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Preparation process of traditional Chinese medicine compound oral liquid

A preparation process and oral liquid technology are applied in the field of preparation of traditional Chinese medicine compound oral liquid to achieve the effects of increasing stability, reducing content and saving time and processes

Pending Publication Date: 2022-02-15
GUANGZHOU BAIYUNSHAN MINGXING PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Qingkailing oral liquid currently has mature technology and quality standards, and the product quality is basically stable, but there is still potential for further improvement

Method used

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  • Preparation process of traditional Chinese medicine compound oral liquid
  • Preparation process of traditional Chinese medicine compound oral liquid
  • Preparation process of traditional Chinese medicine compound oral liquid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] prescription:

[0030] Cholic acid 4 parts, mother of pearl 55 parts, hyodeoxycholic acid 4 parts, gardenia 28 parts,

[0031] 28 parts of buffalo horn, 220 parts of isatidis, 6 parts of baicalin and 65 parts of honeysuckle.

[0032] Preparation Process:

[0033] (1) Mix isatidis, gardenia and honeysuckle, add water and decoct to extract twice, each time for 1 hour, combine the extracts, concentrate to a clear paste with a relative density of 1.15-1.20 at 50°C, add ethanol, let stand, filter, and recover ethanol , add water to obtain the extract;

[0034] (2) Grind buffalo horn, mix with mother of pearl, add sulfuric acid to hydrolyze, filter, adjust the pH of the filtrate to 4±0.5 with 15% calcium hydroxide solution, add ethanol, let it stand, filter, recover ethanol, add water, and obtain hydrolysis liquid;

[0035] (3) Cholic acid and hyodeoxycholic acid are dissolved in ethanol, the extract and hydrolyzate are combined, then added to the ethanol solution of chol...

Embodiment 2

[0039] prescription:

[0040] Cholic acid 3 parts, mother of pearl 45 parts, hyodeoxycholic acid 2 parts, gardenia 22 parts,

[0041] 22 parts of buffalo horn, 180 parts of isatidis, 4 parts of baicalin and 55 parts of honeysuckle.

[0042] Preparation Process:

[0043] (1) Mix isatidis, gardenia and honeysuckle, add water and decoct to extract twice, each time for 1 hour, combine the extracts, concentrate to a clear paste with a relative density of 1.15-1.20 at 50°C, add ethanol, let stand, filter, and recover ethanol , add water to obtain the extract;

[0044] (2) Grind buffalo horn, mix with mother of pearl, add sulfuric acid to hydrolyze, filter, adjust the pH of the filtrate to 4±0.5 with 15% calcium hydroxide solution, add ethanol, let it stand, filter, recover ethanol, add water, and obtain hydrolysis liquid;

[0045] (3) Cholic acid and hyodeoxycholic acid are dissolved in ethanol, the extract and hydrolyzate are combined, then added to the ethanol solution of chol...

Embodiment 3

[0049] prescription:

[0050] Cholic acid 3.25 parts, mother of pearl 50 parts, hyodeoxycholic acid 3.75 parts, gardenia 25 parts,

[0051] 25 parts of buffalo horn, 200 parts of isatidis, 5 parts of baicalin and 60 parts of honeysuckle.

[0052] Preparation Process:

[0053] (1) Mix isatidis, gardenia and honeysuckle, add water and decoct to extract twice, each time for 1 hour, combine the extracts, concentrate to a clear paste with a relative density of 1.15-1.20 at 50°C, add ethanol, let stand, filter, and recover ethanol , add water to obtain the extract;

[0054] (2) Grind buffalo horn, mix with mother of pearl, add sulfuric acid to hydrolyze, filter, adjust the pH of the filtrate to 4±0.5 with 15% calcium hydroxide solution, add ethanol, let it stand, filter, recover ethanol, add water, and obtain hydrolysis liquid;

[0055] (3) Cholic acid and hyodeoxycholic acid are dissolved in ethanol, the extract and hydrolyzate are combined, then added to the ethanol solution o...

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Abstract

The invention discloses a preparation process of a traditional Chinese medicine compound oral liquid. The traditional Chinese medicine compound oral liquid is mainly prepared from cholic acid, nacre mother of pearl, hyodeoxycholic acid, gardenia fruit, cornu bubali, isatis roots, baicalin and honeysuckle flowers. The preparation process comprises the following steps: (1) mixing the isatis roots, the gardenia fruit and the honeysuckle flowers, adding water for extraction, and performing alcohol precipitation, filtration and alcohol removal on an obtained extract to obtain a liquid extract; (2) grinding the cornu bubali into powder, mixing the ground cornu bubali with the nacre mother of pearl, adding acid for hydrolysis, performing alcohol precipitation on reaction liquid, conducting filtering, and removing alcohol to obtain hydrolysate; (3) mixing the liquid extract, the hydrolysate and an alcoholic solution of cholic acid and hyodeoxycholic acid, and carrying out alcohol precipitation, filtration and alcohol removal to obtain a mixed solution; (4) enabling the mixed solution to flow through the surface of an ultrafiltration membrane at a certain speed for ultrafiltration, wherein the molecular weight cutoff of the ultrafiltration membrane is 60000-80000 Daltons; and (5) finally, adding the baicalin and auxiliary materials, and adjusting a pH value to obtain the traditional Chinese medicine compound oral liquid. By adopting the novel process, the quality and the stability of the oral liquid can be remarkably improved.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine oral liquid, in particular to a preparation process of traditional Chinese medicine compound oral liquid. Background technique [0002] Chinese herbal medicine is a great treasure of Chinese civilization. It has a history of thousands of years and continues to this day. Generally speaking, Chinese herbal medicines cannot be taken or used directly. Whether it is ordinary people decocting Chinese herbal medicines or pharmaceutical companies preparing Chinese herbal medicine preparations, the active ingredients in the plant raw materials must be released and transferred into the solution, so that their efficacy can be conveniently taken and used, and be recognized by the public. Absorbs smoothly. Traditional Chinese medicine oral liquid refers to the liquid preparation for oral administration made by extracting medicinal materials with water or other solvents by appropriate meth...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61K9/08A61P29/00A61P25/20A61P11/04A61P43/00A61P11/00A61P31/16A61K35/618A61K35/32A61K31/7048A61K31/575
CPCA61K31/575A61K35/618A61K36/744A61K35/32A61K36/195A61K36/315A61K31/7048A61K36/355A61K9/0095A61P29/00A61P25/20A61P11/04A61P43/00A61P11/00A61P31/16A61K2236/331A61K2236/53A61K2236/51A61K2236/333A61K2300/00
Inventor 陈红英陈昆南黄卉周小琴王福坚
Owner GUANGZHOU BAIYUNSHAN MINGXING PHARM CO LTD
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