Emulsion containing royal jelly enzymolysis polypeptide and preparation method thereof

A technology of royal jelly enzyme and royal jelly, which is applied in the field of emulsion containing royal jelly enzymatic polypeptide and its preparation, can solve the problems of difficult absorption and utilization, unstable storage, allergic reaction, etc., and achieve the effect of improving color, improving dark yellow and high solubility Effect

Pending Publication Date: 2022-03-01
北京中蜜科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the protein in royal jelly has the disadvantages of causing allergic reactions, unstable storage, and difficult absorption and utilization by human skin.

Method used

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  • Emulsion containing royal jelly enzymolysis polypeptide and preparation method thereof
  • Emulsion containing royal jelly enzymolysis polypeptide and preparation method thereof
  • Emulsion containing royal jelly enzymolysis polypeptide and preparation method thereof

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preparation example Construction

[0041] In the first aspect, the present application provides a method for preparing an emulsion containing royal jelly enzymatically hydrolyzed polypeptide, which comprises the following steps:

[0042] 1) hydrolyzing royal jelly in the presence of trypsin and pepsin, filtering and freeze-drying to obtain pretreated royal jelly enzymatic polypeptide powder;

[0043] 2) Mixing the pretreated royal jelly enzymatic polypeptide powder and β-cyclodextrin aqueous solution while stirring, then homogenizing, and freeze-drying to obtain royal jelly enzymatic polypeptide solid particles;

[0044] 3) Mix the chelating agent, the skin conditioner, and the moisturizer evenly to obtain mixture A;

[0045] 4) adding an emollient to part of the mixture A under negative pressure, stirring evenly, adding the remaining mixture A, stirring evenly, and then homogenizing, then adding an emulsifier, stirring evenly, and then homogenizing; and

[0046] 5) Control the temperature of the product obtai...

Embodiment 1

[0073] The following preparation method is used to prepare the emulsion containing royal jelly enzymatic polypeptide according to the present application:

[0074] 1) Adjust the pH value of the royal jelly aqueous solution with a substrate concentration of 80% to 8.0, add trypsin with a substrate concentration ratio of 0.6% and 0.4% pepsin, and hydrolyze at a constant temperature of 45°C for 6 hours, then at 85°C Heating at low temperature for 30 minutes to inactivate protease, filtering, and pre-cooling the filtrate for 4 hours, then freeze-drying for 48 hours in a low-pressure environment at -80°C to obtain pretreated royal jelly enzymatic polypeptide powder;

[0075] 2) While stirring, the pretreated royal jelly enzymatic polypeptide powder with a mass ratio of 1:7 was mixed with an aqueous solution of β-cyclodextrin with a mass concentration of 5%, and then homogenized under a pressure of 35 MPa for 30 minutes, Then freeze-dry under a low-pressure environment at -80°C to obt...

Embodiment 2

[0080] In addition to using 3g of royal jelly hydrolyzed polypeptide, 0.04g of skin conditioner (containing 0.02g of sodium hyaluronate and 0.02g of soluble collagen), 6g of moisturizing agent (containing 2.3g of propylene glycol, 1.4g of butylene glycol and 2.3 g of isopentyl glycol), 8 g of emollient (containing 2 g of isononyl isononanoate, 2 g of C13-16 isoparaffin, 2 g of capric triglyceride, 1.0 g of dimethicone Oxane, 0.7g of mineral oil and 0.3g of C10-13 isoparaffin), 0.1g of plant extracts (including 0.015g of glabra root extract, 0.015g of Aloe vera leaf extract, 0.015 g of Centella asiatica extract, 0.015g of snow lotus flower extract and 0.04g of peony root extract), 0.02g of chelating agent EDTA disodium salt and 2.4g of emulsifier (containing 0.4g of cetearyl alcohol, 0.4g of glyceryl stearate, 0.4g of PEG-100 stearate, 0.4g of PEG-40 sorbitan stearate, 0.4g of potassium cetyl phosphate and 0.4g of Except for polysorbate-80), the emulsion containing royal jelly...

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Abstract

The invention relates to an emulsion containing royal jelly enzymolysis polypeptide and a preparation method thereof. According to the preparation method, firstly, the royal jelly is subjected to enzymolysis to decompose protein in the royal jelly to obtain royal jelly polypeptide, then components such as beta-cyclodextrin are adopted and freeze-dried to stabilize the royal jelly enzymolysis polypeptide and maintain the activity of the royal jelly enzymolysis polypeptide, and then emulsion components and plant extracts are mixed to obtain the emulsion containing the royal jelly enzymolysis polypeptide. The preparation method can effectively perform enzymolysis on protein which is easy to cause skin anaphylaxis in the royal jelly, so that the repairing effect of the emulsion is improved, and the prepared emulsion is excellent in storage stability. Besides, according to the emulsion containing the royal jelly enzymolysis polypeptide, the dark yellow condition of the skin can be remarkably improved, the brightness of the skin is improved, the color of the skin is improved, and the emulsion is a functional skin care product suitable for various skin types.

Description

Technical field: [0001] The application belongs to the field of cosmetics, and in particular relates to an emulsion containing royal jelly enzymatic polypeptide and a preparation method thereof. Background technique: [0002] Aging is a complex, multifactorial process characterized by a gradual decline in the body's physiological functions and ability to regulate metabolic stress. Skin aging shows changes in appearance and function, and the exogenous factors affecting skin aging are mainly ultraviolet radiation. The destruction of collagen in the dermis of the skin is at the heart of skin aging. Therefore, rebuilding the collagen in the dermis of the skin is an effective way to prevent skin aging, which includes two aspects, namely promoting the synthesis of collagen and inhibiting the activity of Matrix Metalloproteinases (MMPS). [0003] In recent years, the development of skin biology has gradually helped people understand the homeostasis of the skin and its aging proce...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/64A61K8/9794A61K8/9789A61K8/73A61K8/34A61K8/60A61K8/06A61Q19/02A61Q19/00C12P21/06C07K1/34
CPCA61K8/64A61K8/9794A61K8/9789A61K8/738A61K8/345A61K8/60A61K8/06A61Q19/02A61Q19/00C12P21/06C07K1/34A61K2800/84A61K2800/805A61K2800/592A61K2800/782A61K2800/524
Inventor 曹珍艳高凌宇冯浩然张杨童越敏王秀红
Owner 北京中蜜科技发展有限公司
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