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Hyaluronic acid-polyethylene glycol-layered silicon dioxide composite hydrogel and application thereof

A technology of composite hydrogel and hyaluronic acid, applied in application, surgical adhesive, medical science and other directions, can solve the problems of easy degradation of hyaluronic acid hydrogel, increase in gel viscosity, etc. Simple to use and stable effect

Pending Publication Date: 2022-04-26
SHANGHAI RUINING BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention aims at the problem that the hyaluronic acid hydrogel is easy to degrade in the prior art, adds layered silica to the hyaluronic acid hydrogel to improve the stability of the gel, and uses polyethylene glycol to solve the problem of layered silica The problem of a large increase in gel viscosity after addition, resulting in an injectable, stable sodium hyaluronate complex hydrogel

Method used

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  • Hyaluronic acid-polyethylene glycol-layered silicon dioxide composite hydrogel and application thereof
  • Hyaluronic acid-polyethylene glycol-layered silicon dioxide composite hydrogel and application thereof
  • Hyaluronic acid-polyethylene glycol-layered silicon dioxide composite hydrogel and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The preparation of embodiment 1 hyaluronic acid composite hydrogel

[0024] Taking sodium hyaluronate with a molecular weight of 1.4 million as an example, the effect of adding layered silica and polyethylene glycol on the viscosity of hydrogel was investigated.

[0025] HA hydrogel sample No. 1: Add 0.25 g of HA with a molecular weight of 1.4 million to 100 mL of deionized water, and stir evenly to obtain HA hydrogel sample No. 1.

[0026] HA hydrogel sample No. 2: Add 0.25 g of HA with a molecular weight of 1.4 million to 100 mL of deionized water, stir evenly, continue to add 2 g of layered silica Laponite, and stir evenly to obtain HA hydrogel sample No. 2.

[0027] HA hydrogel sample No. 3: Add 0.25 g of HA with a molecular weight of 1.4 million to 100 mL of deionized water, and stir evenly. Continue to add 2g of layered silica Laponite, and stir evenly. Further add 0.235g CaCl 2 2H 2 O, 0.215g NaCl and 2g molecular weight are the polyethylene glycol mixed powd...

Embodiment 2

[0041] Taking HA with a molecular weight of 1.4 million as an example, the effect of adding polyethylene glycol with different molecular weights on the viscosity of hydrogel was investigated.

[0042] HA hydrogel sample No. 10: Add 0.5 g of HA with a molecular weight of 1.4 million to 100 mL of deionized water, and stir evenly. Continue to add 2g of layered silica Laponite, and stir evenly. Further add 0.235g CaCl 2 2H 2 O, 0.215g NaCl and 3g molecular weight are the polyethylene glycol mixed powder of 600Da, stir evenly, obtain HA hydrogel sample No. 10.

[0043] HA hydrogel sample No. 11: Add 0.5 g of HA with a molecular weight of 1.4 million to 100 mL of deionized water, and stir evenly. Continue to add 2g of layered silica Laponite, and stir evenly. Further add 0.235g CaCl2·2H2O, 0.215g NaCl and 3g polyethylene glycol mixed powder with a molecular weight of 4000000Da, stir evenly, and obtain HA hydrogel sample No. 11.

[0044] The impact of polyethylene glycol with di...

Embodiment 3

[0047] Example 3 The ability of polyethylene glycol to adjust the viscosity of hyaluronic acid hydrogels with different molecular weights HA hydrogel No. 12 sample: 0.5 g of HA with a molecular weight of 400,000 Da was added to 100 mL of deionized water, and mechanically stirred to obtain HA hydrogel sample No. 12.

[0048] HA hydrogel sample No. 13: Add 0.5 g of HA with a molecular weight of 400,000 Da to 100 mL of deionized water, stir evenly, and continue to add 2 g of layered silica Laponite and stir evenly to obtain HA hydrogel sample No. 13.

[0049] HA hydrogel sample No. 14: Add 0.5 g of HA with a molecular weight of 400,000 Da to 100 mL of deionized water, and stir evenly. Continue to add 2g of layered silica Laponite, and stir evenly. Further add 0.235g CaCl 2 2H 2 O, 0.215g NaCl and 2g molecular weight are the polyethylene glycol mixed powder of 6000Da, stir evenly, obtain HA hydrogel sample No. 14.

[0050] The results are shown in Table 3. Combining the result...

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Abstract

The invention discloses hyaluronic acid-polyethylene glycol-layered silicon dioxide composite hydrogel which comprises hyaluronic acid, layered silicon dioxide, polyethylene glycol, inorganic salt and water. The defects that hyaluronic acid is rapidly absorbed in a human body and stays in tissues for a short time and the like in the prior art are overcome, the stability of the hyaluronic acid hydrogel is improved by utilizing the layered silicon dioxide, a relatively long filling effect can be maintained, and the problem that the viscosity of a gel system is increased is obviously reduced by utilizing the polyethylene glycol. The composite hydrogel can be used as a novel tissue filling agent, a tissue anti-adhesion agent, a tissue engineering scaffold, a sealing agent or an embolization agent for clinical diagnosis or treatment.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to an injectable hyaluronic acid-polyethylene glycol-layered silicon dioxide composite hydrogel and its application. [0002] technical background [0003] Hyaluronic acid (Hyaluronic acid referred to as HA), also known as hyaluronic acid, glass uronic acid, glass sugar carbonic acid, is an acidic acid composed of disaccharides (D-glucuronic acid and N-acetylglucosamine) basic structure. Mucopolysaccharides. Hyaluronic acid widely exists in connective tissue, epithelial tissue and nerve tissue. With its unique molecular structure and physical and chemical properties, it shows a variety of important physiological functions in the body, such as lubricating joints, regulating the permeability of blood vessel walls, regulating Diffusion and operation of protein, water and electrolyte, promote wound healing, etc. Hyaluronic acid is widely used in various ophthalmic operations in medi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L71/02C08L5/08C08K7/00C08K3/36A61L24/00A61L24/02A61L24/04A61L24/08A61L27/02A61L27/18A61L27/20A61L27/52A61L31/02A61L31/04A61L31/06A61L31/14
CPCC08J3/075A61L27/20A61L27/18A61L27/025A61L27/52A61L31/042A61L31/06A61L31/028A61L31/145A61L24/08A61L24/046A61L24/02A61L24/0031C08J2371/02C08J2405/08C08K7/00C08K3/36C08L5/08C08L71/02
Inventor 胡怡晨潘震
Owner SHANGHAI RUINING BIOTECH CO LTD