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Self-curing 3D printing bio-ink as well as preparation method and application thereof

A bio-ink and 3D printing technology, applied in tissue regeneration, medical science, prosthesis, etc., can solve the problems of poor self-curing properties of α-TCP, complex organic binder preparation process, etc., and achieve excellent apatite deposition ability , regular pore structure and high porosity

Inactive Publication Date: 2022-03-01
CHANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Technical problem solved: In view of the above technical problems, the present invention provides a self-curing 3D printing bio-ink and its preparation method and application, which overcomes the poor self-curing characteristics of α-TCP and the preparation of organic binders in the prior art The shortcomings of the complex process are not only easy to 3D print and shape, but also can be self-cured under mild conditions, and can also be loaded with drugs, proteins and growth factors, etc., and can be co-printed with biologically active substances

Method used

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  • Self-curing 3D printing bio-ink as well as preparation method and application thereof
  • Self-curing 3D printing bio-ink as well as preparation method and application thereof
  • Self-curing 3D printing bio-ink as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] First weigh the solids in the following parts by weight: 30 parts of hydroxyapatite powder and 70 parts of tricalcium silicate powder, then put them into a container and use a magnetic stirrer for mechanical mixing to form a uniform solid phase powder; then weigh Add 2g of polyether F127 into 18g of deionized water, and form a polyether F127 solution after stirring continuously; mix the polyether F127 solution with hydroxyapatite / tricalcium silicate composite solid phase powder at a mass ratio of 0.38:1g / g Modulate to obtain 3D printing slurry with flow characteristics; then put the slurry into the barrel of the 3D printer with a needle diameter of 0.6mm, extrude it under 600-800kPa air pressure according to the shape set by the software, and then Curing yields a cylindrical scaffold.

[0029] figure 1 It is a digital photo of the printed stent. It can be seen from the figure that the material can print a three-dimensional through-hole stent with regular shape and pore...

Embodiment 2

[0031] First weigh the solids in the following parts by weight: 40 parts of hydroxyapatite powder and 60 parts of tricalcium silicate powder, then put them into a container and use a magnetic stirrer for mechanical mixing to form a uniform solid phase powder; then weigh Add 2g of polyether F127 into 18g of deionized water, and form a polyether F127 solution after stirring continuously; mix the polyether F127 solution with hydroxyapatite / tricalcium silicate composite solid phase powder at a mass ratio of 0.4:1g / g Modulate to obtain 3D printing slurry with flow characteristics; then put the slurry into the barrel of the 3D printer with a needle diameter of 0.6mm, extrude it under 600-800kPa air pressure according to the shape set by the software, and then Curing yields a cylindrical scaffold.

[0032] image 3 It is a digital photo of the printed stent. It can be seen from the figure that the material can print a three-dimensional through-hole stent through a 3D printing device...

Embodiment 3

[0034]First weigh the solids in the following parts by weight: 50 parts of hydroxyapatite powder and 50 parts of tricalcium silicate powder, then put them into a container and use a magnetic stirrer for mechanical mixing to form a uniform solid phase powder; then weigh Add 2g of polyether F127 into 18g of deionized water, and form a polyether F127 solution after stirring continuously; mix the polyether F127 solution with hydroxyapatite / tricalcium silicate composite solid phase powder at a mass ratio of 0.42:1g / g Modulate to obtain 3D printing slurry with flow characteristics; then put the slurry into the barrel of the 3D printer with a needle diameter of 0.6mm, extrude it under 600-800kPa air pressure according to the shape set by the software, and then Curing yields a cylindrical scaffold.

[0035] Figure 4 and Figure 5 It is the surface topography diagram of the prepared scaffold soaked in simulated body fluid. It can be seen from the figure that the surface of the scaff...

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Abstract

The invention discloses self-curing 3D printing bio-ink as well as a preparation method and application thereof, and belongs to the field of biomedical materials. The biological ink comprises hydroxyapatite, a silicon-calcium-based self-curing material and a polyether F127 solution, wherein the silicon-calcium-based self-curing material is selected from one or more of tricalcium silicate and dicalcium silicate; the mass ratio of the hydroxyapatite to the silicon-calcium-based self-curing material is (0.05-20): 1; the mass concentration of the polyether F127 solution is 5-25%; the ratio of the total mass of the hydroxyapatite and the silicon-calcium-based self-curing material to the mass of the polyether F127 solution is 1: (0.25-0.5). The defects that in the prior art, alpha-TCP is poor in self-curing characteristic and an organic binder preparation technology is complex are overcome, 3D printing forming is easy, self curing is achieved under the mild condition, medicine, protein, growth factors and the like can be loaded, and co-printing with bioactive substances can be achieved.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a self-curing 3D printing bio-ink and its preparation method and application. Background technique [0002] The problem of bone defects caused by trauma, bone tumors, infections, and diseases related to population aging is becoming more and more serious. The repair and reconstruction based on bone repair material transplantation is an effective strategy for the treatment of bone defects in patients. Hydroxyapatite bioactive ceramic materials are similar in composition and structure to the inorganic components in human hard tissues, and have good osteoconductivity, biocompatibility and bioactivity, so they are widely used in clinical bone defect repair treatment . Porous scaffolds can not only provide carrier support for cell adhesion and growth, but also facilitate the transportation of growth factors, nutrients, and metabolic waste, thus effectively acceleratin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/02A61L27/18A61L27/56A61L27/50B33Y70/10B33Y80/00B33Y10/00
CPCA61L27/12A61L27/025A61L27/18A61L27/56A61L27/50B33Y70/10B33Y80/00B33Y10/00A61L2430/02C08L71/02
Inventor 吴蒙吴王平
Owner CHANGZHOU UNIV
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