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Polymyxin antibiotic synergist and anti-gram-negative bacteria pharmaceutical composition

A technology of Gram-negative bacteria and polymyxin, applied in the field of biomedicine, can solve the problems of long development cycle of new antibiotic drugs, low success rate, difficulty in meeting demand, etc., to restore antibacterial activity in vivo and in vitro, inhibit The effect of drug resistance

Pending Publication Date: 2022-04-22
科辉智药生物科技(无锡)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Difficult to meet demand due to long development cycle and low success rate of new antibiotic drugs

Method used

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  • Polymyxin antibiotic synergist and anti-gram-negative bacteria pharmaceutical composition
  • Polymyxin antibiotic synergist and anti-gram-negative bacteria pharmaceutical composition
  • Polymyxin antibiotic synergist and anti-gram-negative bacteria pharmaceutical composition

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Experimental program
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Effect test

preparation example Construction

[0034] The preparation method of LB broth medium is as follows: Weigh 8 g of tryptone powder, 8 g of NaCl, and 4 g of yeast, dissolve them in 800 mL of distilled water, autoclave at 121° C. for 15 minutes, and store at 4° C.

[0035] The preparation method of PBS buffer solution is: weigh NaCl 8g, KCl 0.2g, NaCl 2 HPO 4 12H 2 O 3.58g, KH 2 PO 4Dissolve 0.24g in 1000mL of distilled water, autoclave at 121°C for 15 minutes, and store at room temperature.

Embodiment 1

[0037] An anti-gram-negative bacteria pharmaceutical composition comprises dronedarone and polymyxin B. The chemical name of dronedarone is N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-1-benzofuran-5-yl]methanol Sulfonamide, the PubChem CID number is 208898, the specific structural formula is as follows:

[0038]

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PUM

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Abstract

The invention discloses a polymyxin antibiotic synergist and an anti-gram-negative bacteria pharmaceutical composition, dronedarone or a pharmaceutically acceptable salt thereof is taken as the polymyxin antibiotic synergist and is combined with polymyxin antibiotics, so that the activity of the polymyxin antibiotics in resisting drug-resistant bacteria can be effectively improved, and the anti-gram-negative bacteria pharmaceutical composition has the advantages that the anti-gram-negative bacteria pharmaceutical composition is prepared; the drug resistance of polymyxin antibiotics is inhibited; meanwhile, the dronedarone can significantly reduce the dosage of polymyxin antibiotics, and is beneficial to reducing side effects caused by drug use.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a polymyxin antibiotic synergist and an anti-gram-negative bacteria pharmaceutical composition. Background technique [0002] According to the statistics of the World Health Organization, about 700,000 people die from bacterial infections every year in the world. In the treatment of various bacterial infections or pathogenic microbial infections, antibiotics are the main drug used, but with the use of antibiotics, bacteria can strengthen their drug resistance through various ways, including secreting a variety of antibiotic hydrolytic enzymes (super Broad-spectrum β-lactamase, carbapenemase, etc.), gene mutations of drug action targets, loss or translocation of membrane porins, active efflux pump system, etc., the above pathways have caused bacterial antibiotic resistance, And this phenomenon is spreading globally, posing a serious threat to the global medical and health sys...

Claims

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Application Information

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IPC IPC(8): A61K31/343A61K38/12A61P31/04
CPCA61K31/343A61K38/12A61P31/04A61K2300/00Y02A50/30
Inventor 黄维胡春霞崔瑞勤余慧娟
Owner 科辉智药生物科技(无锡)有限公司
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