Bundle shaping body for neutron capture therapy

A body shaping and beamline technology, applied in the fields of therapy, X-ray/γ-ray/particle irradiation, radiotherapy, etc., can solve the problem that the neutron flux cannot meet the effect of treating deep tumors, unfavorable processing and manufacturing, and accelerator end hazards. and other problems, to achieve the effect of improving epithermal neutron flux, convenient assembly and disassembly, and improving epithermal neutron flux

Pending Publication Date: 2022-03-29
INST OF HIGH ENERGY PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] (1) The retarder is a cone-shaped moderator formed in one piece. The moderator with this structure is not conducive to processing and manufacturing, and the neutron flux after moderation cannot meet the effect of treating deep tumors;
[0007] (2) The proton incident pipe is hollow cylindrical, and the hollow cylindrical channel tends to make more neutrons leak from this area, the utilization rate is not high, and it will also cause harm to the accelerator end

Method used

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  • Bundle shaping body for neutron capture therapy
  • Bundle shaping body for neutron capture therapy
  • Bundle shaping body for neutron capture therapy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Existing moderators used to moderate neutron beams are generally integrally formed moderators in the shape of cones. Moderators with this structure are not conducive to processing and manufacturing, and the neutron flux after moderation cannot meet the needs of treating deep tumors. Effect.

[0043] like figure 1As shown, the embodiment of the present invention includes a proton beam channel and a target body. Taking the direction of proton incidence as the positive direction, one end of the proton beam channel is connected to an accelerator, and the other end is connected to a target body; The extraction port is the rear end (that is, the epithermal neutron beam ejection end), so it can be seen that the target body is arranged at the end of the proton beam channel.

[0044] The beam shaper also includes a moderator, a reflector surrounding the moderator and the proton beam channel, a thermal neutron absorbing layer adjacent to the moderator, and a gamma beam adjacent ...

Embodiment 2

[0046] like figure 2 As shown, this embodiment is optimized on the basis of the foregoing embodiment 1. Specifically, the moderator in this embodiment is in the shape of a cylindrical stepped shaft, and the number of the stepped shaft segments is 2 to 10, preferably 3. ~8 paragraphs, preferably 5 paragraphs. Those skilled in the art can also understand in this way: with the proton incident place as the front end, the moderator can include a front end body, several middle end bodies and a rear end body in turn, and the front end body, middle end body and rear end body form a cylindrical ladder Shaft-shaped moderater body, the number of stepped shaft segments of the mid-end body is 0-8, preferably 0-6, and most preferably 3; Different diameters show a gradually decreasing distribution (those skilled in the art can easily understand that: with the direction of proton incident as the positive direction, the front end body, middle end body and rear end body are gradually decreasi...

Embodiment 3

[0051] like image 3 As shown, this embodiment is further optimized on the basis of the foregoing embodiment two. Specifically, there is a gap between the rear end body and the reflector in this embodiment (the stepped shaft section with the smallest outer diameter), and the designed gap cannot If the gap is too large, the fast neutron component of the outlet will be significantly increased. The gap should not be too small. If the gap is too small, the increase in the epithermal neutron component of the outlet will be limited. Therefore, the gap range is 1-20 mm, preferably 10mm, which can increase the leakage of epithermal neutrons at the outlet and increase the flux of epithermal neutrons, and (the stepped shaft section with the smallest outer diameter) the rear end body is adjacent to the thermal neutron absorbing layer, which has better economy.

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PUM

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Abstract

The invention discloses a beam shaping body for neutron capture therapy. The beam shaping device comprises a proton beam pore channel, a target body, a moderation body, a reflector surrounding the moderation body and the proton beam pore channel, a thermal neutron absorption layer adjacent to the moderation body, a gamma shielding layer adjacent to the thermal neutron absorption layer, and a collimation body arranged in the beam shaping body, a target body is arranged in the slowing-down body, and the target body is arranged at the tail end of the proton beam pore channel. The target body is arranged in the moderation body, and the depth of the target body penetrating into the moderation body is not smaller than 50 mm, so that the recoil neutrons can be sufficiently moderated, and the epithermal neutron flux of the leading-out opening is also improved.

Description

technical field [0001] The invention relates to the technical field of BNCT boron neutron capture therapy, in particular to a beam shaping body for deep tumor treatment. Background technique [0002] At present, photon or charged particle therapy is limited by the nature of the radiation. While killing tumor cells, it will also cause great damage to normal tissues in the area where the radiation passes. Moreover, for multilineage glioblastoma and melanoma Such highly radiation-resistant tumor cells are often ineffective by traditional radiation therapy. The neutron capture therapy, which has less radiation damage to normal tissues around the tumor and has a high relative biological effect in the target area, relies on the specific accumulation of boron-containing drugs in tumor cells, and cooperates with precisely regulated neutron beams to provide more radiation than traditional radiation. Better cancer treatment options. [0003] Boron Neutron Capture Therapy (BNCT) uses...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N5/10
CPCA61N5/1077A61N2005/109
Inventor 胡志良梁天骄傅世年陈俊阳童剑飞
Owner INST OF HIGH ENERGY PHYSICS CHINESE ACAD OF SCI
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