Multifunctional electrode array system for cell biochemical signal detection and regulation

Abstract

The invention relates to a multifunctional electrode array system for cell biochemical signal detection and regulation. The multifunctional electrode array system comprises an N * N array module, a TDC counting module, an array power supply LDO module, an electrical stimulation generator, a row and column selection control module, a finite-state machine and a digital control logic module, the N * N array module is formed by combining N * N pixel units and is used for being in contact with nerve cells and converting collected analog signals into pulse width modulation signals (PWM waves); the TDC counting module is used for converting pulse width modulation signals (PWM waves) in the array into digital signals and transmitting the digital signals to the finite-state machine and the digital control logic module. Four simulation units with different functions are integrated in a front-end array, and a corresponding system reading framework is designed, so that interference in pixels is eliminated, various ions are detected at the same time, the chip function complexity is improved, the system power consumption is reduced, and a convenient detection platform is provided for biological detection.

Description

technical field [0001] The invention relates to the technical field of analog integrated circuits, in particular to a multifunctional electrode array system for detecting and regulating cell biochemical signals. Background technique [0002] Nerve cells are accompanied by complex electrical and chemical phenomena in the process of producing movements, and obtaining detailed nerve signals is helpful for further research on nerve cells. At the same time, nerve electrical stimulation regulation can give specific stimulation to nerve cells according to the needs, and then combine with the sensing part to realize the closed-loop system analysis of nerve cells. In order to realize an integrated sensing and regulating system and satisfy cell-level resolution, a miniaturized sensing and regulating platform is required. The integrated circuit technology uses advanced micro-nano processing technology to realize the integration of micro-complex systems on a single chip, so it is widel...

AI Technical Summary

Problems solved by technology

[0003] At present, the biochips based on integrated circuits have the following problems: 1. The function is single, and multiple functions are integrated together, which increases the complexity and design difficulty of the system; 2. Multiple functions cannot be parallelized

Due to mutual interference between different signal detection electrodes, bioelectrical signals and chemical signals cannot be detected in parallel, which limits the acquired signal dimension; 3. Insufficient spatial resolution

Neurobiological chips with high spatial resolution can obtain the action potential of a single neuron, which is beneficial to further analysis of neural signals, but when multiple functions are integrated, the area of ​​a single pixel unit will increase, and mutual interference will also increase; 4. The size of the array is limited, and large-scale arrays have higher data, requiring higher performance system design; 5. Excessive energy consumption, redundant information, and some electrodes in the array are not attached to nerve cells. The collected signal is redundant, which wastes the power consumption of the circuit

[0004]The development of biochips urgently needs large-scale detection arrays to collect more neuron signals at the same time, and further analyze the cooperative work between nerves, but the scale of chip arrays must be expanded It will increase the power consumption and data volume of the chip, which limits the further expansion of the scale

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