Lesion DNA recognition method and device, electronic equipment and storage medium

Abstract

The invention provides a lesion DNA recognition method and device, electronic equipment and a storage medium. The method comprises the following steps: acquiring a to-be-detected DNA sequence, and preprocessing the to-be-detected DNA sequence to obtain a plurality of DNA sequence fragments; for each DNA sequence fragment, inputting the DNA sequence fragment into a trained first neural network model to output a first feature vector corresponding to the DNA sequence fragment; for each first feature vector, inputting the first feature vector into a trained second neural network model to output a second feature vector corresponding to the first feature vector, and adding the first feature vector and the corresponding second feature vector to obtain a combined feature vector; and inputting each combined feature vector into a trained classifier to obtain a classification result, wherein the classification result indicates whether the input DNA sequence to be detected is lesion DNA or not. According to the invention, the accuracy of lesion DNA recognition can be improved.

Description

Technical field [0001] The present invention relates to the field of biological information technology and neural network applications, and more particularly to a lesion DNA identification method, apparatus, electronic device, and storage medium. Background technique [0002] Cell DNA (CFDNA) in plasma, urine and cerebrospinal fluid is mainly released by apoptosis or necrotic cells into a degradation DNA fragment in the body fluid. In terms of tissue lesions and cancer, when the patient did not have a significant clinical symptom, the DNA state in lesion cells or cancer cells had changed and released into the body fluid, so it can be detected in the body fluid in cancer or various diseases. To the trace cycle disease DNA (CTDNA). With the development of high-throughput sequencing technology, the micro-liquid biopsy method is becoming a diagnosis of disease diagnosis by recognizing traces in a large amount of CFDNA sequencing data. [0003] However, the existing technical means is...

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Problems solved by technology

[0004] The present invention provides a lesion DNA identification method, device, electronic equipment and storage medium to solve the problems in the prior art that the ability to identify lesion DNA sequences is poor and requires a large amount of labeled data

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