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Composite hydrogel and preparation method thereof

A technology of composite hydrogel and mixed solution, which can be used in pharmaceutical formulations, medical preparations with non-active ingredients, and aerosol delivery, etc., and can solve problems such as unsatisfactory overall healing effect.

Active Publication Date: 2022-04-22
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, most of these dressing materials can only play a role for a certain reason of unhealed wounds, and the overall healing effect is not ideal.

Method used

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  • Composite hydrogel and preparation method thereof
  • Composite hydrogel and preparation method thereof
  • Composite hydrogel and preparation method thereof

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preparation example Construction

[0085] The present invention also provides a method for preparing the composite hydrogel described above, comprising the following steps:

[0086] The loaded MOFs are dissolved in the solvent medium, and the obtained mixed solution is mixed with aldylated hyaluronic acid (HA-CHO) having the structure shown in formula (I) and hyaluronic acid-hexadiene having the structure shown in formula (II) Acid dihydrazide derivatives (HA-ADH) were mixed to obtain a composite hydrogel.

[0087] In some embodiments of the present invention, the preparation method of the composite hydrogel comprises the following steps:

[0088] A) dissolving the loaded MOFs in a solvent medium to obtain a loaded MOFs solution;

[0089] B) mixing the partly loaded MOFs solution with the aldylated hyaluronic acid (HA-CHO) having the structure shown in formula (I), to obtain the HA-CHO mixed solution;

[0090] Mix the remaining loaded MOFs solution with the hyaluronic acid-adipate dihydrazide derivative (HA-A...

Embodiment 1

[0129] Take 2.0g (0.005mol) of sodium hyaluronate (10% oxidation degree) with a number average molecular weight of 40000 and dissolve it in 200mL of deionized water to obtain a sodium hyaluronate solution; another 1.1276g (0.005mol) of sodium periodate Dissolve in 20 mL of deionized water to obtain a sodium periodate solution; then add the sodium periodate solution dropwise into the sodium hyaluronate solution, and react at 20° C. for 5 hours under the condition of avoiding light. Add 6mL of ethylene glycol and continue to stir in the dark for 30min to terminate the oxidation reaction, add the reacted reaction solution into a dialysis bag with a molecular weight cut-off of 3500, dialyze and purify in deionized water, and further lyophilize to obtain Aldylated hyaluronic acid (HA-CHO) of the structure shown, wherein, m=10, n=100.

[0130] The obtained HA-CHO was analyzed by proton nuclear magnetic spectrum data, and the results were as follows: figure 1 shown. figure 1 It is ...

Embodiment 2

[0132] Take 0.6g (0.0015mol) of sodium hyaluronate (40% oxidation degree) with a number average molecular weight of 24000 and dissolve it in 60mL of deionized water to obtain a sodium hyaluronate solution; another 0.3388g (0.0015mol) of sodium periodate Dissolve in 6 mL of deionized water to obtain a sodium periodate solution; then add the sodium periodate solution dropwise into the sodium hyaluronate solution, and react at 25° C. for 5 hours under the condition of avoiding light. Add 0.6mL of ethylene glycol and continue to stir in the dark for 30min to terminate the oxidation reaction. The reaction solution after the reaction is added into a dialysis bag with a molecular weight cut-off of 3500, purified by dialysis in deionized water, and further freeze-dried to obtain ) the formylated hyaluronic acid (HA-CHO) of the structure shown, wherein, m=24, n=60.

[0133] The obtained HA-CHO was analyzed by proton nuclear magnetic spectrum data, and the results were as follows: fig...

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Abstract

The invention relates to the technical field of polymer drugs, in particular to composite hydrogel and a preparation method thereof. The invention provides composite hydrogel. The composite hydrogel is prepared from 28.15 wt%-97.85 wt% of a substance a and 28.15 wt%-97.85 wt% of a substance b, 0.02 wt% to 70.5 wt% of loaded MOFs (metal organic frameworks); 1 wt%-4.75 wt% of a solvent medium; the sum of the use amounts of the components is 100%. The substance a comprises formylated hyaluronic acid with a structure as shown in a formula (I) and a hyaluronic acid-adipic acid dihydrazide derivative with a structure as shown in a formula (II); the loaded MOFs comprise MOFs with a structure as shown in a formula (III) and a load; the load comprises a drug and / or a bioactive component. The composite hydrogel provided by the invention can greatly reduce the burst release behavior of drugs in the hydrogel, and the preparation method has the advantages of convenience in operation, simple process, mild reaction, no harmful by-product and the like.

Description

technical field [0001] The invention relates to the technical field of polymer medicine, in particular to a composite hydrogel and a preparation method thereof. Background technique [0002] Diabetes is a common disease in the world. In 2015, the number of people with diabetes in the world was 415 million. In 2040, this figure will reach 642 million. As the number of diabetic patients worldwide increases, so does the need for care and treatment of chronic wounds closely associated with it. [0003] Currently, there is a lot of research on wound dressings, but there are very few dressings for diabetic chronic wounds. Diabetics are in a state of high blood sugar for a long time, resulting in certain damage to the microvascular, nervous system and immune system. Therefore, once a wound appears, it is easy to form chronic inflammation, which cannot be cured for a long time. Chronic inflammation is mainly manifested in the presence of a large number of inflammatory cells, infl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/24A61K47/36C08B37/08C08G83/00
CPCA61K9/06A61K47/36A61K47/24C08B37/0072C08G83/008
Inventor 李杲王蓉蓉周宇豪荣岩贺超良陈学思
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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