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Medicine formula for treating leukemia

A leukemia and formula technology, which is applied in the field of drug formula for treating leukemia, can solve problems such as ambiguity, and achieve the effects of increasing human body's righteousness, enhancing the curative effect of chemotherapy, and prolonging the survival period

Pending Publication Date: 2022-03-08
陈涵
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Whether NLRP3 / CASPAS-1 signaling pathway is involved in LTL-induced ICD in AML cells remains unclear

Method used

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  • Medicine formula for treating leukemia
  • Medicine formula for treating leukemia
  • Medicine formula for treating leukemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] A drug formula for treating leukemia, comprising: 27 grams of astragalus, 25 grams of Ganoderma lucidum, 12 grams of poria cocos, 12 grams of Chinese yam, 12 grams of Shanzi mushroom, 8 grams of Chonglou, 12 grams of Prunella vulgaris, 25 grams of Hedyotis diffusa, half Zhilian 25 grams.

[0047] The various components of the pharmaceutical formula in this embodiment, after being pulverized, ground, mixed and stirred, can be formed into various pharmaceutical forms such as granules and liquids through conventional manufacturing processes, which are convenient for patients to take.

Embodiment 2

[0049] A medicine formula for treating leukemia in this embodiment, comprising: 33 grams of astragalus, 35 grams of Ganoderma lucidum, 18 grams of Poria cocos, 18 grams of Chinese yam, 18 grams of Arrowhead mushroom, 12 grams of Chonglou, 18 grams of Prunella vulgaris, and Hedyotis diffusa 35 grams, barbata 35 grams.

Embodiment 3

[0051] A medicine formula for treating leukemia according to this embodiment, comprising: 30 grams of astragalus, 30 grams of ganoderma lucidum, 15 grams of Poria cocos, 15 grams of Chinese yam, 15 grams of Arrowhead mushroom, 10 grams of Chonglou, 15 grams of Prunella vulgaris, and Hedyotis diffusa 30 grams, barbata 30 grams.

[0052] For the above formula, verify the efficacy of the formula drug of the present invention and the effectiveness of the pathological mechanism for the treatment of leukemia with water preparation.

[0053] 1. Effects of the formulated drug of the present invention on cell immunogenic death in acute myeloid leukemia cells and molecules related to the Caspase1 / NLRP3 signaling pathway.

[0054] 1.1MTT experiment.

[0055] MTT method, also known as MTT colorimetric method, is a method for detecting cell survival and growth.

[0056] The results of the MTT experiment showed that the formula drugs at three concentration points of 20 μM, 40 μM and 80 μM...

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Abstract

The invention relates to a traditional Chinese medicine formula, in particular to a medicine formula for treating leukemia. The formula comprises 27-33 parts by mass of astragalus membranaceus, 25-35 parts by mass of lucid ganoderma, 12-18 parts by mass of poria cocos, 12-18 parts by mass of Chinese yam, 12-18 parts by mass of edible tulip, 8-12 parts by mass of paris polyphylla, 12-18 parts by mass of selfheal, 25-35 parts by mass of oldenlandia diffusa and 25-35 parts by mass of sculellaria barbata. The medicine formula for treating leukemia disclosed by the invention has an obvious effect on leukemia treatment.

Description

technical field [0001] The invention relates to a traditional Chinese medicine formula, in particular to a medicine formula for treating leukemia. Background technique [0002] Acute myeloid leukemia (AML) is a heterogeneous malignant proliferative disease that occurs in hematopoietic stem / progenitor cells. A large number of leukemia cells proliferate and accumulate in bone marrow and other hematopoietic tissues, inhibiting It has normal hematopoietic function and is characterized by invasion to extramedullary tissue to form infiltrating lesions. The incidence in adults and children is 90% and 15%-20%, respectively. The incidence rate of acute leukemia in my country is on the rise every year, reaching 5.68 / 100,000. Currently, it is the 17th in the incidence of malignant tumors, and the 8th in the mortality rate among malignant tumors. [0003] At present, the treatment of AML is mainly based on chemotherapy. With the improvement of chemotherapy regimens, 50%-85% of patient...

Claims

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Application Information

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IPC IPC(8): A61K36/898A61P35/02
CPCA61K36/481A61K36/074A61K36/076A61K36/8945A61K36/898A61K36/896A61K36/536A61K36/748A61K36/539A61P35/02A61K2300/00A61K36/74
Inventor 陈涵徐瑞荣殷学伟
Owner 陈涵
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