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Medicine for relieving anxiety disorder and depression

A technology for anxiety and depression, applied in the field of traditional Chinese medicine extracts

Pending Publication Date: 2022-04-26
重庆市九龙坡区精神卫生中心(重庆市九龙坡区石坪桥医院)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on its effect on relieving anxiety and depression

Method used

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  • Medicine for relieving anxiety disorder and depression
  • Medicine for relieving anxiety disorder and depression
  • Medicine for relieving anxiety disorder and depression

Examples

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Effect test

Embodiment 1

[0011] A preparation method for medicament for relieving anxiety and depression. Take 20kg of dried whole herb of Fujishipine, pulverize it, add ethanol for hot reflux extraction, filter and concentrate to obtain extract.

[0012] Further, the above-mentioned extract was extracted by adding tartaric acid aqueous solution and ethyl acetate, the pH value of the aqueous phase was adjusted, and then extracted with chloroform, and the extract was concentrated to obtain the extract.

[0013] The details are as follows: take 20kg of dried whole herb of Fujishipine, crush it, and reflux extract it with 120L 70-90% ethanol for 3 times, each time for 2 hours, at a temperature of 70-85°C, and concentrate the extract into 1.8kg of full-fluid extract. Add 3% tartaric acid aqueous solution and ethyl acetate to the liquid extract to suspend to 20L, and then use saturated Na 2 CO 3 After adjusting the pH to 10, it was extracted with chloroform to obtain an ethyl acetate extract (238 g) and a...

Embodiment 2

[0016] A preparation method for medicament for relieving anxiety and depression. Take 20kg of dried whole herb of Fujishisatsu, pulverize it, add methanol to heat reflux extraction, filter and concentrate to obtain extract.

[0017] Further, the above-mentioned extract was extracted by adding tartaric acid aqueous solution and ethyl acetate, the pH value of the aqueous phase was adjusted, and then extracted with chloroform, and the extract was concentrated to obtain the extract.

[0018] The details are as follows: take 20kg of dried whole herb of Fujishipine, reflux extraction with 120L of 70-85% methanol for 3 times, each time for 2h, at a temperature of 70-85°C, and concentrate the extract into 2kg of full-flow extract. Add 3% tartaric acid aqueous solution and ethyl acetate to the liquid extract to suspend to 25L, and then use saturated Na 2 CO 3 After adjusting the pH to 10, it was extracted with chloroform to obtain an ethyl acetate extract (256 g) and a chloroform extr...

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Abstract

The invention discloses an application of a lycopodium clavatum extract in preparation of drugs for relieving anxiety disorder and depression and a preparation method of the lycopodium clavatum extract, the lycopodium clavatum extract comprises an ethanol extract and / or a methanol extract of lycopodium clavatum, and mouse tail suspension and forced swimming experiments prove that the traditional Chinese medicine extract can effectively relieve anxiety disorder and depression.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine extracts, and relates to a traditional Chinese medicine extract for alleviating anxiety and depression. Background technique [0002] Depression and anxiety, as common mental disorders, have the characteristics of high prevalence, high disability rate and high recurrence rate, which seriously affect human health. Currently, the commonly used antidepressants in clinical practice are mainly western medicines. , such as imipramine, flupentixol melitracen tablets, and new antidepressant and anxiety drug paroxetine hydrochloride, etc., but there are many contraindications, high addiction, obvious side effects, easy recurrence after drug withdrawal, and low effective rate , and poor patient compliance. [0003] Depression and anxiety belong to the category of "depression syndrome" in traditional Chinese medicine. They are mostly caused by emotional disturbance, leading to stagnatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4748A61K36/11A61P25/22A61P25/24
CPCA61K31/4748A61K36/11A61P25/22A61P25/24A61K2236/333A61K2236/39A61K2236/51
Inventor 庞金宇
Owner 重庆市九龙坡区精神卫生中心(重庆市九龙坡区石坪桥医院)
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