstructed accordingly. With the development of medical level, alternative materials such as autologous skin, mucous membrane and tissue engineering scaffolds have been widely used, which can provide the necessary support structure and pores for cells, but traditional tissue engineering technology has problems in controlling porosity, microstructure and pore junction Difficulty, which limits cell ingrowth and the exchange of nutrients and cellular waste. [0003] At present, biodegrada...

Claims

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Application Information

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IPC IPC(8): A61L27/20A61L27/16A61L27/18A61L27/52A61L27/54A61L27/56A61L27/58A61F2/04
CPCA61L27/20A61L27/16A61L27/18A61L27/56A61L27/54A61L27/58A61L27/52A61F2/04A61L2300/216A61L2300/404A61L2430/22A61F2002/047C08L5/08C08L29/04C08L79/04C08L83/04C08L75/04
Inventor 白晶叶昕王先丽程兆俊薛烽
Owner SOUTHEAST UNIV
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