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Traditional Chinese medicine composition for preventing and treating thalassemia

A technology of thalassemia and composition, applied in the field of biomedicine, to achieve the effects of broadening the scope of indications, relieving/therapeutic effect, and significant/therapeutic effect

Pending Publication Date: 2022-02-22
ZHUZHOU QIANJIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no relevant research to explore whether this traditional Chinese medicine prescription still has an effect on other types of anemia such as thalassemia and how effective it is.

Method used

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  • Traditional Chinese medicine composition for preventing and treating thalassemia
  • Traditional Chinese medicine composition for preventing and treating thalassemia
  • Traditional Chinese medicine composition for preventing and treating thalassemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 1. Experimental method

[0025] (1) Traditional Chinese medicine prescription: The traditional Chinese medicine composition includes 100 parts of angelica, 100 parts of astragalus, 30 parts of donkey-hide gelatin, 150 parts of motherwort, and 3 parts of tangerine peel. The method of preparation is as described above.

[0026] (2) Experimental animals

[0027] β654 thalassemia mice were purchased from Jackson Laboratory (Bar Harbor, ME, USA) and raised in SPF environment.

[0028] (3) Animal handling

[0029] β654 thalassemia mice were fed with common diet for four weeks, and were randomly divided into control group and experimental group according to body weight, with 6 mice in each group. The control group was fed with common feed, and the experimental group was fed with 1% of the traditional Chinese medicine obtained in Example 1 in the common feed of the control group, and fed continuously for 8 weeks.

[0030] (4) Indicator detection

[0031] Mice were anesthet...

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Abstract

The invention discloses an application of a traditional Chinese medicine composition in preparation of a medicine for relieving / treating thalassemia. The traditional Chinese medicine composition comprises angelica sinensis, astragalus membranaceus, colla corii asini, leonurus japonicus and pericarpium citri reticulatae. The composition can improve the hematological phenotype of beta thalassemia mice, increase the number of red blood cells, the content of hemoglobin and hematocrit, and reduce the content of serum iron and liver iron; the traditional Chinese medicine composition disclosed by the invention has an obvious relieving / treating effect on the thalassemia, not only widens the adaptation disease range of the components, but also provides a new traditional Chinese medicine formula choice for relieving / treating the thalassemia, and has an obvious application value for relieving / treating the thalassemia.

Description

technical field [0001] The invention belongs to the technical field of biomedicine. More specifically, it relates to the application of a traditional Chinese medicine composition in preventing and treating thalassemia. Background technique [0002] Anemia refers to a common clinical symptom in which the peripheral red blood cell volume of the human body is reduced, which is lower than the lower limit of the normal range. The classification and causes of anemia are complex. There are different classifications of anemia based on different clinical features. Such as: acute and chronic anemia according to the progress of anemia; macrocytic anemia, normocytic anemia and microcytic hypochromic anemia according to the shape of red blood cells; mild, moderate, severe and very severe anemia according to hemoglobin concentration; Bone marrow erythroid hyperplasia is divided into proliferative anemia (such as hemolytic anemia, iron deficiency anemia, megaloblastic anemia, etc.) and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752A61P7/06A61K35/36
CPCA61K36/232A61K36/481A61K35/36A61K36/533A61K36/752A61P7/06A61K2236/331A61K2236/39A61K2236/333A61K2300/00
Inventor 李伏君张鹏冯鑫吴梦瑶张素英颜利玲钟爱军荣苑君王英
Owner ZHUZHOU QIANJIN PHARMA
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