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Auto-curing amorphous hydrogel pressure sore dressing and preparation method thereof

A hydrogel and amorphous technology, applied in medical science, bandages, etc., can solve problems such as inability to achieve close fit, and achieve the effect of improving the overall strength

Pending Publication Date: 2022-02-22
XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to solve the problem that the prior art needs to rely on medical adhesive tape as the bearing matrix, and irregular pressure sores need to be cut in advance before feeding, and effective close fit cannot be achieved, and to provide an automatic curing Amorphous hydrogel pressure ulcer dressing and preparation method thereof

Method used

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  • Auto-curing amorphous hydrogel pressure sore dressing and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1: The preparation method of preparing a self-curing amorphous hydrogel pressure sore dressing comprises the following steps:

[0045] (1) Press and knead the hydroxymethyl cellulose with a shear strain of 50% for later use, heat the water environment to ~75°C, maintain a vibration frequency of 3.5 Hz, add the hydroxymethyl cellulose after pressure tanning pretreatment, and maintain the temperature vibration Treat for 350s to complete the disentanglement of hydroxymethyl cellulose;

[0046] (2) Hydroxyethyl methacrylate and 2-hydroxyethyl acrylate were stirred and blended at a speed of 1200r / min for 10 minutes in a water environment, then heated to 45.5°C, kept stirring, and copolymerized for 20 minutes to obtain a primary coupling agent;

[0047] (3) Add chitosan after the hydroxymethyl cellulose disentangled under water environment in step (1) and the primary coupling agent product in step (2) are mixed naturally under water environment, after fully stirri...

Embodiment 2

[0055] Embodiment 2: The preparation method of preparing a self-curing amorphous hydrogel pressure sore dressing comprises the following steps:

[0056] (1) Press and knead hydroxymethyl cellulose with 50% shear strain for later use, heat the water environment to ~75°C, maintain a vibration frequency of 3.5 Hz, add hydroxymethyl cellulose after pressure tanning pretreatment, and maintain temperature vibration Treat for 350s to complete the disentanglement of hydroxymethyl cellulose;

[0057] (2) Hydroxyethyl methacrylate and 2-hydroxyethyl acrylate were stirred and blended at a speed of 1200r / min for 10 minutes in a water environment, then heated to 45.5°C, kept stirring, and copolymerized for 20 minutes to obtain a primary coupling agent;

[0058] (3) Add chitosan after the hydroxymethyl cellulose disentangled under the water environment in step (1) and the primary coupling agent product in the step (2) are mixed naturally under the water environment, after fully stirring an...

Embodiment 3

[0066] Embodiment 3: The preparation method of preparing a self-curing amorphous hydrogel pressure sore dressing comprises the following steps:

[0067] (1) Press and knead the hydroxymethyl cellulose with a shear strain of 50% for later use, heat the water environment to ~75°C, maintain a vibration frequency of 3.5 Hz, add the hydroxymethyl cellulose after pressure tanning pretreatment, and maintain the temperature vibration Treat for 350s to complete the disentanglement of hydroxymethyl cellulose;

[0068] (2) Hydroxyethyl methacrylate and 2-hydroxyethyl acrylate were stirred and blended at a speed of 1200r / min for 10 minutes in a water environment, then heated to 45.5°C, kept stirring, and copolymerized for 20 minutes to obtain a primary coupling agent;

[0069] (3) Add chitosan after the hydroxymethyl cellulose disentangled under water environment in step (1) and the primary coupling agent product in step (2) are mixed naturally under water environment, after fully stirri...

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Abstract

The invention discloses an auto-curing amorphous hydrogel pressure sore dressing and a preparation method thereof. The auto-curing amorphous hydrogel pressure sore dressing comprises a hydrogel base body, an auto-curing surrounding layer wrapping the hydrogel base body and a sealing packaging film wrapping the auto-curing surrounding layer in a sealed mode, and the hydrogel base body comprises an upper hydrogel base body, a lower hydrogel matrix and an elastic reinforcing interlayer clamped and fixed between the upper hydrogel matrix and the lower hydrogel matrix, 10-80 parts of hydroxymethyl cellulose, 3-9 parts of chitosan, 1-4 parts of hydroxyethyl methylacrylate, 5-20 parts of 2-hydroxyethyl acrylate, 5-160 parts of glycerin and 0.8-2 parts of a preservative are adopted to construct a cellulose coupling colloid, deionized water is matched to construct the hydrogel matrix, the external rapid curing is achieved by using the acrylate microgel emulsion, the internal reinforcement is achieved by using the guar gum and the hydrolyzed elastin, and the product has advantages of no need of the adhesive tape base material in the traditional hydrogel dressing, no shaping structure before the whole curing, free shaping according to the pressure sore wound surface, and good skin fitting property and good comfort.

Description

technical field [0001] The invention relates to the field of medical consumables, in particular to a self-curing amorphous hydrogel pressure sore dressing and a preparation method thereof. Background technique [0002] Pressure sores are due to long-term pressure on local tissues, resulting in continuous ischemia, hypoxia, and malnutrition, resulting in tissue ulceration and necrosis. In surgical patients under anesthesia, due to the loss of all or part of the body's consciousness, the muscles lose their ability to regulate themselves, which is more likely to cause pressure sores. Skin injury, the chance of acute pressure sore during operation is relatively increased. According to the US National Decubitus Advisory Group, one million people suffer from pressure sores in the United States alone, 5.8% of hospitalized patients in Japan have pressure sores, and the incidence of pressure sores in hospitals is 3% to 14%. Paralyzed patients and elderly patients are more likely to ...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0095A61L26/0023A61L26/008A61L26/0047A61L26/0061
Inventor 陈静
Owner XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV