Nintedanib skin disease compositions and methods for treating neovascularization
A technology for skin diseases and new blood vessels, applied in the field of medicine, can solve skin diseases without nintedanib, can not solve the problem of new blood vessels, skin abnormalities and other problems
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Embodiment 1
[0017] Embodiment 1: The purpose of the present invention is to provide a new application of nintedanib, and further tests will be carried out on the treatment of animal experimental models.
[0018] Test materials: 100 SD rats with skin disease of neovascularization;
[0019] Reagent: nintedanib purity 99.97%);
[0020] Nintedanib is added with auxiliary materials to make ointment for external use, such as 1 part of Nintedanib, 10 parts of white petrolatum, and 10 parts of propylene glycol. After mixing, Nintedanib cream for external use is obtained. There is no obvious acute toxic reaction, no irritation, and no local and systemic allergic reactions when applied to the skin of rats.
Embodiment 2
[0021] Embodiment 2: Test material: 100 SD rats with skin disease of neovascularization;
[0022] Reagent: nintedanib purity 99.97%);
[0023] Nintedanib is added with auxiliary materials to make ointment for external use, such as 10 parts of Nintedanib, 10 parts of white petrolatum, and 10 parts of propylene glycol. After mixing, Nintedanib cream for external use is obtained. There is no obvious acute toxic reaction, no irritation, and no local and systemic allergic reactions when applied to the skin of rats.
Embodiment 3
[0024] Embodiment 3: Test material: 100 SD rats with skin disease of neovascularization;
[0025] Reagent: nintedanib purity 99.97%);
[0026] Nintedanib is made into external ointment by adding auxiliary materials, such as 30 parts of Nintedanib, 10 parts of white petrolatum, and 10 parts of propylene glycol, and after mixing, Nintedanib cream for external use is obtained. There is no obvious acute toxic reaction, no irritation, and no local and systemic allergic reactions when applied to the skin of rats.
[0027] Treatment days Embodiment 1 (therapeutic rate %) Embodiment 2 (therapeutic rate %) Embodiment 2 (therapeutic rate %) 10 days 10 20 30 20 days 20 40 70 30 days 40 60 90
[0028] According to the above results, it is shown that nintedanib has a good therapeutic effect on the treatment of skin diseases caused by neovascularization.
[0029] Therefore, the nintedanib method for treating skin diseases caused by neovasculariza...
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