Pharmaceutical composition containing NAD (Nicotinamide Adenine Dinucleotide) and CD38 inhibitor and application thereof
A CD38 and composition technology, applied in the field of NAD-containing pharmaceutical compositions, can solve the problems of weakening the effect of NAD, limiting wide clinical applications, low NAD supplementation efficiency, etc., and achieving the effect of enhancing the effect and expanding the therapeutic range.
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Embodiment 1
[0031] Example 1 Adriamycin cardiotoxicity model construction method
[0032] Eight-week-old C57BL / 6 male mice were injected with 5 mg / kg of doxorubicin or normal saline into the tail vein, once a week for four consecutive weeks. Four weeks after the last administration, the mice were subjected to echocardiography to detect the heart function of the mice, and the myocardial tissue of the mice was taken to detect the NAD content.
Embodiment 2
[0034] Blank control group: the mice were intraperitoneally injected with the same volume of normal saline as that of the experimental group, the administration frequency was once a day, and the duration period was the same as that of the DIC model administration period. After the administration, echocardiography was performed on the mice to detect the heart function of the mice, and the myocardial tissue of the mice was taken to detect NAD + content.
[0035] NAD synthase Nampt agonist group: NAD synthase Nampt agonist P7C3 was dissolved in DMSO, and mice were injected intraperitoneally with 20 mg / kg NAD synthase Nampt agonist P7C3. same. After the administration, the myocardial tissue of the mice was taken to detect NAD + content.
[0036] NAD-depleting enzyme PARP inhibitor group: NAD-depleting enzyme PARP inhibitor Olaparib was dissolved in DMSO, and mice were injected intraperitoneally with 10 mg / kg NAD-consuming enzyme PARP inhibitor Olaparib. The frequency of Olapari...
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