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Glucagon-loaded wearable device for treating hypoglycemia

A technology of glucagon and wearable devices, applied in the field of wearable devices

Pending Publication Date: 2022-04-22
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Based on the outstanding advantages of medical devices and the current research status, there is a lot of room for the development of wearable drug delivery devices, but so far there is no report on an intelligent wearable drug delivery system for the treatment of hypoglycemia

Method used

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  • Glucagon-loaded wearable device for treating hypoglycemia
  • Glucagon-loaded wearable device for treating hypoglycemia
  • Glucagon-loaded wearable device for treating hypoglycemia

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0071] The specific drug and the preparation of microneedle 410 are as follows: Figure 1-Figure 3 shown.

[0072] I. Preparation and Characterization of Glucagon Redox Cluster

[0073] Dissolve 100 mg of glucagon in 50 ml of PBS aqueous solution with a pH of 9, add 50 mg of NHS-S-S-NHS, stir magnetically at room temperature for 1 hour, separate and purify on a Sephadex column, and obtain glucagon redox Cluster ( figure 1 A). When the cluster encounters glutathione solution, the disulfide bond will be reduced and broken, a ring closure reaction will occur, and glucagon will be degraded and released ( figure 1 B).

[0074] The particle size of the prepared clusters was shown to be about 60nm ( figure 2 A), Zeta potential is -52.9mV ( figure 2 B), indicating that the cluster has good thermodynamic stability. Transmission electron microscope images show that the clusters are spherical in shape ( figure 2 C).

[0075] II. Preparation of Glucagon Redox Cluster Microneed...

experiment example 1

[0103] Experimental example 1. Appearance and morphology of glucagon redox cluster microneedle array

[0104] The prepared glucagon redox cluster microneedle array patches were respectively fixed with conductive tape, and the morphology of the microneedles was observed with a scanning electron microscope (SEM, JSM-6330F, Japan) at a voltage of 5 kV, and the obtained Figure 10 And measure the size of needle tip and needle height.

[0105] Figure 10 The morphology of one embodiment of the glucagon redox cluster microneedle array is shown, with sharp tips. The tip width is 15 μm, the tip length is 1800 μm, and the tip distance is 1500 μm.

experiment example 2

[0106] Experimental example 2. Mechanical strength of glucagon redox cluster microneedle array

[0107] Use double-sided tape to stick on the backing layer of the glucagon redox cluster microneedle array patch, and fix it on the metal stage of the compression-tensile tester (SGL-8000, Suzhou Shanggao Testing Equipment Co., Ltd.) , the tip of the microneedle faces the probe of the instrument, the probe presses down on the microneedle, and the force and displacement exerted by the instrument are recorded.

[0108] Such as Figure 11 As shown, the bearing capacity of the obtained microneedles is 0.19N, indicating that the microneedles have sufficient mechanical strength to pierce the stratum corneum of the skin.

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Abstract

The invention provides a glucagon-loaded wearable device for treating hypoglycemia, comprising: a housing, the housing comprising an upper cover, a bottom shell and watchbands arranged on two sides and used for fixing the wearable device on the surface of human skin; the control module, the lifting module and the drug delivery module are arranged in the shell, the drug delivery module comprises a microneedle array fixed to the bottom of the lifting module, the microneedle array comprises a plurality of microneedles, and each microneedle contains drugs; the control module at least comprises a detection probe and a signal processing module, the detection probe is fixed to the bottom of the shell and can be used for directly making contact with human skin and detecting human physiological indexes in real time, and the signal processing module is used for judging the relation between the human physiological indexes detected in real time and a normal physiological index threshold value; if yes, a control signal is sent out to control the lifting module to descend, and the lifting module drives the microneedle array to descend to release medicine. The invention also discloses a microneedle and a preparation method thereof.

Description

technical field [0001] The invention relates to a wearable device, in particular to a glucagon-loaded wearable device, which is used for real-time monitoring of glucose concentration in the body and controllable delivery of glucagon for timely drug delivery to realize rapid treatment of hypoglycemia. Background technique [0002] Hypoglycemia is a limiting factor for long-term maintenance of normoglycemia in diabetic patients. Minimizing the risk of hypoglycemia is an important issue in diabetes management. Hypoglycemia refers to adults with a fasting blood glucose concentration lower than 2.8mmol / L. Hypoglycemia can be diagnosed when the blood glucose level of diabetic patients is ≤3.9mmol / L. Hypoglycemia is a syndrome characterized by sympathetic nerve excitation and brain cell hypoxia, which is caused by a group of multiple etiologies with low venous plasma glucose (abbreviated blood sugar) concentration. Symptoms of hypoglycemia usually manifest as sweating, hunger, p...

Claims

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Application Information

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IPC IPC(8): A61B5/145A61M37/00A61K38/26A61K9/00A61K47/32A61K47/36A61K47/42A61K47/38A61K47/34A61P3/08
CPCA61B5/14503A61B5/14532A61B5/681A61M37/0015A61K38/26A61K9/0021A61K47/32A61K47/36A61K47/42A61K47/38A61K47/34A61P3/08A61M2037/0023A61M2037/0053
Inventor 郑超于翔谷卫张亦凯王声遥叶舒胡叶鹏
Owner ZHEJIANG UNIV
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