Acid-responsive anticancer peptide and preparation method thereof
An anti-cancer peptide and responsive technology, which is applied in the field of artificially synthesized anti-cancer peptides and their acid-responsive nanoparticles, can solve the problems of low bioavailability, hindering anti-cancer peptides, and low selectivity, and achieve shielding of cytotoxicity, Improved stability, good targeting effects
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[0048] The present invention will be further described below in conjunction with the examples, but not as a limitation to the protection scope of the present invention.
[0049] Description of name and corresponding abbreviation or code:
[0050] The anticancer peptide of this example is called Peptide for short, and the code name in the synthesis route is C12-PButLG-CA;
[0051] The acid-responsive anticancer peptide nanoparticles of this embodiment are referred to as R Peptide, the code name in the synthetic route is: (PEO
[0052] -PPO-CDM) 2 -C12-PButLG-CA;
[0053] The non-acid-responsive anticancer peptide nanoparticles of this embodiment are referred to as NR Peptide, the code name in the synthetic route is: (PEO-
[0054] PPO-SA) 2 -C12-PButLG-CA;
[0055] 1. Peptides, R Peptide and NR Preparation of Peptides
[0056] 1.1 Synthesis and characterization of Peptide
[0057] The synthesis circuit diagram of Peptide is as follows figure 1 Shown, concrete synthe...
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