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Method for extracting cannabidiol acid from cannabis sativa

A technology of cannabidiolic acid and cannabis, applied in the separation/purification of carboxylic acid compounds, non-central analgesics, digestive system, etc., can solve problems such as neglect of health-related abilities, achieve short time-consuming, high extraction rate, Simple operation effect

Pending Publication Date: 2022-03-22
哈尔滨市汉博生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Cannabidiolic acid was first isolated in 1955, but its potential health-related abilities were overlooked for years

Method used

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Experimental program
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Effect test

specific Embodiment approach 1

[0008] Specific Embodiment 1: This embodiment is a method for extracting cannabidiolic acid from cannabis, which is completed in the following steps: using fresh whole cannabis as raw material, using supercritical CO 2 As a solvent, ethanol solution with a mass fraction of 60% to 100% was used as an entrainer, and a supercritical CO 2 Extraction to obtain a yellow paste cannabis extract product, the mass fraction of cannabidiolic acid in the yellow paste cannabis extract product is 40% to 48%.

[0009] Cannabidiolic acid (CBDA) affects receptors that control anxiety and well-being, and CBDA acts as an antidepressant in doses 10 to 100 times lower than those required for cannabidiol (CBD). Therefore, the yellow paste cannabis extract obtained in this embodiment can replace CBD for the preparation of antidepressants.

[0010] CBDA inhibits breast cancer cell migration and causes downregulation of cyclooxygenase-2 (COX-2), and CBDA (i.p. at doses as low as 1 μg / kg) can induce po...

specific Embodiment approach 2

[0011] Specific embodiment two: the difference between this embodiment and specific embodiment one is: the whole fresh marijuana herb is pretreated, the specific process is as follows: the fresh marijuana whole herb is placed in a vacuum freeze dryer to dry until the moisture content is lower than 5% to obtain dried fresh whole cannabis herb, and then crush the dried fresh whole cannabis herb to 50-100 mesh to obtain cannabis powder. Others are the same as the first embodiment.

specific Embodiment approach 3

[0012] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that the supercritical CO 2 The extraction process is as follows: put the cannabis powder into the extraction kettle of the supercritical extraction machine, and use supercritical CO 2 As a solvent, an ethanol solution with a mass fraction of 60% to 100% is used as an entrainer, and the entrainer is added by continuous pump input; the relevant parameters of the extraction kettle are adjusted, the extraction pressure is controlled at 25MPa to 35MPa, and the temperature is controlled at 30 to 40°C. CO 2 The flow rate is controlled at 30L / h-40L / h, and the extraction time is 3h-5h; the relevant parameters of the separation tank are adjusted, the separation and analysis pressure is controlled at 8MPa-10MPa, and the separation temperature is controlled at 20-30°C to obtain a yellow paste product. The mass fraction of cannabidiolic acid in the paste product is 40%-48%. Others are the same as those ...

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Abstract

The invention relates to a method for extracting cannabidiol acid, in particular to a method for extracting cannabidiol acid from cannabis sativa. The invention provides a method for extracting cannabidiol acid from cannabis sativa. The method comprises the following steps: carrying out supercritical CO2 extraction by using a supercritical extraction instrument by taking fresh whole cannabis sativa as a raw material, supercritical CO2 as a solvent and an alcoholic solution as an entrainer. The method has the advantages of simplicity in operation, short time consumption, high extraction rate of cannabidiol acid and few impurities. The method is mainly used for extracting cannabidiol acid from cannabis sativa.

Description

technical field [0001] The invention relates to a method for extracting cannabidiolic acid. Background technique [0002] Cannabidiolic acid (CBDA), a 22-carbon terpene phenolic compound, is the major phytocannabinoid in cannabis; cannabidiolic acid is able to generate cannabidiol (CBD) through non-enzymatic decarboxylation during the extraction step, but In the fibrous cannabis plant, the concentration of cannabidiolic acid is much greater than that of cannabidiol. Cannabidiolic acid was first isolated in 1955, but its potential health-related abilities were overlooked for years. While the neutral derivative cannabidiol is of greater scientific interest, its biological / therapeutic properties are now well established. [0003] With recent research on cannabidiolic acid, it has been found that cannabidiolic acid is more effective than cannabidiol in reducing nausea. Cannabidiolic acid, like cannabidiol, has some of the most notable effects on the body through the activatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C51/47C07C65/19A61P25/24A61P35/00A61P29/00A61P1/08
CPCC07C51/47A61P25/24A61P35/00A61P29/00A61P1/08C07C2601/16C07C65/19Y02P20/54
Inventor 秦绪江孙秋君彭禹贾光远曲嵛
Owner 哈尔滨市汉博生物科技有限公司
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