Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Silica gel rhinoplasty material compounded with decalcified bone matrix

A technology of demineralized bone matrix and demineralized bone, applied in medical science, prosthesis, etc., can solve the problems of irregular shape, limited use and promotion, difficult to remove prosthesis, etc., to reduce the occurrence of complications and easy to degrade. , good biocompatibility

Active Publication Date: 2022-04-19
BEIJING XINKANGCHEN MEDICAL SCI & TECH DEV
View PDF5 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since liquid hydroxyapatite can diffuse along the interstitial space, and the shape is irregular after solidification, it is difficult to completely remove the prosthesis once rejection and other complications occur.
Therefore, the use of this method is limited

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Silica gel rhinoplasty material compounded with decalcified bone matrix
  • Silica gel rhinoplasty material compounded with decalcified bone matrix
  • Silica gel rhinoplasty material compounded with decalcified bone matrix

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Human decalcified bone meal (DBM, less than 150 microns) was selected to be compounded with silica gel in different mass ratios, and it was found that when the mass content of DBM reached 60%, it could not be bonded ( figure 1 ), adding Suo aloe vera gel and konjac gum (mass ratio 1:1), when the DBM mass content reaches 70%, it cannot be bonded, so the DBM accounts for less than 60% of the total mass in the subsequent composite material prepared later.

[0029] Composite materials with different DBM mass ratios of 0%, 10%, 20%, 25%, and 40% were prepared respectively:

[0030] Weigh 1.8g of silica gel, add 0.1g of calcium phosphate bone cement and stir evenly, raise the temperature to 70°C, add 0.05g of aloe vera gel and 0.05g of konjac gum, stir and mix evenly; add it into a 24-well plate and solidify at 70°C for 2 hours to obtain Composite 1 with 0% DBM content.

[0031] Weigh 1.6g of silica gel, add 0.2g of decalcified bone powder (less than 150 microns), stir well,...

Embodiment 2

[0040] The cytocompatibility of each group of composite materials in Example 1 was evaluated by using L929 cells. Take the sample of Example 1 and add it to the culture medium at a ratio of 0.2g / 1ml, and extract at 37°C for 24 hours to obtain an extract. Take normal cultured L929 cells and adjust the cell density to 2×10 4 / ml, inoculated into a 96-well culture plate, cultivated for 24 hours, discarded the original medium, and added the corresponding extract; after 72 hours, discarded the original medium, added 100ul of medium containing 10% CCK8 to each well, and after 30min The absorbance was detected at a wavelength of 450nm, and the growth state of the cells in the sample group and the relative proliferation rate of the cells were calculated (the control group was the medium without adding the extract).

[0041] The relative value-added rate results of the cells of composite materials 1-5 and comparative materials 1-3 are shown in Table 1:

[0042] Table 1

[0043]

Embodiment 3

[0044] Example 3 Safety of composite material implanted in vivo

[0045] Twelve male SD rats were selected. Before the test, the hairs on both sides of the rat’s spine were cut off. During the test, they were anesthetized by intravenous injection of pentobarbital sodium. Four implantation points were selected equidistantly at about 2.5 cm from the side, and each point was spaced 2.5 cm apart, and four materials with a mass content of DBM of 0%, 10%, 20%, and 40% were implanted into the subcutaneous tissue. The samples were collected at 6 months and 12 months respectively, and histological staining was used to observe the material degradation, inflammation, and adhesion to the surrounding tissues of the material. The results proved that the composite materials in each group were implanted safely, without degradation and inflammation.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention discloses a silica gel rhinoplasty material compounded with a decalcified bone matrix. Comprising silica gel, decalcified bone meal, a curing agent and a reinforced adhesive. The silica gel and the decalcified bone matrix are adopted to jointly construct the rhinoplasty prosthesis, an allogeneic tissue is simulated to reduce the probability of complications caused by long-term implantation of the silica gel, compared with the silica gel, the decalcified bone matrix has better biocompatibility and is easier to degrade, pores generated by degradation of the decalcified bone matrix are utilized, and the probability of complications caused by long-term implantation of the silica gel is reduced. Compared with other rhinoplasty prostheses, the silica gel prosthesis has the advantages that autologous tissue can grow into the silica gel, then the prosthesis is activated, complications are reduced, and compared with other rhinoplasty prostheses, the silica gel prosthesis is relatively easy to completely take out.

Description

technical field [0001] The invention belongs to the technical field of rhinoplasty prosthesis materials, and in particular relates to a silicone rhinoplasty material composited with decalcified bone matrix. Background technique [0002] According to the 2019 white paper on the medical beauty industry released by Gengmei APP, the scale of China's pure medical beauty market in 2019 reached 256 billion yuan, with an average growth rate of about 30% in the past five years, and the consumption of medical beauty treatments in China reached 25 million cases. It is estimated that the scale of China's medical aesthetics market will exceed one trillion yuan in 2025. Among them, rhinoplasty and other items are among the top ten sales on the Gengmei APP, and the rhinoplasty market has great potential for development. [0003] Commonly used prosthetic rhinoplasty materials are mainly solid silica gel, expanded body and autologous cartilage and biological rhinoplasty materials. And biol...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L27/36A61L27/12A61L27/02A61L27/20A61L27/50A61L27/58
CPCA61L27/3608A61L27/12A61L27/025A61L27/3637A61L27/20A61L27/50A61L27/58A61L2300/30C08L5/00
Inventor 刘永进胡先同韩丽伟赵子腾李金袁军林衷鸿宾李晋徐健龙
Owner BEIJING XINKANGCHEN MEDICAL SCI & TECH DEV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com