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Biomedical coating with excellent long-acting anticoagulation, antibacterial and anti-fouling performances and preparation method thereof

A biomedical and anticoagulant technology, applied in the field of biomedical coating and its preparation, can solve the problems of red blood cell hemolysis, limit application, increase the risk of thrombus, etc., and achieve simple operation, excellent bactericidal performance, and good blood compatibility sexual effect

Pending Publication Date: 2021-11-30
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

More importantly, due to the cationic nature of AMPs, they are also easy to adsorb and activate platelets, increase the risk of thrombosis, and may also induce red blood cell hemolysis, limiting their application in blood contactors or transplants

Method used

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  • Biomedical coating with excellent long-acting anticoagulation, antibacterial and anti-fouling performances and preparation method thereof
  • Biomedical coating with excellent long-acting anticoagulation, antibacterial and anti-fouling performances and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0033]A biomedical coating with excellent long-term anticoagulant and antibacterial and antifouling properties, the preparation method of which comprises the following steps in sequence:

[0034] (1) Clean the polyvinyl chloride catheter, and then perfuse it with benzophenone to fix it;

[0035] (2) Zwitterionic monomer 2-(methacryloyloxy)ethyl-2-(trimethylamino)ethyl phosphate (MPC) and monomer methacrylic acid (AAc) with double bond and carboxyl group ) into the polyvinyl chloride catheter, the ratio of the two monomers is 3:7, in-situ polymerization occurs under ultraviolet light irradiation, and the reaction time is 1 hour to obtain a hydrogel coating. After the reaction is completed, rinse with deionized water Remove residual unreacted 2-(methacryloyloxy)ethyl-2-(trimethylamino)ethyl phosphate (MPC) and methacrylic acid (AAc) on the surface for 2-3 days;

[0036] (3) Place the prepared hydrogel coating in an acidic environment (pH=4.0), and use 1-ethyl-(3-dimethylaminopr...

Embodiment 2

[0038] A biomedical coating with excellent long-term anticoagulant and antibacterial and antifouling properties and a preparation method thereof, the preparation method comprising the following steps:

[0039] (1) the polylactic acid material is cleaned, and then it is immersed in a benzophenone solution to fix the initiator;

[0040] (2) Zwitterionic monomer 2-(methacryloyloxy)ethyl-2-(trimethylamino)ethyl phosphate (MPC) and monomer methacrylic acid (AAc) with double bond and carboxyl group ) mixed solution is spread on the surface of polylactic acid material, the ratio of the two monomers is 3:7, in-situ polymerization occurs under ultraviolet light irradiation, the reaction time is 1.5 hours, and a hydrogel coating is obtained. After the reaction is completed, use Wash the surface with ionized water for 2-3 days to remove residual unreacted 2-(methacryloyloxy)ethyl-2-(trimethylamino)ethyl phosphate (MPC) and methacrylic acid (AAc);

[0041] (3) Place the prepared hydrogel...

Embodiment 3

[0043] A biomedical coating with excellent long-term anticoagulant and antibacterial and antifouling properties and a preparation method thereof, the preparation method comprising the following steps:

[0044] (1) the polyurethane material is cleaned, and then it is immersed in the azobisbutyronitrile solution to fix the initiator;

[0045] (2) Zwitterionic monomer [2-(methacryloyloxy) ethyl] dimethyl-(3-sulfonic acid propyl) ammonium hydroxide (SBMA) and monomer A with double bond and carboxyl group Spread acrylic acid (AAc) mixture on the surface of the polyurethane material, the ratio of the two monomers is 2:3, in-situ polymerization occurs under the irradiation of ultraviolet light, the reaction time is 2 hours, and the hydrogel coating is obtained, after the reaction is completed , Wash the surface with deionized water for 2-3 days to remove residual unreacted 2-(methacryloyloxy)ethyl]dimethyl-(3-sulfonic acid propyl)ammonium hydroxide (SBMA) and methyl Acrylic monomer ...

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Abstract

The invention provides a biomedical coating with excellent long-acting anticoagulation, antibacterial and anti-fouling performances and a preparation method thereof. The preparation method sequentially comprises the following steps: (1) cleaning a substrate material and fixing with an initiator; (2) under illumination, reacting a zwitterionic monomer with a monomer containing double bonds and a carboxyl for 1-3 h, and cleaning to obtain a medical coating; and (3) placing the medical coating obtained in step (2) in an acid environment, activating with a mixed solution, adding an antibacterial agent to react for 24 h, and sequentially cleaning and drying to obtain the biomedical coating with excellent long-acting anticoagulation, antibacterial and anti-fouling performances. The invention further comprises the biomedical coating prepared by the method. Based on good blood compatibility of a zwitter-ion-containing hydrogel, an adsorption function of a resistance protein and a bactericidal effect of an antibacterial agent, purposes of anticoagulation, antibiosis and anti-fouling on surfaces of blood contact instruments are achieved.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a biomedical coating with excellent long-term anticoagulant and antibacterial and antifouling properties and a preparation method thereof. Background technique [0002] Bacterial infection and blood clots are two major complications faced by blood-contact devices and materials. These problems can lead to implant failure and cause great pain to patients. Clinically, doctors often use combination therapy of thrombolytic drugs and antibiotics to solve this problem. However, the overuse of thrombolytic drugs and antibiotics will bring about the risk of massive bleeding and the emergence of drug-resistant bacteria. Therefore, surface functionalization can be used as an effective means to improve the antibacterial and antithrombotic properties of medical devices and implants. [0003] Sterilization and antifouling on material surfaces are two strategies to re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61L31/16A61L31/14A61L29/16A61L29/14A61L29/08C08F220/06C08F230/02C08F220/38C08F220/36
CPCA61L31/10A61L31/16A61L31/14A61L31/145A61L29/16A61L29/145A61L29/14A61L29/085C08F220/06A61L2300/252A61L2300/404A61L2300/602A61L2300/608A61L2300/406C08L33/02C08L43/02C08F230/02C08F220/387C08F220/365
Inventor 王云兵刘坤鹏罗日方杨立张凡军
Owner SICHUAN UNIV
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