Unlock instant, AI-driven research and patent intelligence for your innovation.

Drug-loaded polydopamine coated nanofiber dressing and preparation method thereof

A nanofiber, polydopamine technology, applied in the direction of fiber chemical characteristics, medical science, single-component polyester rayon, etc., can solve the problems of decreased activity of antibacterial drugs, spinning difficulties, etc., to speed up healing and speed up wound healing. effect of speed

Pending Publication Date: 2022-02-01
GUANGDONG UNIV OF TECH
View PDF0 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method may have spinning difficulties and a decrease in the activity of antibacterial drugs due to the high pressure

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Drug-loaded polydopamine coated nanofiber dressing and preparation method thereof
  • Drug-loaded polydopamine coated nanofiber dressing and preparation method thereof
  • Drug-loaded polydopamine coated nanofiber dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) Preparation of spinning solution: take polycaprolactone with a molecular weight of 70000-90000 and add it to chloroform / methanol, the volume ratio of chloroform to methanol is 2:1, stir under the condition of magnetic stirring, stir The rotational speed of the method is 300-400 rpm, the stirring time is 6-12 hours, and the solution concentration of polycaprolactone is 12% (w / v).

[0026] (2) Electrospinning the spinning solution to obtain the matrix material of the drug-loaded polydopamine-coated nanofiber dressing.

[0027] The electrospinning process is as follows:

[0028] Step 1: Adjust the ambient temperature and humidity in the operating room to ensure that the spinning environment temperature is 20°C to 40°C and the humidity is within the range of 50% to 70%.

[0029] Step 2: Take a piece of silicone oil paper, paste the silicone oil paper on the roller collector, completely cover the roller collector, the diameter of the roller collector is 10cm.

[0030] ...

Embodiment 2

[0047] (1) Preparation of spinning solution: take polycaprolactone with a molecular weight of 70000-90000 and add it to chloroform / methanol, the volume ratio of chloroform to methanol is 2:1, stir under the condition of magnetic stirring, stir The rotational speed of the method is 300-400 rpm, the stirring time is 6-12 hours, and the solution concentration of polycaprolactone is 12% (w / v).

[0048] (2) Electrospinning the spinning solution to obtain the matrix material of the drug-loaded polydopamine-coated nanofiber dressing.

[0049] The electrospinning process is as follows:

[0050] Step 1: Adjust the ambient temperature and humidity in the operating room to ensure that the spinning environment temperature is 20°C to 40°C and the humidity is within the range of 50% to 70%.

[0051] Step 2: Take a piece of silicone oil paper, paste the silicone oil paper on the roller collector, completely cover the roller collector, the diameter of the roller collector is 10cm.

[0052] ...

Embodiment 3

[0069] (1) Preparation of spinning solution: take polycaprolactone with a molecular weight of 70000-90000 and add it to chloroform / methanol, the volume ratio of chloroform to methanol is 2:1, stir under the condition of magnetic stirring, stir The rotational speed of the method is 300-400 rpm, the stirring time is 6-12 hours, and the solution concentration of polycaprolactone is 12% (w / v).

[0070] (2) Electrospinning the spinning solution to obtain the matrix material of the drug-loaded polydopamine-coated nanofiber dressing.

[0071] The electrospinning process is as follows:

[0072] Step 1: Adjust the ambient temperature and humidity in the operating room to ensure that the spinning environment temperature is 20°C to 40°C and the humidity is within the range of 50% to 70%.

[0073] Step 2: Take a piece of silicone oil paper, paste the silicone oil paper on the roller collector, completely cover the roller collector, the diameter of the roller collector is 10cm.

[0074] ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
diameteraaaaaaaaaa
diameteraaaaaaaaaa
Login to View More

Abstract

The invention belongs to the technical field of wound dressings, and particularly relates to a drug-loaded polydopamine coated nanofiber dressing and a preparation method thereof. According to the wound dressing, polycaprolactone nanofibers are used as a base material, firstly, synthesis of polydopamine coated nanofibers is carried out, and then through loading of epsilon-polylysine, a nanofiber membrane which has the antibacterial effect, the photothermal effect and the anti-oxidation characteristic at the same time is prepared. The wound dressing is simple in preparation process and non-toxic. Experiments prove that the drug-loaded polydopamine coated nanofiber dressing is successfully prepared and has a high antioxidant effect. Bacteriostatic experiments prove that the nanofiber dressing has good bacteriostatic ability. Cell experiments prove that the nanofiber dressing is non-toxic. The drug-loaded polydopamine coated nanofiber dressing is simple to prepare and has a wide application prospect in the field of wound dressings.

Description

technical field [0001] The invention belongs to the technical field of wound dressings, in particular to a method for preparing nanofiber dressings based on surface chemical modification technology. Background technique [0002] When human tissue is traumatized, bacterial infection is the main factor that causes wounds not to heal in time. Therefore, the use of antibacterial dressings to prevent and treat wounds has become the main means. Antibacterial dressings currently used clinically mainly use highly toxic silver ions as antibacterial components, which can easily cause adverse reactions such as argyria, allergies, and liver damage. Therefore, dressings with antibacterial biological activity are of great significance for clinical wound healing. Research in recent years has also developed some wound dressings such as hydrogels, films, and nanofiber membranes. The nanofibrous membrane prepared by electrospinning has the characteristics of high specific surface area, hig...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): D04H1/728D04H1/435D01F6/62
CPCD04H1/728D04H1/435D01F6/625D10B2509/022D10B2401/13
Inventor 汤亚东刘育荣蓝兴梓王雅琦田枫赖相捷段宇洁罗玉立
Owner GUANGDONG UNIV OF TECH
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com